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Current Concepts in the Neuropathology and Pathogenesis of Multiple Sclerosis

  • G.R. Wayne Moore (a1)

Abstract:

Multiple sclerosis (MS) has been classically regarded as an inflammatory demyelinating disease of the central nervous system. In recent years, the classification and pathogenesis of the disease have become controversial, particularly with respect to whether an individual patient demonstrates a single or multiple pathogenetic mechanisms in the establishment of the focal plaque of MS. It is also becoming increasingly apparent that there is a significant neurodegenerative component in the disease, involving not only plaques but the non-plaque parenchyma as well. Magnetic resonance imaging, together with histopathologic studies, will continue to shed light on the pathogenesis of these focal and diffuse abnormalities in MS.

RÉSUMÉ:

La sclérose en plaques (SP) est considérée comme une maladie démyélinisante inflammatoire du système nerveux central. Au cours des dernières années, la classification et la pathogenèse de la maladie ont fait l'objet de controverses, particulièrement en ce qui concerne la présence d'un ou de plusieurs mécanismes pathogènes dans la formation de la plaque focale de la SP. Il est de plus en plus évident qu'il existe une composante neurodégénérative significative dans cette maladie, impliquant non seulement les plaques mais aussi le parenchyme exempt de plaques. L'IRM a contribué et, conjointement avec les études anatomopathologiques, continuera à élucider la pathogenèse de ces anomalies focales et diffuses dans la SP.

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Corresponding author

Room 5450, Blusson Spinal Cord Centre, ICORD (International Collaboration on Repair Discoveries), 818 West 10th Avenue, Vancouver, British Columbia, V5Z 1M9, Canada.

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Current Concepts in the Neuropathology and Pathogenesis of Multiple Sclerosis

  • G.R. Wayne Moore (a1)

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