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Amantadine for Gait Dysfunction in Pantothenate Kinase-Associated Neurodegeneration

  • Duha M. Al-Shorafat (a1) and Anthony E. Lang (a1)
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Copyright

Corresponding author

Correspondence to: Anthony E. Lang, Department of Neurology, Toronto Western Hospital, 399 Bathurst Street, MC 7-412, Toronto, Ontario, M5T 2S8, Canada. Email: Anthony.Lang@uhnresearch.ca

References

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1.Kurian, MA, Hayflick, SJ. Pantothenate kinase-associated neurodegeneration (PKAN) and PLA2G6-associated neurodegeneration (PLAN): review of two major neurodegeneration with brain iron accumulation (NBIA) phenotypes. Int Rev Neurobiol. 2013;110:49–71.
2.Hogarth, P, Kurian, MA, Gregory, A, et al. Consensus clinical management guideline for pantothenate kinase-associated neurodegeneration (PKAN). Mol Genet Metab. 2017;120(3):278–87. doi:10.1016/j.ymgme.2016.11.004
3.Rohani, M, Shahidi, G, Alavi, A, et al. Tremor-dominant pantothenate kinase associated neurodegeneration. Mov Disord Clin Pract. 2017;4(5):772–4.
4.Dooling, EC, Schoene, WC, Richardson, EP, , Jr. Hallervorden-Spatz syndrome. Arch Neurol. 1974;30(1):7083.
5.Chan, H, Kukkle, PL, Merello, M, Lim, S, Poon, Y, Moro, E. Parkinsonism and related disorders amantadine improves gait in PD patients with STN stimulation. Park Relat Disord. 2013;19(3):316–9.
6.Hiller, A, Murchison, C, Nichols, J, Quinn, J. The effects of amantadine on the progression of progressive supranuclear palsy (PSP) (P6.068). Neurology. 2018;90(15 Supplement):P6.068.
7.Kwon, K, Lee, HM, Kim, M, Kang, SH, Koh, S. Parkinsonism and related disorders long-lasting isolated freezing of gait with good response to methylphenidate: a patient with pantothenate kinase-associated neurodegeneration. Park Relat Disord. 2015;21(6):671–2.
8.Lyoo, CH, Prokisch, H, Meitinger, T, Lee, SY, Kim, DH, Lee, MS. Anticholinergic responsive gait freezing in a patient with pantotenate kinase-associated neurodegeneration. Mov Disord. 2008;23(2):283–4.

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Amantadine for Gait Dysfunction in Pantothenate Kinase-Associated Neurodegeneration

  • Duha M. Al-Shorafat (a1) and Anthony E. Lang (a1)

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