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Effect of Phenytoin on Protein Binding of Valproic Acid
Published online by Cambridge University Press: 18 September 2015
Summary:
In vitro experiments using the equilibrium dialysis technique were performed to determine the binding of valproic acid to plasma components in the absence and presence of therapeutic concentrations of phenytoin. The free fraction of valproic acid was found to be dependent on the total valproic acid concentration. Phenytoin did not influence valproic acid protein binding.
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- Research Article
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- Copyright © Canadian Neurological Sciences Federation 1979
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