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Elevated Free Fatty Acid is Associated with Cardioembolic Stroke Subtype

Published online by Cambridge University Press:  02 December 2014

Woo-Keun Seo*
Department of Neurology, Korea University Guro Hospital, Korea University, Seouol, Korea
Juyeon Kim
Department of Neurology, Korea University Guro Hospital, Korea University, Seouol, Korea
Yoo Hwan Kim
Department of Neurology, Korea University Guro Hospital, Korea University, Seouol, Korea
Ji Hyun Kim
Department of Neurology, Korea University Guro Hospital, Korea University, Seouol, Korea
Kyungmi Oh
Department of Neurology, Korea University Guro Hospital, Korea University, Seouol, Korea
Seong-Beom Koh
Department of Neurology, Korea University Guro Hospital, Korea University, Seouol, Korea
Hong Seok Seo
Division of Cardiology, Department of Internal Medicine, College of Medicine, Korea University Guro Hospital, Korea University, Seouol, Korea
Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, #80, Guro-dong, Guro-gu, Seoul 152-703, Korea.
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Background and Objectives:

Free fatty acids (FFAs), an important energy substrate, have an association with cardiovascular diseases, such as atherosclerosis, myocardial dysfunction and abnormal cardiac rhythm. However, limited reports are available on the association between FFAs and ischemic stroke. We hypothesized that plasma FFA concentration could be associated with an ischemic stroke, emphasizing the relationship between FFA and subtypes of ischemic stroke.


A cross-sectional study examined the association between FFA concentration and subtypes of stroke and cerebral atherosclerosis from a hospital-based acute stroke registry.


Data of 715 stroke patients were analyzed. The concentration of FFA was highest in the cardioembolic stroke subtype compared with the other stroke subtypes. Logistic regression analysis revealed that an increase in FFA concentration was significantly associated with the cardioembolic subtype after the adjustment of covariates. FFA concentration was also higher in patients with atrial fibrillation (AF) than those without AF. According to the presence of atherosclerotic stenosis, no significantly difference of FFA concentration was found for intracranial and extracranial cerebral arterial atherosclerosis.


Here we report a significant association between fasting FFA concentration and the cardioembolic stroke subtype. AF is suggested as the mediating factor between FFA and the cardioembolic stroke subtype.

Original Articles
Copyright © The Canadian Journal of Neurological 2011


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