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Nutritional status of selenium in Alzheimer's disease patients

  • Bárbara Rita Cardoso (a1), Thomas Prates Ong (a1), Wilson Jacob-Filho (a2), Omar Jaluul (a2), Maria Isabel d'Ávila Freitas (a3) and Silvia M. Franciscato Cozzolino (a4)...


Studies have shown that various antioxidants are decreased in different age-related degenerative diseases and thus, oxidative stress would have a central role in the pathogenesis of many disorders that involve neuronal degeneration, including Alzheimer's disease (AD). The present study aimed to assess the nutritional status of Se in AD patients and to compare with control subjects with normal cognitive function. The case–control study was carried out on a group of elderly with AD (n 28) and compared with a control group (n 29), both aged between 60 and 89 years. Se intake was evaluated by using a 3-d dietary food record. Se was evaluated in plasma, erythrocytes and nails by using the method of hydride generation atomic absorption spectroscopy. Deficient Se intake was largely observed in the AD group. AD patients showed significantly lower Se levels in plasma, erythrocytes and nails (32·59 μg/l, 43·74 μg/l and 0·302 μg/g) when compared with the control group (50·99 μg/l, 79·16 μg/l and 0·400 μg/g). The results allowed us to suggest that AD has an important relation with Se deficiency.

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Corresponding author

*Corresponding author: Bárbara Rita Cardoso, fax +55 11 3091 3657, email


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1Butterfield, DA & Lauderback, CM (2002) Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radic Biol Med 32, 10501060.
2Lovell, MA & Markesbery, WR (2001) Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid. Arch Neurol 58, 392396.
3Mariani, E, Polidori, MC, Cherubini, A, et al. (2005) Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci 827, 6575.
4Chauhan, V & Chauhan, A (2006) Oxidative stress in Alzheimer's disease. Pathophysiology 13, 195208.
5Crouch, PJ, Harding, SME, White, AR, et al. (2008) Mechanisms of Aβ mediated neurodegeneration in Alzheimer's disease. Int J Biochem Cell Biol 40, 181198.
6Chen, J & Berry, MJ (2003) Selenium and selenoproteins in the brain and brain diseases. J Neurochem 86, 112.
7McKhann, G, Drachman, D, Folstein, M, et al. (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology 34, 939944.
8Folstein, MF, Folstein, SE & McHugh, PR (1975) ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189198.
9Seabra, MLV, Concílio, GV, Villarea, JB, et al. (1990) Avaliação do teste “Mini-mental state” em voluntários e pacientes brasileiros (Assessment test ‘Mini-Mental State’ in volunteers and patients in Brazil). Rev ABP-APL 12, 129.
10Ferreira, KS, Gomes, J, Bellato, CR, et al. (2002) Concentrações de selênio em alimentos consumidos no Brasil (Selenium content of Brazilian foods). Rev Panam Salud Publica 11, 172177.
11Philippi, ST (2001) Tabela de Composição de Alimentos: suporte para decisão nutricional (Adapted food pyramid: a guide for a right food choice). São Paulo: ANVISA, FINATEC/NUT-UnB.
12Willet, WC (1998) Nutritional Epidemiology, 2nd ed.New York: Oxford University Press.
13IOM – Institute of Medicine (2002) Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: The National Academy Press.
14Gonzaga, IB (2002) Avaliação nutricional relativa ao selênio em crianças com dieta enriquecida de castanha-do-Brasil (Bertholletia excelsa, L.) (Selenium nutritional status in children with diet enriched with Brazil nut (Bertholletia excelsa, L.)). PhD Thesis, University of São Paulo..
15Ortuño, J, Ros, G, Periago, MJ, et al. (1997) Importancia nutricional del selénio (Nutritional importance of selenium). Arc Latinoam Nutr 47, 613.
16Cozzolino, SMF (2007) Deficiências de minerais (Mineral deficiencies). Estudos Avançados 21, 119126.
17Combs, GF (2001) Selenium in global food systems. Br J Nutr 85, 517547.
18González, S, Huerta, JM, Fernández, S, et al. (2006) Food intake and serum selenium concentration in elderly people. Annu Nutr Metab 50, 126131.
19Al-Saleh, I, El-Doush, I, Billedo, G, et al. (2007) Status of selenium, vitamin E, and vitamin A among Saudi adults: potential links with common endemic diseases. J Environ Pathol Toxicol Oncol 26, 221243.
20Thomson, CD (2004) Selenium and iodine intakes and status in New Zealand and Australia. Br J Nutr 91, 661672.
21Navarro-Alarcon, M & Cabrera-Vique, C (2008) Selenium in food and the human body: a review. Sci Total Environ 400, 115141.
22Satia, JA, King, IB, Morris, JS, et al. (2006) Toenail and plasma levels as biomarkers of selenium exposure. Ann Epidemiol 16, 5358.
23Slotnick, MJ & Nriagu, JO (2006) Validity of human nails as a biomarker of arsenic and selenium exposure: a review. Environ Res 102, 125139.
24Ceballos-Picot, I, Merad-Boudia, M, Nicole, A, et al. (1996) Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer's type-place of the extracellular glutathione peroxidase. Free Radic Biol Med 20, 579587.
25Smorgon, C, Mari, E, Atti, AR, et al. (2004) Trace elements and cognitive impairment: an elderly cohort study. Arch Gerontol Geriatr 9, 393402.
26Berr, C, Balansard, B, Arnaud, J, et al. (2000) Cognitive decline is associated with systemic oxidative stress: the EVA study – Etude du Vieillissement Artériel. J Am Geriatr Soc 48, 12851291.
27Gao, S, Jin, Y, Hall, KS, et al. (2007) Selenium level and cognitive function in rural elderly Chinese. Am J Epidemiol 165, 955965.
28Akbaraly, NT, Hininger-Favier, I, Carrière, I, et al. (2007) Plasma selenium over time and cognitive decline in the elderly. Epidemiology 18, 5258.
29Chen, C, Lai, J, Wu, C, et al. (2006) Serum selenium in adult Taiwanese. Sci Total Environ 367, 448450.
30Arnaud, J, Akbaralyc, TN, Hininger, I, et al. (2007) Factors associated with longitudinal plasma selenium decline in the elderly: the EVA study. J Nutr Biochem 18, 482487.
31Letsiou, S, Nomikos, T, Panagiotakos, D, et al. (2009) Serum total selenium status in Greek adults and its relation to age. The ATTICA study cohort. Biol Trace Elem Res 128, 817.
32Planas, M, Conde, M, Audivert, S, et al. (2004) Micronutrient supplementation in mild Alzheimer disease patients. Clin Nutr 23, 265272.
33Benton, D (2002) Selenium intake, mood and other aspects of psychological functioning. Nutr Neurosci 5, 363374.
34Schweizer, U, Schomburg, L & Savaskan, NE (2004) The neurobiology of selenium: lessons from transgenic mice. J Nutr 134, 707710.
35Crack, PJ, Cimdins, K, Ali, U, et al. (2006) Lack of glutathione peroxidase-1 exacerbates αβ-mediated neurotoxicity in cortical neurons. J Neural Transm 113, 645657.
36Staehelin, HB (2005) Micronutrients and Alzheimer's disease. Proc Nutr Soc 64, 565570.
37Zhu, X, Lee, H, Perry, G, et al. (2007) Alzheimer disease, the two-hit hypothesis: an update. Biochim Biophys Acta 1772, 494502.
38Luchsinger, JA & Mayeux, R (2004) Dietary factors and Alzheimer's disease. Lancet Neurol 3, 579587.



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