Hostname: page-component-7c8c6479df-7qhmt Total loading time: 0 Render date: 2024-03-18T01:52:44.324Z Has data issue: false hasContentIssue false

The Genetics of Parkinson Disease: To Test or Not to Test

Published online by Cambridge University Press:  02 December 2014

Oksana Suchowersky*
Affiliation:
Calgary, Alberta
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Editorial
Copyright
Copyright © The Canadian Journal of Neurological 2007

References

1. Semchuk, KM, Love, EJ, Lee, RG. Parkinson’s disease: a test of the multifactorial etiologic hypothesis. Neurology. 1993;43(6):117380.CrossRefGoogle ScholarPubMed
2. Polymeropoulos, MH, lavedan, C, Leroyt, E, Ide, SE, Dehejia, A, Dutra, A, et al. Mutation in the α-synuclein gene identified in families with Parkinson’s disease. Science. 1997;276:20457.CrossRefGoogle ScholarPubMed
3. Klein, C, Schlossmacher, MG. The genetics of Parkinson disease: implications for neurological care. Nat Clin Prac Neurol. March 2006;2:13646.CrossRefGoogle ScholarPubMed
4. Zimprich, A, Bisup, S, Leitner, P, Lichtner, P, Farrer, M, Lincoln, S, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron. 2004;44:6017.CrossRefGoogle ScholarPubMed
5. Dupré, N, Rivière, J, Myers, RM, Provencher, P, Pourcher, E, Emond, F, Rouleau, GA. LRRK2 is not a significant cause of Parkinson’s disease in French-Canadians. Can J Neurol Sci. 2007;34:3335.CrossRefGoogle Scholar
6. Grimes, DA, Racacho, L, Han, F, Panisset, M, Bulman, DE. LLRK2 Screening in a Canadian Parkinson’s disease cohort. Can J Neurol Sci. 2007;34:3368.CrossRefGoogle Scholar