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Multiple Sclerosis and Diabetes Mellitus: Further Evidence of a Relationship

Published online by Cambridge University Press:  18 September 2015

Sharon A. Warren  and
K.G. Warren
Sharon A. Warren*
Affiliation:
Department of Health Services, Administration and Community Medicine and the MS Research Clinic, Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta
K.G. Warren*
Affiliation:
Department of Health Services, Administration and Community Medicine and the MS Research Clinic, Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta
*
Department of Health Services, Administration and Community Medicine, 13-103 Clinical Sciences Bldg., The University of Alberta, Edmonton, Alberta T6G 2G3
Department of Health Services, Administration and Community Medicine, 13-103 Clinical Sciences Bldg., The University of Alberta, Edmonton, Alberta T6G 2G3
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Summary:

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One hundred multiple sclerosis (MS) patients were compared to healthy controls to determine the prevalence of diabetes mellitus in their families. Significantly, more MS patients than controls were diabetic or reported at least one first degree relative (parent, sibling, child) with diabetes. The relationship between MS and diabetes persisted when second degree relatives (grandparents, aunts and uncles) were taken into consideration.

A greater percentage of MS patients with another MS relative were diabetic or reported a first degree relative with diabetes mellitus than MS patients without an MS relative. However the difference was not statistically significant. Nor was there a significant difference when percentages reporting either a first or a second degree relative with diabetes were compared.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 4 , November 1982 , pp. 415 - 419
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

Acheson, E.D. (1972) The epidemiology of multiple sclerosis. In Multiple Sclerosis: A Reappraisal, Mcalpine, D., Lumsden, C.E. and Acheson, E.D. (Eds.), Churchill Livingston, London.Google Scholar
Alter, M. (1977) Clues to the cause based upon the epidemiology of MS. In MS: A Critical Conspectus, Field, E.J. (Ed.) University Park Press, Baltimore.Google Scholar
Craelius, W., Newby, N. and Thomas, F.C. (1978) Central myelination in vitro: effect of reduced calcium and magnesium. Neurological Absts.Google Scholar
Dick, G. (1976) The etiology of multiple sclerosis. Proc. Roy. Soc. Med. 69: 611–15.CrossRefGoogle ScholarPubMed
Ebers, G.MS Clinic, University of Western Ontario, London, personal communication, 1980.Google Scholar
Ehrentheil, O., Schulman, M. and Alexander, L. (1952) Role of food allergy in multiple sclerosis. Neurology, 2: 412–27.CrossRefGoogle ScholarPubMed
Forbath, N. (1981) Diabetes and its complications. Med. Clin. N.A., 12: 1300–7.Google Scholar
Frovig, A., Presthus, J. and Sponheim, N. (1967) The significance of allergy in the etiology and pathogenesis of multiple sclerosis. Acta Psych. (Scand.), 43: 215–25.Google ScholarPubMed
Goldberg, P. (1974) Multiple sclerosis: vitamin D and calcium as environmental determinants of prevention. Parts I and II. Inter. J. Envir. Stud., 6: 19–27, 121–29.CrossRefGoogle Scholar
Hoskins, B., Feibelman, R., Loury, A. et al. (1979) Effectiveness of insulin therapy on altered renal calcium transport in diabetic rats. Diabetes, 28: 1088–94.CrossRefGoogle Scholar
Mcalpine, D. and Compston, M.D. (1952) Some aspects of the history of disseminated sclerosis. Quar. Jour. Med., 21: 135–67.Google ScholarPubMed
Raskin, P., Stevenson, M., Barilla, D. et al. (1978) The hypercalcuria of diabetes mellitus: its amelioration with insulin. Presented at the 38th Annual Meeting of the American Diabetes Association, Boston.CrossRefGoogle Scholar
Roberts, H. (1966) On the etiology, rational treatment and prevention of multiple sclerosis. Southern Med. J., 59: 940–50.CrossRefGoogle ScholarPubMed
Sherwin, R. and Felig, P. (1978) Pathophysiology of diabetes mellitus. In Symposium on Diabetes Mellitus. Med. Clin. N.A., Podolsky, S. (Ed.), W.B. Saunders, Co., Philadelphia.Google Scholar
Sibley, W.A., Bamford, D. and Laquna, F. (1978) Anamnestic studies in multiple sclerosis: a relationship between familial multiple sclerosis and neoplasia. Neurology, 28: 125–29.CrossRefGoogle ScholarPubMed
Sorensen, K., Christensen, S., Dupont, E., Hansen, A., Pederson, E. and Orskov, H. (1980) Low somatostatin content in cerebrospinal fluid in MS: An indicator of disease activity? Acta Neuro. Scand. 61: 186–191.Google Scholar
Spritz, N. (1978) Nerve disease in diabetes mellitus. In Symposium on Diabetes Mellitus. Med. Clin. N.A., Podolsky, S. (Ed.), W.B. Saunders, Co., Philadelphia.Google Scholar
Steinke, J. and Thorn, G. (1974) Diabetes mellitus. In Harrison’s Principles of Internal Medicine (7th Edition), Wintrobe, M. et al. (Eds.), McGraw-Hill, New York, pp. 532–50.Google Scholar
Thomas, P.K. and Lascelles, R.G. (1965) Schwann-cell abnormalities in diabetic neuropathy. Lancet, 1: 428–31.Google ScholarPubMed
Warren, S.A. and Warren, K.G. (1981) Multiple sclerosis and associated diseases: a relationship to diabetes mellitus. Can. J. Neur. Sci. 8: 35–39.Google Scholar
Watkins, S. and Espir, M. (1969) Migraine and multiple sclerosis. J. Neuro. Neurosci. Psych. 32: 35–37.CrossRefGoogle ScholarPubMed