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Supplementation with wheat selenium induces a dose-dependent response in serum and urine of a Se-replete population

Published online by Cambridge University Press:  09 March 2007

Helle M. Meltzer ,
Gunnar Norheim ,
Elin BjØRge LØken  and
Halvor Holm
Helle M. Meltzer
Affiliation:
University of Oslo, Institute for Nutrition Research, School of Medicine, PO Box 1046 Blindern, 0316 Oslo 3, Norway
Gunnar Norheim
Affiliation:
Department of Pharmacology and Toxicology, Norwegian College of Veterinary Medicine / National Veterinary Institute, PO Box 8146 Dep, N-0033 Oslo 1, Norway
Elin BjØRge LØken
Affiliation:
University of Oslo, Institute for Nutrition Research, School of Medicine, PO Box 1046 Blindern, 0316 Oslo 3, Norway
Halvor Holm
Affiliation:
University of Oslo, Institute for Nutrition Research, School of Medicine, PO Box 1046 Blindern, 0316 Oslo 3, Norway
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Abstract

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In spite of a rather modest dietary intake of selenium (80 μg/10 MJ), Norwegian serum Se levels are among the highest in Europe. As part of an ongoing study of Se bioavailability, effects of different doses of wheat Se were investigated in eighteen healthy, Norwegian women. The participants were given Se-rich bread providing 100, 200 and 300 μg Se daily for 6 weeks. About 50% of the Se intake was excreted in the urine by week 6, compared with 67% before the intervention started. Serum Se increased by 20, 37 and 53 μg/I respectively, in the three groups (P < 0.001). The blood response and renal clearance results compare well with data obtained from less Se-replete populations, and support the hypothesis that selenomethionine from the diet is incorporated into a non-specific amino acid pool. Our study indicates that the intake of wheat Se is the main determinant of blood Se levels in Norway.

Keywords

SeleniumWheat seleniumBioavailability
Type
Supplementation with Selenium
Information
British Journal of Nutrition , Volume 67 , Issue 2 , March 1992 , pp. 287 - 294
Copyright
Copyright © The Nutrition Society 1992

References

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