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Neuronal Loss in a Lower Motor Neuron Disease Induced by a Murine Retrovirus

Published online by Cambridge University Press:  18 September 2015

Paul Jolicoeur
Paul Jolicoeur*
Affiliation:
Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Montreal
*
Laboratory Molecular Biology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
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Abstract:

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An animal model of neuronal loss induced by a murine retrovirus is described. The neurological disease is manifested by a lower limb paralysis and is characterized as a spongiform myeloencephalopathy. The primary determinant of neurovirulence has been mapped within the viral env sequences and a secondary determinant is present within the LTR region. A model of pathogenesis, suggesting that the disease is receptor-mediated, is proposed.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S3 , August 1991 , pp. 411 - 413
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

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