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Five-Year Incidence of Amyotrophic Lateral Sclerosis in British Columbia (2010-2015)

  • Riley Golby (a1), Brigitte Poirier (a2), Marife Fabros (a3), Jacquelyn J. Cragg (a4), Masoud Yousefi (a5) and Neil Cashman (a3) (a6)...

Abstract

Background: Amyotrophic lateral sclerosis (ALS) is a fatal degenerative neurological disease with significant effects on quality of life. International studies continue to provide consistent incidence values, though complete case ascertainment remains a challenge. The Canadian population has been understudied, and there are currently no quantitative data on the incidence of ALS in British Columbia (BC). The objectives of this study were to determine the five-year incidence rates of ALS in BC and to characterize the demographic patterns of the disease. Methods: The capture–recapture method was employed to estimate ALS incidence over a five-year period (2010-2015). Two sources were used to identify ALS cases: one database from an ALS medical centre and another from a not-for-profit ALS organization. Results: During this time period, there were 690 incident cases within the two sources. The capture–recapture method estimated 57 unobserved cases, corresponding to a crude five-year incidence rate of 3.29 cases per 100,000 (CI 95%=3.05-3.53). The mean age of diagnosis was 64.6 (CI 95%=59.7-69.4), with 63.5 (CI 95%=56.9-70.1) for men and 65.7 (CI 95%=58.6-72.7) for women. There was a slight male preponderance in incidence, with a 1.05:1 ratio to females. Peak numbers in incidence occurred between the ages of 70 and 79. Conclusions: The incidence of ALS in BC was found to be consistent with international findings though nominally higher than that in other Canadian provinces to date.

Taux d’incidence de la sclérose latérale amyotrophique en Colombie-Britannique de 2010 à 2015. Contexte: La sclérose latérale amyotrophique (SLA) est une maladie neurologique dégénérative qui à terme cause la mort et dont les effets sur la qualité de vie sont notables. Bien que des études internationales continuent de fournir des données cohérentes quant à l’incidence de la SLA, une évaluation complète de cette maladie demeure toujours un défi. À cet égard, la population canadienne n’a pas été suffisamment étudiée ; il n’existe pas non plus, à l’heure actuelle, de données quantitatives en ce qui regarde l’incidence de la SLA en Colombie-Britannique (C.-B.). L’objectif de cette étude a donc été de déterminer sur cinq ans le taux d’incidence de la SLA en C.-B. et de caractériser les aspects démographiques de cette maladie. Méthodes: Nous avons utilisé la méthode de capture–recapture pour estimer l’incidence de la SLA sur une période de cinq ans (2010–2015). Pour ce faire, nous avons exploré deux bases de données, l’une produite par un centre médical spécialisé et l’autre par une organisation sans but lucratif, afin de relever des cas de SLA. Résultats: Au cours de cette période, ces deux bases de données ont révélé 690 cas. La méthode de capture–recapture a aussi estimé que 57 cas n’avaient pas été observés, ce qui correspond, sur cinq ans, à un taux d’incidence brut de 3,29 cas pour 100 000 (IC95% = 3,05 – 3,53). L’âge moyen au moment du diagnostic était de 64,6 ans (IC95% = 59,7 – 69,4), soit 63,5 ans (IC95% = 56,9 – 70,1) pour les hommes et 65,7 ans (IC95% = 58,6 – 72,7) pour les femmes. De plus, le taux d’incidence des hommes est apparu légèrement plus élevé, le rapport hommes/femmes étant de 1,05:1. Enfin, soulignons que le plus grand nombre de cas surviennent entre 70 et 79 ans. Conclusions: Il a été constaté que l’incidence de la SLA en C.-B. équivaut à celle observée sur le plan international. À ce jour, elle est aussi nominalement plus élevée que dans les autres provinces canadiennes.

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Copyright

Corresponding author

Correspondence to: Riley Golby, School of Medicine, University of British Columbia, #407 3278 Heather Street, Vancouver, British Columbia, Canada V5Z 4R9. Email: riley.golby@alumni.ubc.ca.

References

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