Skip to main content Accessibility help
×
Home
Hostname: page-component-5c569c448b-gctlb Total loading time: 0.576 Render date: 2022-07-03T09:24:22.716Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true } hasContentIssue true

P.093 Hemoglobin values, fluctuations from baseline, and transfusion as predictors of outcome following aneurysmal subarachnoid hemorrhage

Published online by Cambridge University Press:  27 June 2018

Rights & Permissions[Opens in a new window]

Abstract

HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Background: Anemia following aneurysmal subarachnoid hemorrhage (aSAH) has been associated with poor outcome, but complications from transfusion have limited aggressive management of anemic patients. This study examined the relationship between hemoglobin levels, transfusion and outcome following aSAH. Methods: We performed a post-hoc analysis of the CONSCIOUS-1 trial. Poor outcome was defined as a 3-month modified Rankin Scale > 2. Minimum hemoglobin levels were evaluated as predictors of outcome using logistic regression analysis, ROC curve analysis, and LOWESS curves. Propensity score matching was used to assess the effect of transfusion on poor outcome in patients with minimum hemoglobin levels between 70-90 and 80-100 g/L. Results: Lower minimum hemoglobin levels were associated with poor outcome on both univariate (p<0.001) and multivariate (p=0.012) analysis. Area under the ROC curve for minimum hemoglobin was 0.673. Youden index analysis found a minimum hemoglobin threshold of 91.5 g/L maximally predictive for good functional outcome. Propensity score matching showed a trend towards poor outcome in transfused patients with minimum hemoglobin levels between 70-90 and 80-100 g/L (p=0.052 and 0.09). Conclusions: This work suggests that decreasing hemoglobin is an independent predictor of poor outcome following aSAH. However, there was a trend towards poor outcome in transfused patients. The optimal transfusion threshold should be evaluated by prospective trials.

Type
POSTER PRESENTATIONS
Copyright
© The Canadian Journal of Neurological Sciences Inc. 2018 
You have Access

Save article to Kindle

To save this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

P.093 Hemoglobin values, fluctuations from baseline, and transfusion as predictors of outcome following aneurysmal subarachnoid hemorrhage
Available formats
×

Save article to Dropbox

To save this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about saving content to Dropbox.

P.093 Hemoglobin values, fluctuations from baseline, and transfusion as predictors of outcome following aneurysmal subarachnoid hemorrhage
Available formats
×

Save article to Google Drive

To save this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about saving content to Google Drive.

P.093 Hemoglobin values, fluctuations from baseline, and transfusion as predictors of outcome following aneurysmal subarachnoid hemorrhage
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *