1Prahl, A, Guptill, L, Glickman, NW, et al. (2007) Time trends and risk factors for diabetes mellitus in cats presented to veterinary hospitals. J Feline Med Surg 9, 351–358.
2Rand, JS, Fleeman, LM, Farrow, HA, et al. (2004) Canine and feline diabetes mellitus: nature or nurture? J Nutr 134, 2072S–2080S.
3Roberfroid, MB & Delzenne, NM (1998) Dietary fructans. Annu Rev Nutr 18, 117–143.
4Blaxter, AC, Cripps, PJ & Gruffydd-Jones, TJ (1990) Dietary fibre and postprandial hyperglycemia in normal and diabetic dogs. J Small Anim Pract 31, 229–233.
5Nelson, RW (1989) The role of fibre in managing diabetes mellitus. Vet Med 84, 1156–1160.
6Nelson, RW (1992) Dietary management of diabetes mellitus. J Small Anim Pract 33, 213–217.
7Delarue, J & Magnan, C (2007) Free fatty acids and insulin resistance. Curr Opin Clin Nutr Metab Care 10, 142–148.
8Diez, M, Hornick, J-L, Baldwin, P, et al. (1997) Influence of a blend of fructo-oligosaccharides and sugar beet fibre on nutrients digestibility and plasma metabolite concentrations in healthy beagle dogs. Am J Vet Res 58, 1238–1242.
9Diez, M, Hornick, J-L, Baldwin, P, et al. (1998) Influence of sugar-beet fibre, guar gum and inulin on nutrient digestibility, water consumption and plasma metabolites in healthy beagle dogs. Res Vet Sci 64, 91–96.
10Massimino, SP, McBurney, MI, Field, CJ, et al. (1998) Fermentable dietary fibre increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs. J Nutr 128, 1786–1793.
11Stirckling, J, Harmon, D, Gross, K, et al. (2000) Evaluation of oligosaccharide addition to dog diets: influences on nutrient digestion and microbial populations. Anim Feed Technol 86, 205–219.
12Hesta, M, Debraekeleer, J, Janssens, GPJ, et al. (2001) The effect of a commercial high fibre diet and an iso-malto-oligosaccharide supplemented diet on postprandial glucose concentrations in dogs. J Anim Physiol Anim Nutr 85, 217–221.
13Bremer, J (1983) Carnitine – metabolism and functions. Physiol Rev 63, 1420–1480.
14Appleton, DJ, Rand, JS & Sunvold, GD (2000) Plasma leptin concentrations in cats: reference range, effects of weight gain and relationship with adiposity as measured by dual energy X-ray absorptiometry. J Feline Med Surg 2, 191–199.
15Appleton, DJ, Rand, JS & Sunvold, GD (2002) Plasma leptin concentrations are independently associated with insulin resistance in lean and overweight cats. J Feline Med Surg 4, 83–93.
16Ferguson, DC, Caffall, Z & Hoenig, M (2007) Obesity increases free thyroxine proportionally to nonesterified fatty acid concentrations in adult neutered female cats. J Endocrinol 194, 267–273.
17National Research Council (2006) . In Nutrient Requirements of Dogs and Cats, pp. 28–48. Washington, DC: The National Academies Press.
18Scarlet, JM, Donoghue, S, Saidla, J, et al. (1994) Overweight cats: prevalence and risk factors. Int J Obes 18, Suppl. 1, S22–S28.
19Hoenig, M, Wilkins, C, Holson, JC, et al. (2003) Effects of obesity on lipid profiles in neutered male and female cats. Am J Vet Res 64, 299–303.
20Appleton, DJ, Rand, JS, Priest, J, et al. (2001) Determination of reference values for glucose tolerance, insulin tolerance, and insulin sensitivity tests in clinically normal cats. Am J Vet Res 62, 630–636.
21Martin, GJW & Rand, JS (1999) Evaluation of a polyurethane jugular catheter in cats placed using a modified Seldinger technique. Aust Vet J 77, 250–254.
22Slingerland, LI, Robben, JH, van Haeften, TW, et al. (2007) Insulin sensitivity and β-cell function in healthy cats: assessment with the use of the hyperglycaemic glucose clamp. Horm Metab Res 39, 341–346.
23Backus, RC, Havel, PJ, Gingerich, RL, et al. (2000) Relationship between serum leptin immunoreactivity and body fat mass as estimated by use of a novel gas-phase Fourier transformer infrared spectroscopy deuterium dilution method in cats. Am J Vet Res 61, 796–801.
24Darras, VM, Visser, TJ, Berghman, LR, et al. (1992) Ontogeny of type I and type III deiodinase activities in embryonic and posthatch chickens: relationship with changes in plasma triiodothyronine and growth hormone levels. Comp Biochem Physiol A Mol Integr Physiol 103, 131–136.
25Vreken, P, van Lint, AE, Bootsma, AH, et al. (1999) Rapid diagnosis of organic acidemias and fatty-acid oxidation defects by quantitative electrospray tandem-MS acyl-carnitine analysis in plasma. Adv Exp Med Biol 466, 327–337.
26Rizzo, C, Boenzi, S, Wanders, RJA, et al. (2003) Characteristic acyl-carnitine profiles in inherited defects of peroxisome biogenesis: a novel tool for screening diagnosis using tandem mass spectrometry. Pediatr Res 53, 1013–1018.
27Link, RJ & Rand, JS (1998) Reference values for glucose tolerance and glucose tolerance status in cats. J Am Vet Med Assoc 213, 492–496.
28Appleton, DJ, Rand, JS & Sunvold, GD (2005) Basal plasma insulin and homeostasis model assessment (HOMA) are indicators of insulin sensitivity in cats. J Feline Med Surg 7, 183–193.
29Nelson, RW, Himsel, CA, Feldman, EC, et al. (1990) Glucose tolerance and insulin response in normal weight and obese cats. Am J Vet Res 51, 1357–1362.
30Hoenig, M, Thomaseth, K, Brandao, J, et al. (2006) Assessment and mathematical modelling of glucose turnover and insulin sensitivity in lean and obese cats. Domest Anim Endocrinol 31, 373–389.
31Ruhl, CE & Everhart, JE (2003) Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 124, 71–79.
32Vozarova, B, Stefan, N, Lindsay, RS, et al. (2002) High alkaline aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 51, 1889–1895.
33Marchesini, G, Avagnina, S, Barantani, EG, et al. (2005) Aminotransferase and gamma-glutamyltranspeptidase levels in obesity are associated with insulin resistance and the metabolic syndrome. J Endocrinol Invest 28, 333–339.
34Barber, T, Vina, JR, Vina, J, et al. (1985) Decreased urea synthesis in cafeteria-diet-induced obesity in the rat. Biochem J 230, 675–681.
35Center, SA (1993) A retrospective study of 77 cats with severe hepatic lipidosis: 1975–1990. J Vet Int Med 7, 349–359.
36Levrat, M-A, Rémésy, C & Demigné, C (1991) High propionate fermentations and mineral accumulation in the caecum of rats adapted to different levels of inulin. J Nutr 121, 1730–1737.
37Delzenne, NM, Kok, N, Fiordaliso, M-F, et al. (1993) Dietary fructooligosaccharides modify lipid metabolism in rats. Am J Clin Nutr 57, 820S.
38Fiordaliso, M, Kok, N, Desager, J-P, et al. (1995) Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats. Lipids 30, 163–167.
39Agheli, N, Kabir, M, Berni-Canani, S, et al. (1998) Plasma lipids and fatty acid synthase activity are regulated by short chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats. J Nutr 128, 1283–1288.
40Busserolles, J, Gueux, E, Rock, E, et al. (2003) Oligofructose protects against hypertriglyceridemic and pro-oxidative effect of a high fructose diet in rats. J Nutr 133, 1903–1908.
41Kok, N, Roberfroid, M, Robert, A, et al. (1996) Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats. Br J Nutr 76, 881–890.
42Luo, J, Rizkalla, SW, Alamowitch, C, et al. (1996) Chronic consumption of short-chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism. Am J Clin Nutr 63, 939–945.
43Alles, MS, de Roos, NM, Bakx, JC, et al. (1999) Consumption of fructooligosaccharides does not favourably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes. Am J Clin Nutr 69, 64–69.
44Luo, J, Van Yperselle, M, Rizkalla, SW, et al. (2000) Chronic consumption of short-chain fructo-oligosaccharides does not affect basal hepatic glucose production or insulin resistance in type II diabetes. J Nutr 130, 1572–1577.
45Yamashita, K, Kawai, K & Itakura, K (1984) Effect of fructo-oligosaccharides on blood glucose and serum lipids in diabetic subjects. Nutr Res 4, 961–966.
46Hesta, M, Janssens, GPJ, Debraekeleer, J, et al. (2001) The effect of oligofructose and inulin on faecal characteristics and nutrient digestibility in healthy cats. J Anim Physiol Anim Nutr 85, 135–141.
47Jenkins, DJA, Wolever, TMS, Bacon, S, et al. (1980) Diabetic diets: high carbohydrate combined with high fiber. Am J Clin Nutr 33, 1729–1733.
48Nelson, RW, Ihle, SL, Lewis, LD, et al. (1991) Effects of dietary fiber supplementation on glycemic control in dogs with alloxan-induced diabetes mellitus. Am J Vet Res 52, 2060–2066.
49Storlien, LH, Baur, LA, Kriketos, AD, et al. (1996) Dietary fats and insulin action. Diabetologia 39, 621–631.
50Lichtenstein, AH & Swab, US (2000) Relationship of dietary fat to glucose metabolism. Atherosclerosis 150, 227–243.
51Thiess, S, Becskei, C, Tomsa, K, et al. (2004) Effects of high carbohydrate and high fat diet on plasma metabolite levels and on iv glucose tolerance test in intact and neutered male cats. J Feline Med Surg 6, 207–218.
52Brass, EP & Beyerinck, RA (1988) Effects of propionate and carnitine on the hepatic oxidation of short- and medium-chain length fatty acids. Biochem J 250, 819–825.
53Wolever, TMS, Brighenti, F, Royall, D, et al. (1989) Effect of rectal infusion of short chain fatty acids in human subjects. Am J Gastroenterol 84, 1027–1033.
54Judson, GJ, Anderson, E, Luick, JR, et al. (1968) The contribution of propionate to glucose synthesis in sheep given diets of different grain content. Br J Nutr 22, 69–75.
55Yost, WM, Young, JW, Schmidt, SP, et al. (1977) Gluconeogenesis in ruminants: propionic acid production from a high-grain diet fed to cattle. J Nutr 107, 2036–2043.
56Simmons, HA & Ford, EJ (1991) Gluconeogenesis from propionate produced in the colon of the horse. Br Vet J 147, 340–345.
57Blair, JB, Cook, DE & Lardy, HA (1973) Interaction of propionate and lactate in the perfused rat liver. J Biol Chem 248, 3608–3614.
58Anderson, JW & Bridges, SR (1984) Short chain fatty acid fermentation products of plant fiber affect glucose metabolism of isolated rat hepatocytes. Proc Soc Exp Biol Med 177, 372–376.