Hostname: page-component-788cddb947-jbkpb Total loading time: 0 Render date: 2024-10-18T23:12:52.648Z Has data issue: false hasContentIssue false
  • English
  • Français

Comparison of Counts of Neurons in the Locus Coeruleus Made From Serial Sections and From a Single Section at the Centre of the Nucleus

Published online by Cambridge University Press:  18 September 2015

C.Q. Mountjoy  and
W. Bondareff
C.Q. Mountjoy
Affiliation:
Department of Psychiatry, University of Cambridge Clinical School, and St. Andrew's Hospital, Northampton, England
W. Bondareff*
Affiliation:
Department of Psychiatry and Andrus Gerontology Centre, University of Southern California, Los Angeles, California
*
Department of Psychiatry, University of Southern California School of Medicine, Los Angeles, California, U.S.A.
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

This paper describes the comparability of counts in the locus coeruleus made from serial sections and those made from a single section at the point of greatest density of neurons. Samples of the locus coeruleus neuronal population derived from single section counts though not exactly comparable, are of comparable utility to those obtained from more laborious total neuronal counts. The simpler method was used to examine the hypothesis that there are subtypes of senile dementia of the Alzheimer type. Separation into two groups was achieved when independent variables of cortical neuronal counts and tangle estimates were used. This finding adds to the growing evidence that Alzheimer's disease of the senile type is not a unitary disorder.

Type
Cellular Clues to Pathogenesis
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 480 - 482
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

1.Vijayashankar, N and Brody, H. A quantitative study of the pigmented neurons in the nucleus locus ceruleus and subcoeruleus in man as related to aging. J Neuropath and Exper Neurol 1979; 38: 490–497.CrossRefGoogle Scholar
2.Forno, LS. The locus caeruleus in Alzheimer’s disease. J Neuropath Exper Neurol 1978; 37: 614.CrossRefGoogle Scholar
3.Tomlinson, BE, Irving, D, Blessed, G. Cell loss in the locus coeruleus in senile dementia of the Alzheimer type. J Neurol Sci 1981; 49: 419–428.CrossRefGoogle Scholar
4.Mann, DMA, Yates, PO, Hawkes, J. The noradrenergic system in Alzheimer and multi-infarct dementias. J Neurol Neurosurg Psychiatry 1982; 45: 113–119.CrossRefGoogle ScholarPubMed
5.Bondareff, W, Mountjoy, CQ, Roth, M. Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia. Neurology 1982; 32: 164–168.CrossRefGoogle ScholarPubMed
6.Iversen, LL, Rossor, MN, Reynolds, GPet al. Loss of pigmented dopamine-b-hydroxylase positive cells from locus coeruleus in senile dementia of Alzheimer’s type. Neurosci Letters 1983; 39: 95–100.CrossRefGoogle Scholar
7.Bondareff, W. Age and Alzheimer’s disease. Lancet 1983; 1: 1447.CrossRefGoogle Scholar
8.Rossor, MN, Iversen, LL, Reynolds, GP, et al. Neurochemical characteristics of early and late onset types of Alzheimer’s disease. Br Med J 288: 961–964.CrossRefGoogle Scholar
9.Mountjoy, CQ, Roth, M, Evans, NJR, et al. Cortical neuronal counts in normal elderly controls and demented patients. Neurobiol Aging. 1983; 4: 1–11.CrossRefGoogle ScholarPubMed
10.Bondareff, W, Mountjoy, CQ. Number of neurons in nucleus locus ceruleus in demented and non-demented patients: rapid estimation and correlated parameters. Neurobiol Aging 1986 (in press).CrossRefGoogle ScholarPubMed
11.Hubbard, BM, Anderson, JM. A quantitative study of cerebral atrophy in old age and senile dementia. J Neurol Sci 1981; 50: 135–145.CrossRefGoogle ScholarPubMed
12.Bondareff, W, Mountjoy, CQ, Roth, M, et al. Age and histopathological heterogeneity in Alzheimer’s Disease: evidence for subtypes. Arch Gen Psychiatry (in press).Google Scholar