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Magnetic Resonance Imaging in the Assessment of Disease Activity in Multiple Sclerosis

  • Donald W. Paty

Abstract:

Magnetic resonance imaging (MRI) has been shown to be a good method of visualizing the lesions in MS. We have studied several applications of MRI to the evaluation of patients and experimental models. In diagnosis, MRI is the most sensitive test for the demonstration of dissemination of lesions in space. Pathological correlation studies show that MRI reliably measures the extent of chronic demyelination. Experimental studies show that MRI detects acute inflammatory lesions and measures their evolution. MRI also is a reliable measure of the extent of the MS process, serial MRI scans detect evidence of disease activity in MS not always disclosed by clinical evaluation. MRI will have an enormous future impact on the evaluation of patients in clinical studies and in understanding the evolution of pathological processes.

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Copyright

Corresponding author

Department of Medicine, Division of Neurology, Vancouver General Hospital, #222 - 2775 Heather St., Vancouver, British Columbia, Canada V5Z 3J5

References

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Magnetic Resonance Imaging in the Assessment of Disease Activity in Multiple Sclerosis

  • Donald W. Paty

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