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Environment, Genetics and Idiopathic Parkinson's Disease

Published online by Cambridge University Press:  18 September 2015

Judes Poirier*
McGill Centre For Studies in Aging, Montreal The Douglas Hospital Research Centre, Verdun
Sandra Kogan
McGill Centre For Studies in Aging, Montreal
Serge Gauthier
McGill Centre For Studies in Aging, Montreal
The McGill Centre For Studies in Aging, Montreal General Hospital, 1650 Cedar Ave., Montréal, Québec, Canada H3G 1A4
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Since Idiopathic Parkinson's disease (IPD) was first described more than 170 years ago, there have been major advances in the understanding of the etiology of the disease as well as in its treatment. This article will review current knowledge concerning the role of the environment, genetic hypotheses and the aging factor in the etiology of IPD and proposes a complex interaction involving all these factors. Hypotheses regarding mitochondrial inhibition and free radical generation in IPD are discussed in relation to the mechanism of action of neurotoxins known to produce parkinsonian syndromes.

Focus on Parkinson's Disease
Copyright © Canadian Neurological Sciences Federation 1991


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