Skip to main content Accessibility help


  • Access
  • Cited by 1


      • Send article to Kindle

        To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

        Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

        Find out more about the Kindle Personal Document Service.

        Geographic Access to Stroke Care Services in Rural Communities in Ontario, Canada
        Available formats

        Send article to Dropbox

        To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

        Geographic Access to Stroke Care Services in Rural Communities in Ontario, Canada
        Available formats

        Send article to Google Drive

        To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

        Geographic Access to Stroke Care Services in Rural Communities in Ontario, Canada
        Available formats
Export citation



Optimal stroke care requires access to resources such as neuroimaging, acute revascularization, rehabilitation, and stroke prevention services, which may not be available in rural areas. We aimed to determine geographic access to stroke care for residents of rural communities in the province of Ontario, Canada.


We used the Ontario Road Network File database linked with the 2016 Ontario Acute Stroke Care Resource Inventory to estimate the proportion of people in rural communities, defined as those with a population size <10,000, who were within 30, 60, and 240 minutes of travel time by car from stroke care services, including brain imaging, thrombolysis treatment centers, stroke units, stroke prevention clinics, inpatient rehabilitation facilities, and endovascular treatment centers.


Of the 1,496,262 people residing in rural communities, the majority resided within 60 minutes of driving time to a center with computed tomography (85%), thrombolysis (81%), a stroke unit (68%), a stroke prevention clinic (74%), or inpatient rehabilitation (77.0%), but a much lower proportion (32%) were within 60 minutes of driving time to a center capable of providing endovascular thrombectomy (EVT).


Most rural Ontario residents have appropriate geographic access to stroke services, with the exception of EVT. This information may be useful for jurisdictions seeking to optimize the regional organization of stroke care services.


Approximately 20% of North Americans live in rural areas, where stroke incidence and mortality are higher than in urban areas.Reference Dwyer, Rehman and Ottavi1Reference Howard, Kleindorfer and Cushman3 Interventions such as thrombolysis, endovascular thrombectomy (EVT), stroke unit care, and rehabilitation are associated with improved outcomes after stroke, but require resources and expertise that are not available in all centers and are less likely to be located in rural areas.Reference Dwyer, Rehman and Ottavi1,Reference Adeoye, Nyström and Yavagal4Reference Fleet, Bussières and Tounkara7 Poor geographic access to medical care has been associated with lower quality of care and with worse outcomes for a variety of medical conditions.Reference Lin, Bruinooge and Kirkwood8,Reference Jones, Haynes, Sauerzapf, Crawford, Zhao and Forman9 Although organized systems of stroke care in Ontario are designed to optimize care across the continuum for an entire region, it is not known whether current stroke systems provide adequate access for residents of rural areas. Previous geospatial analyses have provided important information on access to stroke care across Ontario and Canada, but did not specifically evaluate access to care for rural residents.Reference Jewett, Mirian, Connolly, Silver and Sahlas10Reference Eswaradass, Swartz, Rosen, Hill and Lindsay12

We aimed to quantify geographic access to stroke care for rural residents of Ontario, Canada, using linked population-based administrative data sources to estimate the proportion of people in rural communities who were within 30, 60, and 240 minutes of travel time by car (at posted speed limits) from stroke care services, including neuroimaging, thrombolysis, EVT, stroke unit care, stroke prevention clinics, and inpatient rehabilitation facilities.



Ontario is Canada’s most populous province, with over 13 million people residing in over 1 million square kilometres, and with many smaller communities located far from large medical centers.Reference Glazier, Gozdyra and Yeritsyan13 Ontario has a well-established system of regional stroke care delivery, with a hub-and-spoke model including regional stroke centers with advanced stroke care resources and expertise for thrombolysis and/or EVT, centers capable of facilitating thrombolysis through telemedicine and the Ontario Telestroke Program, district stroke centers capable of providing more basic stroke treatment, and designated stroke secondary prevention clinics. The stroke system incorporates regional transfer agreements and ambulance bypass protocols for the transport of patients with suspected stroke to designated centers. Air ambulances may be used for residents in remote areas. The provincial health insurance plan provides coverage for all hospital and physician services.

Population, Data Sources, and Analyses

We determined the size of the Ontario population in 2016 by summing the populations for each postal code from the 2016 Postal Code Conversion File (PCCF), a digital file of all postal codes linked to census data from Statistics Canada. We used the PCCF to identify communities and their population sizes, and defined rural communities as those with a population size under 10,000.Reference du Plessis, Beshiri, Bollman and Clemenson14 There are various definitions of rurality, some based on population size (with varying sizes used in the literature), some on commuting flow to metropolitan areas, and some on the availability of health care and other resources.Reference Glazier, Gozdyra and Yeritsyan13,15Reference Kralj17 We selected a definition based on a population size under 10,000 as this aligns with the “rural and small town” community size category available in the PCCF datafile.18 We used the 2016 Ontario Stroke Care Resource Inventory, an annual survey of all Ontario acute care institutions, to determine the location of stroke care services. This inventory identifies all rehabilitation facilities, both hospital-based and free-standing, and all designated provincially funded stroke prevention clinics. We then used the PCCF Plus to assign geographic coordinates to postal codes of health services and communities, with each subject within a community assigned the same coordinate, and geocoded locations using ArcGIS version 10.2 by the Environmental Systems Research Institute. Most postal codes representing health care facilities have small areas (mean of 0.04 km2 and median 2.89 km2), as do those representing small populated areas (mean of 0.01 km2 and median 21.06 km2), with the exception of those in the north where population postal codes can represent larger areas.

We used the 2017 Ontario Road Network (ORN) Road Net Element File from Land Information Ontario to provide a listing of Ontario roads with their posted speed limits to calculate travel times by car. We then used network analysis to calculate the travel time from each stroke care service outward through all existing roads using ORN’s posted speed limits. We evaluated access to the following stroke care services: (1) computed tomography (CT); (2) CT angiography (CTA); (3) magnetic resonance imaging (MRI); (4) thrombolysis centers; (5) stroke units; (6) stroke prevention clinics; (7) inpatient rehabilitation facilities; and (8) EVT centers. We calculated the percentage of the rural population with geographic access to the specified services by summing the populations of communities that had access on the road network within the stated travel time and then dividing by the total population of Ontario communities with 10,000 or fewer residents. We performed analyses of the proportion located beyond 240 minutes of driving time stratified by area of residence into northern Ontario, defined as Local Health Integration Network (LHIN) regions 13 and 14, and southern Ontario, defined as LHIN regions 1–12. For endovascular centers and inpatient rehabilitation facilities, we created maps that showed the rural communities located within 30, 60, and 240 minutes of driving time of these services. The use of data in this project was authorized under section 45 of Ontario’s Personal Health Information Protection Act, which does not require review by a Research Ethics Board.


In total, there were 1,496,262 Ontarians living in communities with 10,000 or fewer people, representing 11% of the total population. Over 90% of rural residents lived within 240 minutes of driving time of all stroke care services, with the exception of EVT centers at 83.9% (Table 1 and Figures 14). A substantial proportion of rural residents also lived within 60 minutes of driving time to all stroke care services, at 85.3% for CT, 83.4% for CTA, 92.9% for MRI, 81.3% for thrombolysis centers, 67.9% for stroke units, 73.5% for stroke prevention clinics, and 77.0% for inpatient rehabilitation; the proportion residing within 60 minutes of an EVT center was lower at 32.1% (Table 1 and Figures 14). The proportion of rural residents living within 30 minutes of driving time of stroke care services was generally low, at 61% for CT, 51.1% for CTA, 26.4% for MRI, 29.5% for thrombolysis, 22.0% for stroke units, 27.2% for stroke prevention clinics, 32.6% for inpatient rehabilitation, and only 3.3% for EVT. There were marked regional variations in geographic access, with many northern Ontario rural communities located beyond 240 minutes of driving time of stroke care services (Figures 14). No southern Ontario residents lived beyond 240 minutes of driving time of any stroke care services; in contrast, the proportion of rural residents in northern Ontario living beyond 240 minutes of driving time was 8.7% for CT, 28.4% for MRI, 9.0% for CTA, 9.0% for thrombolysis, 33.9% for stroke units, 8.9% for stroke prevention clinics, 28.3% for inpatient rehabilitation, and 73.9% for EVT (Table 2).

Table 1: Percentage of population in rural communities in Ontario, Canada, with access to various stroke care services within 30, 60, and 240 minutes of travel time by car

CT = computed tomography; MRI = magnetic resonance imaging; CTA = CT angiography; endovascular center = center with the capacity to perform mechanical thrombectomy.

Rural population defined as those residing in a community with 10,000 or fewer residents.

Figure 1: Map of rural communities (population size less than 10,000) in Northern Ontario within 30, 60, and 240 minutes of driving time to the nearest hospital (N = 1) providing endovascular thrombectomy.

Figure 2: Map of rural communities (population size less than 10,000) in Southern Ontario within 30, 60, and 240 minutes of driving time to the nearest hospital (N = 10) providing endovascular thrombectomy.

Figure 3: Map of rural communities (population size less than 10,000) in Northern Ontario within 30, 60, and 240 minutes of driving time to the nearest hospital providing inpatient rehabilitation.

Figure 4: Map of rural communities (population size less than 10,000) in Southern Ontario within 30, 60, and 240 minutes of driving time to the nearest hospital providing inpatient rehabilitation.

Table 2: Percentage of population in rural communities in Ontario, Canada, beyond 240 minutes of driving time to various stroke care services, stratified into northern and southern Ontario regions

CT = computed tomography; MRI = magnetic resonance imaging; CTA = CT angiography; endovascular center = center with the capacity to perform mechanical thrombectomy.

Rural population defined as those residing in a community with 10,000 or fewer residents.

Northern Ontario defined as Local Health Integration Network (LHIN) regions 13 and 14; Southern Ontario defined as LHIN regions 1–12.


We found that the majority of rural residents in Ontario lived within 60 minutes of driving time from key stroke services, including neuroimaging and thrombolysis. However, geographic access was substantially lower for EVT, and many rural communities in northern Ontario did not have timely road access to any stroke services.

Previous studies evaluating geographic access to stroke services have estimated that over 80% of the US population has access to thrombolysis-capable hospitals within 60 minutes, with similar results seen in Ontario and other Canadian provinces.Reference Jewett, Mirian, Connolly, Silver and Sahlas10,Reference Eswaradass, Swartz, Rosen, Hill and Lindsay12,Reference Adeoye, Albright and Carr19 However, these studies assessed the entire population rather than rural communities, where access might be anticipated to be lower. Our finding that over 81% of rural residents lived within 60 minutes of driving time to thrombolysis centers provides evidence of very good rural access to this treatment. This is consistent with previously observed high thrombolysis treatment rates in both rural and urban areas of Ontario, and with elimination of rural/urban disparities in use over time, and may reflect the impact of a well-established regional system of coordinated stroke care in Ontario for this treatment.Reference Gonzales, Mullen, Skolarus, Thibault, Udoeyo and Willis20Reference Kapral, Fang and Silver22

Most existing systems of stroke care were developed prior to the demonstration of the effectiveness of EVT for acute ischemic stroke and were therefore not designed to ensure equitable access to this treatment.Reference Adeoye, Nyström and Yavagal4,Reference Grotta23 Studies from the USA have documented marked geographic variations in access to care, with lower access in states with a large proportion of rural residents.Reference Adeoye, Albright and Carr19,Reference Mullen, Branas and Kasner24 Our findings suggest that the majority of rural Ontarians cannot reach existing EVT centers within 60 minutes of driving time, and that the proportion living within 30 minutes of driving time is exceedingly small at 3.3%. Further, EVT is only indicated in patients with large vessel occlusion, which is estimated to be present in only 20% of patients with stroke.Reference Malhotra, Gornbein and Saver25 Identifying the presence of large vessel occlusion requires CTA, and the ability of only 51.1% of the population to reach this imaging modality within 30 minutes of driving time limits the ability to systematically screen potential EVT candidates and may result in suboptimal use of treatment and transportation resources. Although EVT can be provided to selected patients up to 24 hours after stroke symptom onset, outcomes are better with early therapy, so timely access is essential.Reference Meretoja, Keshtkaran, Tatlisumak, Donnan and Churilov26,Reference Mulder, Jansen and Goldhoorn27 Furthermore, patient selection in the post-6-hour window is based on CT perfusion imaging that is currently not available in most Ontario hospitals.Reference Albers, Marks and Lansberg28

Potential solutions to improve rural EVT access include promoting the use of emergency medical services for acute stroke, as previous research suggests that rural residents with suspected stroke are less likely than those in large urban centers to arrive at hospital by ambulance.Reference Koifman, Hall and Li21 For some remote communities, the use of air rather than ground transportation will be necessary, although factors such as availability of aircraft, airports, and fly time from base to community may all affect transit times, and air transportation may be particularly unreliable in northern communities because of poor weather. Other potential solutions include the use of mobile stroke units, prehospital triage, telemedicine for decision support, and flying intervention teams.Reference Fassbender, Grotta, Walter, Grunwald, Ragoschke-Schumm and Saver29Reference Shuaib and Jeerakathil36 Direct transportation to intervention centers may be preferable to interhospital transfers, which can be associated with delays in treatment and worse outcomes.Reference Grotta23,Reference Shah, Xian and Sheng37Reference Allen, Pearn and James39 The designation of additional endovascular centers in underserved areas may be part of the solution, although it may be challenging to maintain a roster of staff and neurocritical care services in such areas, and one Korean study found that outcomes were worse at small-volume compared to large-volume sites.Reference Kim, Baek, Heo, Kim, Nam and Kim40 Finally, allowing patients to seek care across provincial boundaries may reduce travel time to stroke care services.Reference Jewett, Harroud and Hill11

Geographic access is important not only for time-sensitive hyperacute stroke interventions, but also for rehabilitation and stroke secondary prevention. Patients whose only access to rehabilitation facilities is many hours of drive from their home communities may opt to forgo inpatient rehabilitation because of the distance from family and other supports, potentially squandering initial gains from acute stroke care. Minor strokes and transient ischemic attacks make up over half of the burden of ischemic cerebrovascular diseases and are harbingers of potentially preventable larger disabling strokes, and long driving times to stroke prevention clinics limit the ability to provide rapid outpatient diagnostic testing and management to reduce the risk of stroke in this group.Reference Giles and Rothwell41 Our findings suggest that over one in five rural Ontarians are beyond 60 minutes of driving time of inpatient rehabilitation and stroke prevention clinics, and are consistent with a previous study that found that only 69% of Canadians had access to secondary prevention services that were operational 5 to 7 days a week.Reference Jewett, Harroud and Hill11

Some rural communities are in close proximity to metropolitan areas while others are in remote northern locations. Not surprisingly, we found that geographic access by car was particularly low in northern Ontario, with a substantial proportion of residents living beyond 240 minutes of driving time of key stroke services. Many of these communities will always require air transportation for care for medical emergencies; however, the targeted designation of additional facilities may improve access in such areas. Currently, there is only one endovascular center in northern Ontario, but a second site is now being developed. Other potential strategies to improve access to care in remote areas include the use of telemedicine (including innovative technology that allows procedures to be performed remotely), telerehabilitation, and rural stroke coordinators in strategic locations.Reference Cadhilac, Purvis and Kilkenny42Reference Housley, Garlow and Ducote44

A number of study limitations merit comment. Our findings are specific to the geography and health system in the province of Ontario. However, we anticipate that these will be applicable to other jurisdictions with hub-and-spoke models of stroke care covering large distances and encompassing both rural and urban areas. Most of the postal codes in our study represented fairly confined geographic areas, with the exception of some postal codes in northern areas where population postal codes could represent larger geographic areas. Although this introduces uncertainty to the estimation of drive times in the north, any potential bias would be minimized by the fact that these postal codes are all located well beyond 60 minutes of driving time to the nearest health care facility, and thus our conclusions are unlikely to be affected by errors in estimated travel time based on postal code representation. Although the Acute Stroke Care Resource Inventory identified all designated stroke prevention clinics, stroke secondary prevention care may have been delivered through other mechanisms, such as cardiology clinics or individual clinicians’ offices. We did not study actual delivery of stroke care, but only geographic access to services. For example, we evaluated geographic access to facilities with the capacity to perform CT; however, not all of these provide daily round-the-clock service, and even those that do may require a technologist to travel from home, thus introducing further delays. Fourth, our analyses focused on driving times based on posted speed limits; however, actual driving speeds will be higher than posted ones for emergency vehicles and lower during difficult weather conditions or heavy traffic.Reference Freyssenge, Renard and Schott45 Not all people have access to vehicles, and use of driving time as a surrogate for access may overestimate access to care, especially in subgroups of people with lower car ownership.Reference Wong, Grande and Mitra46,Reference Fone, Christie and Lester47 True transit time includes not only driving time but also emergency medical services activation time, response time, on-scene time, and “door-in door-out” times for those seen first at a local hospital and subsequently transferred to a stroke center.Reference Carr, Caplan, Pryor and Branas48 For all of these reasons, our findings are likely to overestimate rural communities’ geographic access to stroke services. Fifth, we did not study issues specifically related to Indigenous people, who are more likely than their non-Indigenous counterparts to live in rural areas, and who may face additional barriers to care related to the historic effects of colonization.Reference Slater, Green and Shah49,Reference King, Smith and Gracey50 Finally, this study focused solely on rural communities, and thus the findings differ from those of studies of geographic access for all communities in the province.

This study provides evidence of very good overall geographic access to CT and thrombolysis from rural communities across Ontario. However, targeted solutions are needed to improve rural access to other stroke services, particularly EVT, and to improve access in northern Ontario.


This study was supported by ICES, which is funded by an annual grant from the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions reported in this paper are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and/or information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed in the material are those of the author(s), and not necessarily those of CIHI.


This study was supported by a grant-in-aid from the Heart and Stroke Foundation of Canada (HSFC GID16-13790). Moira Kapral is supported by a Mid-Career Investigator Award, Peter Austin by a Mid-Career Investigator Award, and Richard Swartz by a New Investigator Award and a Clinician-Scientist Phase II Award, all from the Heart and Stroke Foundation of Canada, Ontario Provincial Office.



Statement of Authorship

MKK drafted the manuscript. PG and JF performed the statistical analyses. All authors contributed to the study design, interpretation of the analyses, and revisions of the manuscript.


1.Dwyer, M, Rehman, S, Ottavi, T, et al.Urban-rural differences in the care and outcomes of acute stroke patients: systematic review. J Neurol Sci. 2019;397:6374.
2.Kapral, MK, Austin, PC, Jeyakumar, G, et al.Rural-urban differences in stroke risk factors, incidence, and mortality in people with and without prior stroke. Circ Cardiovasc Qual Outcomes. 2019;12(2):e004973.10.1161/CIRCOUTCOMES.118.004973
3.Howard, G, Kleindorfer, DO, Cushman, M, et al.Contributors to the excess stroke mortality in rural areas in the United States. Stroke. 2017;48(7):1773–8.
4.Adeoye, O, Nyström, KV, Yavagal, DR, et al. Recommendations for the establishment of stroke systems of care: a 2019 update: a policy statement from the American Stroke Association. Stroke. 2019:STR0000000000000173.
5.Leira, EC, Hess, DC, Torner, JC, Adams, HP. Rural-urban differences in acute stroke management practices: a modifiable disparity. Arch Neurol. 2008;65(7):887–91.10.1001/archneur.65.7.887
6.Jia, H, Cowper, DC, Tang, Y, Litt, E, Wilson, L. Postacute stroke rehabilitation utilization: are there differences between rural-urban patients and taxonomies? J Rural Health. 2012;28(3):242247.
7.Fleet, R, Bussières, S, Tounkara, FK, et al.Rural versus urban academic hospital mortality following stroke in Canada. PLoS One. 2018;13(1):e0191151.
8.Lin, CC, Bruinooge, SS, Kirkwood, MK, et al.Association between geographic access to cancer care and receipt of radiation therapy for rectal cancer. Int J Radiat Oncol Biol Phys. 2016;94(4):719–28.
9.Jones, AP, Haynes, R, Sauerzapf, V, Crawford, SM, Zhao, H, Forman, D. Travel times to health care and survival from cancers in Northern England. Eur J Cancer. 2008;44(2):269–74.10.1016/j.ejca.2007.07.028
10.Jewett, L, Mirian, A, Connolly, B, Silver, FL, Sahlas, DJ. Use of geospatial modeling to evaluate the impact of telestroke on access to stroke thrombolysis in Ontario. J Stroke Cerebrovasc Dis. 2017;26(7):1400–6.
11.Jewett, L, Harroud, A, Hill, MD, et al.Secondary stroke prevention services in Canada: a cross-sectional survey and geospatial analysis of resources, capacity and geographic access. CMAJ Open. 2018;6(1):E95102.10.9778/cmajo.20170130
12.Eswaradass, PV, Swartz, RH, Rosen, J, Hill, MD, Lindsay, MP. Access to hyperacute stroke services across Canadian provinces: a geospatial analysis. CMAJ Open. 2017;5(2):E4549.10.9778/cmajo.20160166
13.Glazier, R, Gozdyra, P, Yeritsyan, N. Geographic access to primary care and hospital services for rural and northern communities: report to the Ontario Ministry of Health and Long-Term Care. Toronto; Institute for Clinical Evaluative Sciences: 2011.
14.du Plessis, V, Beshiri, R, Bollman, R, Clemenson, H. Statistics Canada agriculture and rural working paper no. 61: definitions of “rural”; 2002. Available at:; accessed June 27, 2017.
15.Canadian Population Health Initiative. How healthy are rural Canadians? An assessment of their health status and health determinants; 2006.
16.McNiven, C, Puderer, H, Janes, D. Census metropolitan area and census agglomeration influenced zones (MIZ): a description of the methodology; 2000. Available at:; accessed November 21, 2019.
17.Kralj, B. Measuring “rurality” for the purposes of health-care planning: an empirical measure for Ontario; 2000. Ontario Medical Review web site. Available at:; accessed November 21, 2019.
18.Statistics Canada. Postal code conversion file plus (PCCF+) version 7A. Reference Guide; 2017. Available at:; accessed November 21, 2019.
19.Adeoye, O, Albright, KC, Carr, BG, et al.Geographic access to acute stroke care in the United States. Stroke. 2014;45(10):3019–24.10.1161/STROKEAHA.114.006293
20.Gonzales, S, Mullen, MT, Skolarus, L, Thibault, DP, Udoeyo, U, Willis, AW. Progressive rural-urban disparity in acute stroke care. Neurology. 2017;88(5):441–8.
21.Koifman, J, Hall, R, Li, S, et al.The association between rural residence and stroke care and outcomes. J Neurol Sci. 2016;363:1620.10.1016/j.jns.2016.02.019
22.Kapral, MK, Fang, J, Silver, FL, et al.Effect of a provincial system of stroke care delivery on stroke care and outcomes. CMAJ. 2013;185(10):E48391.10.1503/cmaj.121418
23.Grotta, JC. Interhospital transfer of stroke patients for endovascular treatment. Circulation. 2019;139(13):1578–80.
24.Mullen, MT, Branas, CC, Kasner, SE, et al.Optimization modeling to maximize population access to comprehensive stroke centers. Neurology. 2015;84(12):1196–205.
25.Malhotra, K, Gornbein, J, Saver, JL. Ischemic strokes due to large-vessel occlusions contribute disproportionately to stroke-related dependence and death: a review. Front Neurol. 2017;8:651.
26.Meretoja, A, Keshtkaran, M, Tatlisumak, T, Donnan, GA, Churilov, L. Endovascular therapy for ischemic stroke: save a minute-save a week. Neurology. 2017;88(22):2123–7.10.1212/WNL.0000000000003981
27.Mulder, MJHL, Jansen, IGH, Goldhoorn, RB, et al.Time to endovascular treatment and outcome in acute ischemic stroke: MR CLEAN registry results. Circulation. 2018;138(3):232–40.
28.Albers, GW, Marks, MP, Lansberg, MG. Thrombectomy for stroke with selection by perfusion imaging. N Engl J Med. 2018;378(19):1849–50.10.1056/NEJMoa1713973
29.Fassbender, K, Grotta, JC, Walter, S, Grunwald, IQ, Ragoschke-Schumm, A, Saver, JL. Mobile stroke units for prehospital thrombolysis, triage, and beyond: benefits and challenges. Lancet Neurol. 2017;16(3):227–37.
30.Mathur, S, Walter, S, Grunwald, IQ, Helwig, SA, Lesmeister, M, Fassbender, K. Improving prehospital stroke services in rural and underserved settings with mobile stroke units. Front Neurol. 2019;10:159.10.3389/fneur.2019.00159
31.Walter, S, Zhao, H, Easton, D, et al.Air-Mobile Stroke Unit for access to stroke treatment in rural regions. Int J Stroke. 2018;13(6):568–75.
32.Kunz, A, Ebinger, M, Geisler, F, et al.Functional outcomes of pre-hospital thrombolysis in a mobile stroke treatment unit compared with conventional care: an observational registry study. Lancet Neurol. 2016;15(10):1035–43.
33.Audebert, H, Fassbender, K, Hussain, MS, et al.The PRE-hospital stroke treatment organization. Int J Stroke. 2017;12(9):932–40.10.1177/1747493017729268
34.Leira, EC, Stilley, JD, Schnell, T, Audebert, HJ, Adams, HP. Helicopter transportation in the era of thrombectomy: the next frontier for acute stroke treatment and research. Eur Stroke J. 2016;1(3):171–9.10.1177/2396987316658994
35.Barlinn, J, Gerber, J, Barlinn, K, et al.Acute endovascular treatment delivery to ischemic stroke patients transferred within a telestroke network: a retrospective observational study. Int J Stroke. 2017;12(5):502–9.
36.Shuaib, A, Jeerakathil, T, Investigators AMSU. The mobile stroke unit and management of acute stroke in rural settings. CMAJ. 2018;190(28):E8558.10.1503/cmaj.170999
37.Shah, S, Xian, Y, Sheng, S, et al.Use, temporal trends, and outcomes of endovascular therapy after interhospital transfer in the United States. Circulation. 2019;139(13):1568–77.10.1161/CIRCULATIONAHA.118.036509
38.Venema, E, Groot, AE, Lingsma, HF, et al.Effect of interhospital transfer on endovascular treatment for acute ischemic stroke. Stroke. 2019;50(4):923–30.
39.Allen, M, Pearn, K, James, M, et al.Maximising access to thrombectomy services for stroke in England: a modelling study. Eur Stroke J. 2019;4(1):3949.10.1177/2396987318785421
40.Kim, BM, Baek, JH, Heo, JH, Kim, DJ, Nam, HS, Kim, YD. Effect of cumulative case volume on procedural and clinical outcomes in endovascular thrombectomy. Stroke. 2019;50(5):1178–83.
41.Giles, MF, Rothwell, PM. Risk of stroke early after transient ischemic attack: a systematic review and meta-analysis. Lancet Neurology. 2007;6:10631072.
42.Cadhilac, DA, Purvis, T, Kilkenny, MFet al.Evaluation of rural stroke services: does implementation of coordinators and pathways improve care in rural hospitals? Stroke. 2013;44:2848–53.
43.Johansson, T, Wild, C. Telerehabilitation in stroke care – a systematic review. J Telemed Telecare. 2011;17(1):16.10.1258/jtt.2010.100105
44.Housley, SN, Garlow, AR, Ducote, K, et al.Increasing access to cost effective home-based rehabilitation for rural veteran stroke survivors. Austin J Cerebrovasc Dis Stroke. 2016;3(2):111.
45.Freyssenge, J, Renard, F, Schott, AM, et al.Measurement of the potential geographic accessibility from call to definitive care for patient with acute stroke. Int J Health Geogr. 2018;17(1):1.10.1186/s12942-018-0121-4
46.Wong, MS, Grande, DT, Mitra, N, et al.Racial differences in geographic access to medical care as measured by patient report and geographic information systems. Med Care. 2017;55(9):817–22.
47.Fone, DL, Christie, S, Lester, N. Comparison of perceived and modelled geographical access to accident and emergency departments: a cross-sectional analysis from the Caerphilly Health and Social Needs Study. Int J Health Geogr. 2006;5:16.10.1186/1476-072X-5-16
48.Carr, BG, Caplan, JM, Pryor, JP, Branas, CC. A meta-analysis of prehospital care times for trauma. Prehosp Emerg Care. 2006;10(2):198206.
49.Slater, M, Green, ME, Shah, B, et al.First Nations people with diabetes in Ontario: methods for a longitudinal population-based cohort study. CMAJ Open. 2019;7(4):E680E688.
50.King, M, Smith, A, Gracey, M. Indigenous health part 2: the underlying causes of the health gap. Lancet. 2009;374(9683):7685.