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Eagle Syndrome as a Cause of Cerebral Venous Sinus Thrombosis

  • Fu-Liang Zhang (a1), Hong-Wei Zhou (a2), Zhen-Ni Guo (a3) and Yi Yang (a1) (a3)


A 15-year-old teenager presented with a 2-month history of headache. Neurological examination was normal except for papilledema. Further lumbar puncture indicated intracranial hypertension (330 mm H2O). Brain magnetic resonance imaging (MRI) was normal but phase contrast-magnetic resonance venography (PC-MRV) (Figure 1(A)) suggested possible left transverse-sigmoid sinus thrombosis; subsequent contrast-enhanced 3D fat-saturated T1 volumetric isotropic turbo spin echo acquisition (VISTA) MRI (Figure 1(B)) confirmed the pathology. Hyper-coagulable panel results (including six steroid sex hormones, antithrombin III, protein C, protein S, lupus anticoagulant, and anticardiolipin antibodies) were all within normal range. In further examination, computed tomography (CT) venography images (Figure 1(C) and (D)) showed that the left jugular vein was compressed by the styloid process, consistent with Eagle syndrome.1 The patient who refused the recommended surgical treatment, however, chose anticoagulant therapy consisting of low-molecular weight heparin subcutaneous injection in addition to new oral anticoagulant. At 18-month follow-up, the patient reported no symptoms remained.


Corresponding author

Correspondence to: Yi Yang, Department of Neurology, Stroke Center, Neuroscience Center & Clinical Trial and Research Center for Stroke, The First Hospital of Jilin University, Xinmin Street 71#, Changchun, Jilin 130021, China. Email:;


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These two authors contributed equally to the manuscript.



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1.Badhey, A, Jategaonkar, A, Anglin Kovacs, AJ, et al. Eagle syndrome: a comprehensive review. Clin Neurol Neurosurg. 2017;159:34–8.
2.Eagle, WW. Elongated styloid processes: report of two cases. Arch Otolaryngol. 1937;25(5):584–7.
3.Aydin, E, Quliyev, H, Cinar, C, Bozkaya, H, Oran, I. Eagle syndrome presenting with neurological symptoms. Turk Neurosurg. 2018;28(2):219–25.
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Canadian Journal of Neurological Sciences
  • ISSN: 0317-1671
  • EISSN: 2057-0155
  • URL: /core/journals/canadian-journal-of-neurological-sciences
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