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Quantitative X-Ray Computed Tomography (CT) in Dementia of the Alzheimer Type (DAT)

Published online by Cambridge University Press:  18 September 2015

J.S. Luxenberg ,
R.P. Friedland  and
S.I. Rapoport
J.S. Luxenberg*
Affiliation:
Section Brain Aging and Dementia, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD USA
R.P. Friedland
Affiliation:
Section Brain Aging and Dementia, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD USA
S.I. Rapoport
Affiliation:
Section Brain Aging and Dementia, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD USA
*
Laboratory of Neurosciences, Section on Brain Aging and Dementia, National Institute on Aging, Building 10, Room 12S235B, National Institutes of Health, Bethesda, MD 20892 USA
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Abstract:

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Dementia of the Alzheimer type (DAT) has proven to be difficult to diagnose using computerized X-ray tomography (CT). To improve the identification of DAT with CT, several different quantitative approaches have been tried. Brain parenchymal density measurements and a variety of linear indices of ventricular size have failed to reliably separate DAT patients from age matched controls. Measures of ventricular volume improve discrimination, but overlap with controls persists. The inadequacy of a single CT study to diagnose DAT is clearly related to the overlap of brain atrophy in DAT and healthy aging, a finding which has also been noted in post-mortem studies. Estimating the rate of ventricular enlargement from quantitative measurements of ventricular size on successive CT scans may allow the physician to take advantage of the progressive nature of DAT, improving separation of DAT patients from healthy controls.

Type
Imaging of Demented Subjects
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 570 - 572
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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