1Hocquette, JF, Tesseraud, S, Cassar-Malek, I, et al. (2007) Responses to nutrients in farm animals: implications for production and quality. Animal 1, 1297–1313.
2Obled, C, Papet, I & Breuille, D (2004) . In Metabolic and Therapeutic Aspects of Amino Acids in Clinical Nutrition, 2nd ed., pp. 667–687 [Cynober, LA, editor]. Boca Raton, FL: CRC Press LLC.
3Le Floc'h, N, Melchior, D & Obled, C (2004) Modifications of protein and amino acid metabolism during inflammation and immune system activation. Livest Prod Sci 87, 37–45.
4Soeters, PB, van de Poll, MC, van Gemert, WG, et al. (2004) Amino acid adequacy in pathophysiological states. J Nutr 134, 1575S–1582S.
5van de Poll, MC, Dejong, CH & Soeters, PB (2006) Adequate range for sulfur-containing amino acids and biomarkers for their excess: lessons from enteral and parenteral nutrition. J Nutr 136, 1694S–1700S.
6Stipanuk, MH, Dominy, JE Jr, Lee, JI, et al. (2006) Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr 136, 1652S–1659S.
7Garlick, PJ (2006) Toxicity of methionine in humans. J Nutr 136, 1722S–1725S.
8Métayer, S, Seiliez, I, Collin, A, et al. (2008) Mechanisms through which sulfur amino acids control protein metabolism and oxidative status. J Nutr Biochem 19, 207–215.
9Wu, G, Fang, YZ, Yang, S, et al. (2004) Glutathione metabolism and its implications for health. J Nutr 134, 489–492.
10Moskovitz, J, Rahman, MA, Strassman, J, et al. (1995) Escherichia coli peptide methionine sulfoxide reductase gene: regulation of expression and role in protecting against oxidative damage. J Bacteriol 177, 502–507.
11Levine, RL, Mosoni, L, Berlett, BS, et al. (1996) Methionine residues as endogenous antioxidants in proteins. Proc Natl Acad Sci U S A 93, 15036–15040.
12Mariotti, F, Simbelie, KL, Makarios-Lahham, L, et al. (2004) Acute ingestion of dietary proteins improves post-exercise liver glutathione in rats in a dose-dependent relationship with their cysteine content. J Nutr 134, 128–131.
13Diniz, YS, Rocha, KK, Souza, GA, et al. (2006) Effects of N-acetylcysteine on sucrose-rich diet-induced hyperglycaemia, dyslipidemia and oxidative stress in rats. Eur J Pharmacol 543, 151–157.
14Dröge, W (2006) Redox regulation in anabolic and catabolic processes. Curr Opin Clin Nutr Metab Care 9, 190–195.
15Blouet, C, Mariotti, F, Azzout-Marniche, D, et al. (2007) Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance. Free Radic Biol Med 42, 1089–1097.
16Blouet, C, Mariotti, F, Mikogami, T, et al. (2007) Meal cysteine improves postprandial glucose control in rats fed a high-sucrose meal. J Nutr Biochem 18, 519–524.
17Mariotti, F, Hermier, D, Sarrat, C, et al. (2008) Rapeseed protein inhibits the initiation of insulin resistance by a high-saturated fat, high-sucrose diet in rats. Br J Nutr 100, 984–991.
18Tsakiris, S, Parthimos, T, Parthimos, N, et al. (2006) The beneficial effect of l-cysteine supplementation on DNA oxidation induced by forced training. Pharmacol Res 53, 386–390.
19Parthimos, T, Tsopanakis, C, Angelogianni, P, et al. (2007) l-Cysteine supplementation prevents exercise-induced alterations in human erythrocyte membrane acetylcholinesterase and Na+,K+-ATPase activities. Clin Chem Lab Med 45, 67–72.
20Schulpis, KH, Reclos, GJ, Parthimos, T, et al. (2006) l-Cysteine supplementation protects the erythrocyte glucose-6-phosphate dehydrogenase activity from reduction induced by forced training. Clin Biochem 39, 1002–1006.
21Lands, LC, Grey, VL & Smountas, AA (1999) Effect of supplementation with a cysteine donor on muscular performance. J Appl Physiol 87, 1381–1385.
22Jonas, CR, Ziegler, TR, Gu, LH, et al. (2002) Extracellular thiol/disulfide redox state affects proliferation rate in a human colon carcinoma (Caco2) cell line. Free Radic Biol Med 33, 1499–1506.
23Nkabyo, YS, Go, YM, Ziegler, TR, et al. (2005) Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor signaling. Am J Physiol Gastrointest Liver Physiol 289, G70–G78.
24Go, YM & Jones, DP (2005) Intracellular proatherogenic events and cell adhesion modulated by extracellular thiol/disulfide redox state. Circulation 111, 2973–2980.
25Jiang, S, Moriarty-Craige, SE, Orr, M, et al. (2005) Oxidant-induced apoptosis in human retinal pigment epithelial cells: dependence on extracellular redox state. Invest Ophthalmol Vis Sci 46, 1054–1061.
26Banjac, A, Perisic, T, Sato, H, et al. (2008) The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death. Oncogene 27, 1618–1628.
27Go, YM & Jones, DP (2008) Redox compartmentalization in eukaryotic cells. Biochim Biophys Acta 1780, 1273–1290.
28Blanco, RA, Ziegler, TR, Carlson, BA, et al. (2007) Diurnal variation in glutathione and cysteine redox states in human plasma. Am J Clin Nutr 86, 1016–1023.
29Nkabyo, YS, Gu, LH, Jones, DP, et al. (2006) Thiol/disulfide redox status is oxidized in plasma and small intestinal and colonic mucosa of rats with inadequate sulfur amino acid intake. J Nutr 136, 1242–1248.
30Sanz, A, Caro, P, Ayala, V, et al. (2006) Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins. FASEB J 20, 1064–1073.
31Caro, P, Gómez, J, López-Torres, M, et al. (2008) Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver. Biogerontology 9, 183–196.
32López-Torres, M & Barja, G (2008) Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction. Possible implications for humans. Biochim Biophys Acta 1780, 1337–1347.
33Stipanuk, MH (2004) Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr 24, 539–577.
34Abe, K & Kimura, H (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16, 1066–1071.
35Eto, K, Asada, T, Arima, K, et al. (2002) Brain hydrogen sulfide is severely decreased in Alzheimer's disease. Biochem Biophys Res Commun 293, 1485–1488.
36Han, Y, Qin, J, Chang, X, et al. (2005) Hydrogen sulfide may improve the hippocampal damage induced by recurrent febrile seizures in rats. Biochem Biophys Res Commun 327, 431–436.
37Kimura, H (2000) Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor. Biochem Biophys Res Commun 267, 129–133.
38Kimura, Y & Kimura, H (2004) Hydrogen sulfide protects neurons from oxidative stress. FASEB J 18, 1165–1167.
39Zhao, W, Zhang, J, Lu, Y, et al. (2001) The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener. EMBO J 20, 6008–6016.
40Tang, G, Wu, L, Liang, W, et al. (2005) Direct stimulation of KATP channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells. Mol Pharmacol 68, 1757–1764.
41Yang, W, Yang, G, Jia, X, et al. (2005) Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms. J Physiol 569, 519–531.
42Zhao, W & Wang, R (2002) H2S-induced vasorelaxation and underlying cellular and molecular mechanisms. Am J Physiol Heart Circ Physiol 283, H474–H480.
43Cheng, Y, Ndisang, JF, Tang, G, et al. (2004) Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats. Am J Physiol Heart Circ Physiol 287, H2316–H2323.
44Hosoki, R, Matsuki, N & Kimura, H (1997) The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun 237, 527–531.
45Kaneko, Y, Kimura, Y, Kimura, H, et al. (2006) l-Cysteine inhibits insulin release from the pancreatic β-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter. Diabetes 55, 1391–1397.
46Hamadeh, MJ & Hoffer, LJ (2001) Use of sulfate production as a measure of short-term sulfur amino acid catabolism in humans. Am J Physiol Endocrinol Metab 280, E857–E866.
47Hamadeh, MJ & Hoffer, LJ (2003) Effect of protein restriction on sulfur amino acid catabolism in insulin-dependent diabetes mellitus. Am J Physiol Endocrinol Metab 284, E382–E389.
48Hoffer, LJ, Hamadeh, MJ, Robitaille, L, et al. (2005) Human sulfate kinetics. Am J Physiol Regul Integr Comp Physiol 289, R1372–R1380.
49Gregus, Z, Kim, HJ, Madhu, C, et al. (1994) Sulfation of acetaminophen and acetaminophen-induced alterations in sulfate and 3′-phosphoadenosine 5′-phosphosulfate homeostasis in rats with deficient dietary intake of sulfur. Drug Metab Dispos 22, 725–730.
50Hu, JF, Zhao, XH, Parpia, B, et al. (1993) Dietary intakes and urinary excretion of calcium and acids: a cross-sectional study of women in China. Am J Clin Nutr 58, 398–406.
51Whiting, SJ & Draper, HH (1980) The role of sulfate in the calciuria of high protein diets in adult rats. J Nutr 110, 212–222.
52Thorpe, M, Mojtahedi, MC, Chapman-Novakofski, K, et al. (2008) A positive association of lumbar spine bone mineral density with dietary protein is suppressed by a negative association with protein sulfur. J Nutr 138, 80–85.
53Jefferson, LS & Kimball, SR (2001) Amino acid regulation of gene expression. J Nutr 131, 2460S–2466S.
54Kilberg, MS, Pan, YX, Chen, H, et al. (2005) Nutritional control of gene expression: how mammalian cells respond to amino acid limitation. Annu Rev Nutr 25, 59–85.
55Jousse, C, Averous, J, Bruhat, A, et al. (2004) Amino acids as regulators of gene expression: molecular mechanisms. Biochem Biophys Res Commun 313, 447–452.
56Shigemitsu, K, Tsujishita, Y, Miyake, H, et al. (1999) Structural requirement of leucine for activation of p70 S6 kinase. FEBS Lett 447, 303–306.
57Stubbs, AK, Wheelhouse, NM, Lomax, MA, et al. (2002) Nutrient–hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression. J Endocrinol 174, 335–341.
58Tesseraud, S, Bigot, K & Taouis, M (2003) Amino acid availability regulates S6K1 and protein synthesis in avian insulin-insensitive QM7 myoblasts. FEBS Lett 540, 176–180.
59Kimball, SR & Jefferson, LS (2005) Role of amino acids in the translational control of protein synthesis in mammals. Semin Cell Dev Biol 16, 21–27.
60Wek, RC, Jiang, HY & Anthony, TG (2006) Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans 34, 7–11.
61Tremblay, F, Lavigne, C, Jacques, H, et al. (2007) Role of dietary proteins and amino acids in the pathogenesis of insulin resistance. Annu Rev Nutr 27, 293–310.
62Averous, J, Bruhat, A, Jousse, C, et al. (2004) Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. J Biol Chem 279, 5288–5297.
63Jousse, C, Bruhat, A, Ferrara, M, et al. (2000) Evidence for multiple signaling pathways in the regulation of gene expression by amino acids in human cell lines. J Nutr 130, 1555–1560.
64Bruhat, A, Jousse, C, Wang, XZ, et al. (1997) Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels. J Biol Chem 272, 17588–17593.
65Lee, JI, Dominy, JE Jr, Sikalidis, AK, et al. (2008) HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway. Physiol Genomics 33, 218–229.
66Roybal, CN, Yang, S, Sun, CW, et al. (2004) Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. J Biol Chem 279, 14844–14852.
67Tremblay, F & Marette, A (2001) Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276, 38052–38060.
68Hinault, C, Van Obberghen, E & Mothe-Satney, I (2006) Role of amino acids in insulin signaling in adipocytes and their potential to decrease insulin resistance of adipose tissue. J Nutr Biochem 17, 374–378.
69Tesseraud, S, Métayer-Coustard, S, Boussaid, S, et al. (2007) Insulin and amino acid availability regulate atrogin-1 in avian QT6 cells. Biochem Biophys Res Commun 357, 181–186.
70Mihm, S, Ennen, J, Pessara, U, et al. (1991) Inhibition of HIV-1 replication and NF-κB activity by cysteine and cysteine derivatives. AIDS 5, 497–503.
71Shibanuma, M, Kuroki, T & Nose, K (1994) Inhibition by N-acetyl-l-cysteine of interleukin-6 mRNA induction and activation of NFκB by tumor necrosis factor α in a mouse fibroblastic cell line, Balb/3T3. FEBS Lett 353, 62–66.
72Paterson, RL, Galley, HF & Webster, NR (2003) The effect of N-acetylcysteine on nuclear factor-κB activation, interleukin-6, interleukin-8, and intercellular adhesion molecule-1 expression in patients with sepsis. Crit Care Med 31, 2574–2578.
73Lee, KS, Kim, SR, Park, HS, et al. (2007) A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-κB and hypoxia-inducible factor-1α. Exp Mol Med 39, 756–768.
74Barnes, PJ & Karin, M (1997) Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336, 1066–1071.
75Chen, F, Castranova, V, Shi, X, et al. (1999) New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 45, 7–17.
76Grimble, RF (2006) The effects of sulfur amino acid intake on immune function in humans. J Nutr 136, Suppl. 6, 1660S–1665S.
77Oda, H (2006) Functions of sulfur-containing amino acids in lipid metabolism. J Nutr 136, Suppl. 6, 1666S–1669S.
78Troen, AM, Lutgens, E, Smith, DE, et al. (2003) The atherogenic effect of excess methionine intake. Proc Natl Acad Sci U S A 100, 15089–15094.
79Gerhard, GT & Duell, PB (1999) Homocysteine and atherosclerosis. Curr Opin Lipidol 10, 417–428.
80Zhou, J, Werstuck, GH, Lhoták, S, et al. (2008) Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice. FASEB J 22, 2569–2578.
81Liu, C, Wang, Q, Guo, H, et al. (2008) Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine. J Nutr 138, 311–315.
82Jamison, RL, Hartigan, P, Kaufman, JS, et al. (2007) Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial. JAMA 298, 1163–1170.
83Albert, CM, Cook, NR, Gaziano, JM, et al. (2008) Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA 299, 2027–2036.
84Egger, G, Liang, G, Aparicio, A, et al. (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature 429, 457–463.
85Ulrey, CL, Liu, L, Andrews, LG, et al. (2005) The impact of metabolism on DNA methylation. Hum Mol Genet 14, R139–R147.
86Grønbaek, K, Hother, C & Jones, PA (2007) Epigenetic changes in cancer. APMIS 115, 1039–1059.
87Waterland, RA & Michels, KB (2007) Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr 27, 363–388.
88Nafee, TM, Farrell, WE, Carroll, WD, et al. (2008) Epigenetic control of fetal gene expression. BJOG 115, 158–168.
89Waterland, RA (2006) Assessing the effects of high methionine intake on DNA methylation. J Nutr 136, Suppl. 6, 1706S–1710S.
90Brosnan, JT, da Silva, R & Brosnan, ME (2007) Amino acids and the regulation of methyl balance in humans. Curr Opin Clin Nutr Metab Care 10, 52–57.
91Williams, KT & Schalinske, KL (2007) New insights into the regulation of methyl group and homocysteine metabolism. J Nutr 137, 311–314.
92Dunlevy, LP, Burren, KA, Chitty, LS, et al. (2006) Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos. FEBS Lett 580, 2803–2807.
93Reed, MC, Nijhout, HF, Sparks, R, et al. (2004) A mathematical model of the methionine cycle. J Theor Biol 226, 33–43.
94Reed, MC, Nijhout, HF, Neuhouser, ML, et al. (2006) A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J Nutr 136, 2653–2661.
95Pogribny, IP, Ross, SA, Wise, C, et al. (2006) Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency.Mutat Res 593, 80–87.
96Pogribny, IP, Karpf, AR, James, SR, et al. (2008) Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet. Brain Res 1237, 25–34.
97Lu, X, Freund, JN, Muller, M, et al. (2008) Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors. Biochimie 90, 697–704.
98Rees, WD, Wilson, FA & Maloney, CA (2006) Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet. J Nutr 136, Suppl. 6, 1701S–1705S.
99Waterland, RA, Dolinoy, DC, Lin, JR, et al. (2006) Maternal methyl supplements increase offspring DNA methylation at Axin Fused. Genesis 44, 401–406.
100Rees, WD (2002) Manipulating the sulfur amino acid content of the early diet and its implications for long-term health. Proc Nutr Soc 61, 71–77.
101Sinclair, KD, Allegrucci, C, Singh, R, et al. (2007) DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A 104, 19351–19356.