Skip to main content Accessibility help
×
Home

A preclinical study to model taurine pharmokinetics in the undernourished rat

  • Ana Catalán-Latorre (a1) (a2), Amparo Nácher (a1) (a2), Virginia Merino (a1) (a2), Octavio Díez (a1) (a2) and Matilde Merino Sanjuán (a1) (a2)...

Abstract

Malnutrition is a common feature of chronic and acute diseases, often associated with a poor prognosis, including worsening of clinical outcome, owing, among other factors, to dysfunction of the most internal organs and systems affecting the absorption, metabolism and elimination of drugs and nutrients. Taurine is involved in numerous biological processes and is required in increased amounts in response to pathological conditions. The aim of this study was to describe the behaviour of taurine in well-nourished (WN) rats and to analyse the influence of protein–energy undernutrition on the pharmacokinetic (PK) parameters of taurine, using a PK model. Wistar rats were randomly distributed into two groups, WN and undernourished (UN), and taurine was administered intravenously or orally at different doses: 1, 10 and 100 mg. Population pharmacokinetic modelling of plasma levels was performed using the NONMEM 7.2 program. Several distribution and absorption models were explored in combination with dose and/or time covariate effects. Covariates such as nutritional status, serum albumin, body weight and score of undernutrition were used. A two-compartment population pharmacokinetic model with zero-order endogenous formation, passive absorption, first-order kinetics distribution and non-linear elimination with parallel Michaelis–Menten excretion and reabsorption processes best described taurine pharmacokinetics. Undernutrition acted as a covariate reducing the V max of the active elimination process. Data analysis showed linear absorption and distribution, and non-linear elimination processes for taurine. Elimination of taurine was reduced in UN animals, suggesting that the reabsorption process via the secretion transporter was modified in that group.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      A preclinical study to model taurine pharmokinetics in the undernourished rat
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      A preclinical study to model taurine pharmokinetics in the undernourished rat
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      A preclinical study to model taurine pharmokinetics in the undernourished rat
      Available formats
      ×

Copyright

Corresponding author

* Corresponding author: M. Merino Sanjuán, email matilde.merino@uv.es

References

Hide All
1. Oshikoya, KA, Sammons, HM & Choonara, I (2010) A systematic review of pharmacokinetics studies in children with protein–energy malnutrition. Eur J Clin Pharmacol 66, 10251035.
2. da Silva Fink, J, Daniel de Mello, P & Daniel de Mello, E (2015) Subjective global assessment of nutritional status – a systematic review of the literature. Clin Nutr 34, 785792.
3. Correia, MI & Waitzberg, DL (2003) The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis. Clin Nutr 22, 235239.
4. Barker, LA, Gout, BS & Crowe, TC (2011) Hospital malnutrition: prevalence, identification and impact on patients and the healthcare system. Int J Environ Res Public Health 8, 514527.
5. Lim, SL, Lee, CJ & Chan, YH (2014) Prognostic validity of 3-Minute Nutrition Screening (3-MinNS) in predicting length of hospital stay, readmission, cost of hospitalisation and mortality: a cohort study. Asia Pac J Clin Nutr 23, 560566.
6. Chesney, RW, Han, X & Patters, AB (2010) Taurine and the renal system. J Biomed Sci 17, Suppl. 1, 14.
7. Lazzerini, M & Tickell, D (2011) Antibiotics in severely malnourished children: systematic review of efficacy, safety and pharmacokinetics. Bull World Health Organ 89, 594607.
8. Prado, CM, Maia, YL, Ormsbee, M, et al. (2013) Assessment of nutritional status in cancer--the relationship between body composition and pharmacokinetics. Anticancer Agents Med Chem 13, 11971203.
9. Lykke, M, Hother, AL, Hansen, CF, et al. (2013) Malnutrition induces gut atrophy and increases hepatic fat infiltration: studies in a pig model of childhood malnutrition. Am J Transl Res 5, 543554.
10. Sved, DW, Godsey, JL, Ledyard, SL, et al. (2007) Absorption, tissue distribution, metabolism and elimination of taurine given orally to rats. Amino Acids 32, 459466.
11. Chiarla, C, Giovannini, I & Siegel, JH (2003) Co-variation of plasma sodium, taurine and other amino acid levels in critical illness. Amino Acids 24, 8993.
12. Li, XW, Gao, HY & Liu, J (2017) The role of taurine in improving neural stem cells proliferation and differentiation. Nutr Neurosci 20, 409415.
13. Adedara, IA, Ojuade, TJ, Olabiyi, BF, et al. (2017) Taurine ameliorates renal oxidative damage and thyroid dysfunction in rats chronically exposed to fluoride. Biol Trace Elem Res 175, 388395.
14. Oja, SS & Saransaari, P (2013) Taurine and epilepsy. Epilepsy Res 104, 187194.
15. Sukhotnik, I, Aranovich, I, Ben Shahar, Y, et al. (2016) Effect of taurine on intestinal recovery following intestinal ischemia-reperfusion injury in a rat. Pediatr Surg Int 32, 161168.
16. Murakami, S (2015) Role of taurine in the pathogenesis of obesity. Mol Nutr Food Res 59, 13531363.
17. Murakami, S, Fujita, M, Nakamura, M, et al. (2016) Taurine ameliorates cholesterol metabolism by stimulating bile acid production in high-cholesterol-fed rats. Clin Exp Pharmacol Physiol 43, 372378.
18. Ito, T, Yoshikawa, N, Ito, H, et al. (2015) Impact of taurine depletion on glucose control and insulin secretion in mice. J Pharmacol Sci 129, 5964.
19. Rosca, AE, Stoian, I, Badiu, C, et al. (2016) Impact of chronic administration of anabolic androgenic steroids and taurine on blood pressure in rats. Braz J Med Biol Res 49, e5116.
20. Yang, YJ, Han, YY, Chen, K, et al. (2015) TonEBP modulates the protective effect of taurine in ischemia-induced cytotoxicity in cardiomyocytes. Cell Death Dis 6, e2025.
21. Abdel-Moneim, AM, Al-Kahtani, MA, El-Kersh, MA, et al. (2015) Free radical-scavenging, anti-inflammatory/anti-fibrotic and hepatoprotective actions of taurine and silymarin against CCl4 Induced rat liver damage. PLOS ONE 10, e0144509.
22. Ananchaipatana-Auitragoon, P, Ananchaipatana-Auitragoon, Y, Siripornpanich, V, et al. (2015) Protective role of taurine in developing offspring affected by maternal alcohol consumption. EXCLI J 14, 660671.
23. Xu, S, He, M, Zhong, M, et al. (2015) The neuroprotective effects of taurine against nickel by reducing oxidative stress and maintaining mitochondrial function in cortical neurons. Neurosci Lett 590C, 5257.
24. Das, J, Ghosh, J, Manna, P, et al. (2010) Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res 44, 340355.
25. Acharya, M & Lau-Cam, CA (2013) Comparative evaluation of the effects of taurine and thiotaurine on alterations of the cellular redox status and activities of antioxidant and glutathione-related enzymes by acetaminophen in the rat. Adv Exp Med Biol 776, 199215.
26. Rakotoambinina, B, Marks, L, Badran, AM, et al. (2004) Taurine kinetics assessed using [1,2-13C2]taurine in healthy adult humans. Am J Physiol Endocrinol Metab 287, E255E262.
27. Ghandforoush-Sattari, M, Mashayekhi, S, Krishna, CV, et al. (2010) Pharmacokinetics of oral taurine in healthy volunteers. J Amino Acids 2010, 346237.
28. Batista, TM, da Silva, PM, Amaral, AG, et al. (2013) Taurine supplementation restores insulin secretion and reduces ER stress markers in protein-malnourished mice. Adv Exp Med Biol 776, 129139.
29. Omran, ML & Morley, JE (2000) Assessment of protein energy malnutrition in older persons, Part II: Laboratory evaluation. Nutrition 16, 131140.
30. Teerlink, TVLPAM & Houdijk, A (1994) Plasma amino acids determined by liquid chromatography whitin 17 minutes. ClinChem 40/2, 245249.
31. Karnes, HTMC (1993) Precision, accuracy, and data acceptance criteria in biopharmaceutical analysis. Pharm Res 10, 14201426.
32. Beal, SL & Sheiner, LB (1989) NONMEM User’s Guides, NONMEM. Project Group. San Francisco, CA: University of California.
33. Karlsson, M & Holford, N (2008) A tutorial on visual predictive checks. Abstr 1434. https://www.page-meeting.org/?abstract=1434 (accessed June 2017).
34. Merino-Sanjuan, M, Catalan-Latorre, A, Nacher, A, et al. (2011) Animal model of undernutrition for the evaluation of drug pharmacokinetics. Nutr Hosp 26, 12961304.
35. Campos Moreno, E, Merino Sanjuan, M, Merino, V, et al. (2007) Population modelling to describe pharmacokinetics of amiodarone in rats: relevance of plasma protein and tissue depot binding. Eur J Pharm Sci 30, 190197.
36. Winter, TA, O’Keefe, SJ, Callanan, M, et al. (2007) Effect of severe undernutrition and subsequent refeeding on gut mucosal protein fractional synthesis in human subjects. Nutrition 23, 2935.
37. Saunders, J & Smith, T (2010) Malnutrition: causes and consequences. Clin Med 10, 624627.
38. Miralles-Arnau, S, Nacher, A, Jimenez, A, et al. (2011) Impact of nutritional status on the oral bioavailability of leucine administered to rats as part of a standard enteral diet. Clin Nutr 30, 517523.
39. Han, X, Patters, AB, Jones, DP, et al. (2006) The taurine transporter: mechanisms of regulation. Acta Physiol (Oxf) 187, 6173.
40. Sung, MJ & Chang, KJ (2009) Dietary taurine and nutrients intake and anthropometric and body composition data by abdominal obesity in Korean male college students. Adv Exp Med Biol 643, 429435.
41. Broer, S (2008) Amino acid transport across mammalian intestinal and renal epithelia. Physiol Rev 88, 249286.
42. Moll-Navarro, MJ, Merino, M, Casabo, VG, et al. (1996) Interaction of taurine on baclofen intestinal absorption: a nonlinear mathematical treatment using differential equations to describe kinetic inhibition models. J Pharm Sci 8, 12481254.
43. Warskulat, U, Heller-Stilb, B, Oermann, E, et al. (2007) Phenotype of the taurine transporter knockout mouse. Methods Enzymol 428, 439458.
44. Nestlé Health Science (2015) Product composition. https://www.nestlehealthscience.us/products/isosource%C2%AE-1-5-cal (accessed June 2017).
45. Abbott Nutrition (2010) Abbott nutritional online brochure. http://abbottnutrition.com.au/portals/0/img/all%20pages%20R1.pdf (accessed June 2017).

Keywords

A preclinical study to model taurine pharmokinetics in the undernourished rat

  • Ana Catalán-Latorre (a1) (a2), Amparo Nácher (a1) (a2), Virginia Merino (a1) (a2), Octavio Díez (a1) (a2) and Matilde Merino Sanjuán (a1) (a2)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed