Hostname: page-component-7c8c6479df-5xszh Total loading time: 0 Render date: 2024-03-19T07:14:16.275Z Has data issue: false hasContentIssue false

Noninvasive assessment of ischemic penumbra by using MR-SWI during the acute phase of cerebral infarction: a comparison to PWI

Published online by Cambridge University Press:  03 June 2015

S Luo
Affiliation:
(Changchun)
X Wu
Affiliation:
(Changchun)
F Deng
Affiliation:
(Changchun)
Y Zhang
Affiliation:
(Changchun)
J Miao
Affiliation:
(Changchun)
Y Chen
Affiliation:
(Changchun)
L Wang
Affiliation:
(Changchun)
J Feng
Affiliation:
(Changchun)
H Zhang
Affiliation:
(Changchun)
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Background: Assessment of ischemic penumbra during the acute stage of cerebral infarction is crucial for a decision to initiate thrombolytic therapy and for predicting stroke evolution. Although controversial as a perfect equivalence to penumbra, perfusion weighted imaging (PWI)-diffusion weighted imaging (DWI) mismatch may predict the response to thrombolysis. Due to the reliance on contrast agents in PWI, noninvasive alternatives remain an unmet need. Methods: We herein investigate the potentials of SWI as an alternative to PWI in defining ischemic penumbra and in predicting stroke outcome. A multimodal magnetic resonance imaging work-up which includes conventional magnetic resonance imaging sequences (T1WI, T2WI and FLAIR), DWI, PWI and SWI was performed. The Alberta Stroke Programme Early CT Score (ASPECTS) was used to evaluate the changes in DWI, SWI and PWI. Results: The mismatch of SWI-DWI was comparable with that of PWI-DWI (p>0.05). Furthermore, the grade of prominent vein and the cerebral blood volume in the ipsilateral brain tissue were positively correlated. Conclusions: SWI can be used as a noninvasive alternative to identify occlusive arteries and to evaluate the ischemic penumbra. The susceptibility vein sign may represent thrombosis in arteries whereby being helpful to identify responsible blood vessels in ischemic stroke.

Type
Poster Presentations
Copyright
Copyright © The Canadian Journal of Neurological Sciences Inc. 2015