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During Repetitive Forebrain Ischemia, Post-ischemic Hypothermia Protects Neurons from Damage

Published online by Cambridge University Press:  18 September 2015

Ashfaq Shuaib ,
Sadiq Ijaz ,
Jay Kalra  and
William Code
Ashfaq Shuaib*
Affiliation:
Departments of Medicine (Division of Neurology), College of Medicine, University of Saskatchewan, Saskatoon
Sadiq Ijaz
Affiliation:
Anesthesia, Cerebrovasular Research Laboratory, College of Medicine, University of Saskatchewan, Saskatoon
Jay Kalra
Affiliation:
Pathology, College of Medicine, University of Saskatchewan, Saskatoon
William Code
Affiliation:
Saskatchewan Stroke Research Centre, College of Medicine, University of Saskatchewan, Saskatoon
*
Dept. of Medicine, Royal University Hospital, Saskatoon, Saskatchewan, Canada S7N 0X0
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Abstract:

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In rodents damage from repetitive transient cerebral ischemia is more severe than that seen with a single ischemic insult of similar duration. Mild hypothermia has been shown to be very effective in protecting the brain during single ischemic insults. We tested the protective effects of hypothermia in repetitive ischemic insults. We used the gerbil model of repetitive ischemia (three minutes ischemia repeated at one hourly intervals three times) and histological evaluation was done using the silver staining technique. Our study reveals that a decrease in body and scalp temperature by 1-2 degrees Celsius can significantly reduce neuronal damage in the cerebral cortex, CA1 region of the hippocampus and substantia nigra reticulata during repetitive ischemia. As the hypothermia was induced after the initial insult, we believe this offers an opportunity for intervention in the clinical settings.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 4 , November 1992 , pp. 428 - 432
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

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