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Improvement in Severe Orthostatic Hypotension Following Carbidopa Dose Reduction

  • Anthony C.W. Lau (a1), John L. Diggle (a2) (a3) and Penny P. Bring (a4) (a5)
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Abstract

Copyright

Corresponding author

Correspondence to: A.C.W. Lau, BSc (Pharm), Pharmacist, Surrey Memorial Hospital Pharmacy Department, Fraser Health Authority, 13750 96 Avenue, Surrey, BC, Canada V3V 1Z2. Email: Anthony.Lau@fraserhealth.ca

References

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1. DeMaagd, G, Philip, A. Part 2: introduction to the pharmacotherapy of Parkinson’s disease, with a focus on the use of dopaminergic agents. P T. 2015;40(9):590-600.
2. Golan, DE, Tashjian, AH, Armstrong, EJ, Armstrong, AW. Pathophysiologic Basic of Drug Therapy, 3E. Philadelphia, PA: Lippincott Williams & Wilkins; 2012.
3. Carbidopa and levodopa. In: Lexi drugs online. Hudson, OH: Lexicomp Inc.; 2017. Available from: https://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/7167[updated 2017; cited 8 January 2017].
4. Kaufmann, H, Saadia, D, Voustianiouk, A, et al. Norepinephrine precursor therapy in neurogenic orthostatic hypotension. Circulation. 2003;108(6):724-728.
5. Jonkers, N, Sarre, S, Ebinger, G, Michotte, Y. Benserazide decreases central AADC activity, extracellular dopamine levels and levodopa decarboxylation in striatum of the rat. J Neural Transm. 2001;108(5):559-570.
6. Shen, H, Kannari, K, Yamato, H, Arai, A, Matsunaga, M. Effects of benserazide on L-DOPA-derived extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats. Tohoku J Exp Med. 2003;199(3):149-159.
7. Tayarani-Binazir, KA, Jackson, MJ, Fisher, R, Zoubiane, G, Rose, S, Jenner, P. The timing of administration, dose dependence and efficacy of dopa decarboxylase inhibitors on the reversal of motor disability produced by L-DOPA in the MPTP-treated common marmoset. Eur J Pharmacol. 2010;635(1-3):109-116.
8. Naranjo, CA, Busto, U, Sellers, EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239-245.

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