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Serum 25-hydroxyvitamin D, calcium and parathyroid hormone levels in Native and European populations in Greenland

  • Stig Andersen (a1) (a2) (a3) (a4), Paneeraq Noahsen (a1) (a2), Karsten F. Rex (a1) (a2), Inuuteq Fleischer (a1) (a5), Nadja Albertsen (a1) (a4), Marit E. Jørgensen (a3) (a6), Louise K. Schæbel (a1) (a4) and Mogens B. Laursen (a5)...

Abstract

Ca homoeostasis is important to human health and tightly controlled by powerful hormonal mechanisms that display ethnic variation. Ethnic variations could occur also in Arctic populations where the traditional Inuit diet is low in Ca and sun exposure is limited. We aimed to assess factors important to parathyroid hormone (PTH) and Ca in serum in Arctic populations. We included Inuit and Caucasians aged 50–69 years living in the capital city in West or in rural East Greenland. Lifestyle factors were assessed by questionnaires. The intake of Inuit diet was assessed from a FFQ. 25-Hydroxyvitamin D (25OHD2 and 25OHD3) levels were measured in serum as was albumin, Ca and PTH. The participation rate was 95 %, with 101 Caucasians and 434 Inuit. Median serum 25OHD (99·7 % was 25OHD3) in Caucasians/Inuit was 42/64 nmol/l (25, 75 percentiles 25, 54/51, 81) (P<0·001). Total Ca in serum was 2·33/2·29 mmol/l (25, 75 percentiles 2·26, 2·38/2·21, 2·36) (P=0·01) and PTH was 2·7/2·2 pmol/l (25, 75 percentiles 2·2, 4·1/1·7, 2·7) (P<0·001). The 69/97 Caucasians/Inuit with serum 25OHD <50 nmol/l differed in PTH (P=0·001) that rose with lower 25OHD levels in Caucasians, whereas this was not the case in Inuit. Ethnic origin influenced PTH (β=0·27, P<0·001) and Ca (β=0·22, P<0·001) in multivariate linear regression models after adjustment for age, sex, BMI, smoking, alcohol and diet. In conclusion, ethnic origin influenced PTH, PTH response to low vitamin D levels and Ca levels in populations in Greenland. Recommendations are to evaluate mechanisms underlying the ethnic influence on Ca homoeostasis and to assess the impact of transition in dietary habits on Ca homoeostasis and skeletal health in Arctic populations.

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Corresponding author

* Corresponding author: S. Andersen, email stiga@dadlnet.dk

References

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1. Holick, MF (2007) Vitamin D deficiency. N Engl J Med 357, 266281.
2. Adams, JS & Hewison, M (2010) Update in vitamin D. J Clin Endocrinol Metab 95, 471478.
3. Hagenau, T, Vest, R, Gissel, TN, et al. (2009) Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis. Osteoporos Int 20, 133140.
4. El Hayek Fares, J & Weiler, HA (2016) Implications of the nutrition transition for vitamin D intake and status in Aboriginal groups in the Canadian Arctic. Nutr Rev 74, 571583.
5. Andersen, S, Jakobsen, A, Rex, HL, et al. (2013) Vitamin D in Greenland – dermal and dietary donations. Int J Circumpolar Health 72, 21225.
6. Rejnmark, L, Jørgensen, ME, Pedersen, MB, et al. (2004) Vitamin D insufficiency in Greenlanders on a westernized fare: ethnic differences in calcitropic hormones between Greenlanders and Danes. Calcif Tissue Int 74, 255263.
7. Andersen, S, Laurberg, P, Hvingel, B, et al. (2013) Vitamin D status in Greenland is influenced by diet and ethnicity: a population-based survey in an Arctic society in transition. Br J Nutr 109, 928935.
8. Keiver, KM, Draper, HH & Ronald, KJ (1988) Vitamin D metabolism in the hooded seal (Cystophora cristata). Nutr 118, 332341.
9. Lu, Z, Chen, TC, Zhang, A, et al. (2007) An evaluation of the vitamin D3 content in fish: is the vitamin D content adequate to satisfy the dietary requirement for vitamin D? J Steroid Biochem Mol Biol 103, 642644.
10. Kuhnlein, HV, Receveur, O, Soueida, R, et al. (2008) Unique patterns of dietary adequacy in three cultures of Canadian Arctic indigenous peoples. Public Health Nutr 11, 349360.
11. Andersen, S, Hvingel, B, Kleinschmidt, K, et al. (2005) Changes in iodine excretion in 50–69-y-old denizens of an Arctic society in transition and iodine excretion as a biomarker of the frequency of consumption of traditional Inuit foods. Am J Clin Nutr 81, 656663.
12. Andersen, S, Jakobsen, A & Laurberg, P (2013) Vitamin D status in North Greenland is influenced by diet and season: indicators of dermal 25-hydroxy vitamin D production north of the Arctic Circle. Br J Nutr 111, 5057.
13. Sharma, S, Hopping, BN, Roache, C, et al. (2013) Nutrient intakes, major food sources and dietary inadequacies of Inuit adults living in three remote communities in Nunavut, Canada. J Hum Nutr Diet 26, 578586.
14. Johnson, JS, Nobmann, ED, Asay, E, et al. (2009) Dietary intake of Alaska Native people in two regions and implications for health: the Alaska Native Dietary and Subsistence Food Assessment Project. Int J Circumplar Health 68, 109122.
15. Deutch, B, Dyerberg, J, Pedersen, HS, et al. (2007) Traditional and modern Greenlandic food – dietary composition, nutrients and contaminants. Sci Total Environ 384, 106109.
16. Jeppesen, BB & Harvald, B (1983) Serum calcium in Greenland Eskimos. Acta Med Scand 214, 99101.
17. Bringhurst, FR, Demay, MB & Kronenberg, HM (2016) Calcium and phosphate homeostasis. In Williams Textbook of Endocrinology, 13th ed. pp. 12541322 [S Melmed, KS Polonsky, PR Larsen and HM Kronenberg, editors]. Amsterdam: Elsevier.
18. Sorensen, VN, Wojtek, P, Pedersen, D, et al. (2015) An efficient case finding strategy to diagnose osteoporosis in a developing society with low treatment frequency. J Endocrinol Invest 38, 841847.
19. Meyer, A, Ladefoged, K, Poulsen, P, et al. (2008) Population-based survey of invasive bacterial diseases, Greenland, 1995–2004. Emerg Infect Dis 14, 7679.
20. Kjaergaard, M, Andersen, S, Holten, M, et al. (2009) Low occurrence of ischemic heart disease among Inuit around 1963 suggested from ECG among 1851 East Greenland Inuit. Atherosclerosis 203, 599603.
21. Jorgensen, ME, Bjerregaard, P, Kjaergaard, JJ, et al. (2008) High prevalence of markers of coronary heart disease among Greenland Inuit. Atherosclerosis 196, 772778.
22. Petersen, P & Christensen, LB (2006) Cariesforekomsten i tidsperspektiv hos børn og unge i Grønland – udfordringer for forebyggelse og sundhedsfremme (Caries ocurrence among children and adolscent in Greenland – challenges in prevention and health promotion). Tandlaegebladet (Danish Dental Journal) 110, 486493.
23. Pars, T (2000) Forbruget af traditionelle grønlandske fødevarer i Vestgrønland. (Contemporary use of traditional foods among Greenlandic Inuit). Doctoral dissertation, University of Copenhagen (in Danish).
24. Andersen, S, Hvingel, B & Laurberg, P (2002) Iodine content of traditional Greenlandic food items and tap water in East and West Greenland. Int J Circumpolar Health 6, 332340.
25. Hojskov, CS, Heickendorff, L & Moller, HJ (2010) High-throughput liquid-liquid extraction and LCMSMS assay for determination of circulating 25(OH) vitamin D3 and D2 in the routine clinical laboratory. Clin Chim Acta 411, 114116.
26. Chen, LZ, Easteal, S, Board, PG, et al. (1990) Albumin-vitamin D-binding protein haplotypes in Asian-Pacific populations. Hum Genet 85, 8997.
27. Jones, KS, Schoenmakers, I, Assar, S, et al. (2014) 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by vitamin D binding protein concentration and genotype. J Clin Endocrinol Metab 99, 33733381.
28. Jones, KS, Assar, S, Vanderschueren, D, et al. (2015) Predictors of 25(OH)D half-life and plasma 25(OH)D concentration in The Gambia and the UK. Osteoporos Int 26, 11371146.
29. Fumagalli, M, Moltke, I, Grarup, N, et al. (2015) Greenlandic Inuit show genetic signatures of diet and climate adaptation. Science 349, 13431347.
30. Andersen, S, Rex, KF, Noahsen, P, et al. (2013) Raised BMI cut-off for overweight in Greenland Inuit – a review. Int J Circumpolar Health 72, 21086.
31. Andersen, S, Mulvad, G, Pedersen, HS, et al. (2004) Gender diversity in developing overweight over 35 years of westernization in an Inuit hunter cohort and ethno-specific body mass index for evaluation of body-weight abnormalities. Eur J Endocrinol 151, 735740.
32. Noahsen, P & Andersen, S (2013) Ethnicity influences BMI as evaluated from reported serum lipid values in Inuit and non-Inuit: raised upper limit of BMI in Inuit? Ethnicity & Disease 23, 7782.
33. Bjerregaard, P, Jørgensen, M & Borch-Johnsen, K (2007) Cardiovascular risk amongst migrant and non-migrant Greenland Inuit in a gender perspective. Scand J Public Health 35, 380386.
34. Jakobsen, A, Laurberg, P, Vestergaard, P, et al. (2013) Clinical risk factors for osteoporosis are common among elderly people in Nuuk, Greenland. Int J Circumpolar Health 72, 19596.
35. Andersen, S, Boeskov, E & Laurberg, P (2005) Ethnic differences in bone mineral density between Inuit and Caucasians in North Greenland are caused by differences in body size. J Clin Densitom 8, 409414.
36. Nielsen, NO, Bjerregaard, P, Rønn, PF, et al. (2016) Associations between vitamin D status and type 2 diabetes measures among Inuit in Greenland may be affected by other factors. PLOS ONE 11, e0152763.
37. Kuhnlein, HV, Receveur, O, Soueida, R, et al. (2004) Arctic indigenous peoples experience the nutrition transition with changing dietary patterns and obesity. J Nutr 124, 14471453.
38. Redmond, J, Jarjou, LMA, Zhou, B, et al. (2014) Ethnic differences in calcium, phosphate and bone metabolism. Proc Nutr Soc 73, 340351.
39. Andersen, S, Dehnfeld, M & Laurberg, P (2015) Ethnicity is important for creatinine excretion among Inuit and Caucasians in Greenland. Scand J Clin Lab Invest 75, 4450.

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Serum 25-hydroxyvitamin D, calcium and parathyroid hormone levels in Native and European populations in Greenland

  • Stig Andersen (a1) (a2) (a3) (a4), Paneeraq Noahsen (a1) (a2), Karsten F. Rex (a1) (a2), Inuuteq Fleischer (a1) (a5), Nadja Albertsen (a1) (a4), Marit E. Jørgensen (a3) (a6), Louise K. Schæbel (a1) (a4) and Mogens B. Laursen (a5)...

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