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Contrast Enhancing Lesions in Progressive Multifocal Leukoencephalopathy: A Clinicopathological Correlation

Published online by Cambridge University Press:  18 September 2015

Bronislava Shafran ,
Marian E. Roke ,
Robert M. Barr  and
J. Gregory Cairncross
Bronislava Shafran*
Affiliation:
Departments of Clinical Neurological Sciences, Medicine, Pathology and Radiation Oncology, University of Western Ontario, and The London Regional Cancer Centre, London
Marian E. Roke
Affiliation:
Departments of Clinical Neurological Sciences, Medicine, Pathology and Radiation Oncology, University of Western Ontario, and The London Regional Cancer Centre, London
Robert M. Barr
Affiliation:
Departments of Clinical Neurological Sciences, Medicine, Pathology and Radiation Oncology, University of Western Ontario, and The London Regional Cancer Centre, London
J. Gregory Cairncross
Affiliation:
Departments of Clinical Neurological Sciences, Medicine, Pathology and Radiation Oncology, University of Western Ontario, and The London Regional Cancer Centre, London
*
The London Regional Cancer Centre, 391 South Street, London, Ontario, Canada N6A 4G5
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Abstract:

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A 60 year old man with chronic lymphocytic leukemia (CLL) developed a subacute neurological illness associated with multiple contrast enhancing lesions on CT scan. At autopsy large demyelinating lesions characteristic of progressive multifocal leukoencephalopathy (PML) were found in the right cerebral hemisphere surrounded by a dense leukemic infiltrate. The areas of contrast enhancement, highly unusual for PML, coincided with the CLL infiltrate.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 14 , Issue 4 , November 1987 , pp. 600 - 602
Copyright
Copyright © Canadian Neurological Sciences Federation 1987

References

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