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The nutritional status of children with cystic fibrosis

Published online by Cambridge University Press:  08 March 2007

Alexia J. Murphy ,
Helen M. Buntain ,
Claire E. Wainwright  and
Peter S. W. Davies
Alexia J. Murphy*
Affiliation:
Children's Nutrition Research Centre, Discipline of Paediatrics and Child Health, University of Queensland, Royal Children's Hospital, Brisbane, Queensland 4029, Australia
Helen M. Buntain
Affiliation:
Department of Respiratory Medicine, Royal Children's Hospital, Brisbane, Australia
Claire E. Wainwright
Affiliation:
Department of Respiratory Medicine, Royal Children's Hospital, Brisbane, Australia
Peter S. W. Davies
Affiliation:
Children's Nutrition Research Centre, Discipline of Paediatrics and Child Health, University of Queensland, Royal Children's Hospital, Brisbane, Queensland 4029, Australia
*
*corresponding author: fax +61 7 36361981, email alexia.murphy@uq.edu.au
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Abstract

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The importance of nutritional intervention for children with cystic fibrosis (CF) is well recognised. It would be expected that the increase in knowledge over the past decade would be reflected in improvements in nutritional status for the CF paediatric population. The aim of the present paper was to evaluate the nutritional status of children with CF, cross-sectionally and longitudinally. Body cell mass adjusted for gender and size (BCM/Htp) was measured in sixty-four children with CF to represent nutritional status and expressed as a Z-score. The cross-sectional results showed a mean BCM/Htp Z-score of 0·54 (sd 1·21), with males having a slightly higher Z-score than females but with a larger variation. At the initial measurement, only one female and one male were considered sub-optimally nourished. The longitudinal analysis after 2 years showed that the mean population had a significantly decreased BCM/Htp Z-score; however, when each gender was analysed separately, this decrease was significant only in the males. At the final measurement, only two females and three males were considered sub-optimally nourished. It is evident from our results that children with CF are well nourished, with only a small percentage considered malnourished. It appears that nutritional status decreases with age, with this decline being more evident in males. These results signify that although children with CF are better nourished with current treatment support, intervention needs to continue throughout a CF patient's life to counteract the changes that occur with age.

Keywords

Cystic fibrosisNutritional statusBody cell mass
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 2 , February 2006 , pp. 321 - 324
Copyright
Copyright © The Nutrition Society 2006

References

Ahmed, ML, Ong, KK, Thomson, AH & Dunger, DBReduced gains in fat and fat-free mass, and elevated leptin levels in children and adolescents with cystic fibrosis. Acta Paediatr 2004 93 1185–1191CrossRefGoogle Scholar
Borowitz, D, Baker, RD & Stallings, VConsensus report on nutrition for pediatric patients with cystic fibrosis J Pediatr Gastroenterol Nutr 2002 35 246–259Google ScholarPubMed
Buntain, HM, Greer, RM, Schluter, PJ, Wong, JC,Batch, JA, Potter, JM,Lewindon, PJ, Powell, E, Wainwright, CE & Bell, SCBone mineral density in Australian children, adolescents and adults with cystic fibrosis: a controlled cross sectional study. Thorax 2004 59 149–155CrossRefGoogle ScholarPubMed
Corey, M, McLaughlin, FJ, Williams, M & Levison, HA comparison of survival, growth and pulmonary function in patients with cystic fibrosis in Boston and Toronto. J Clin Epidemiol 1988 41 583–591CrossRefGoogle ScholarPubMed
Dodge, J, Morison, S, Lewis, P, Coles, E, Geddes, D, Russell, G, Littlewood, J & Scott, MIncidence, population, and survival of cystic fibrosis in the UK, 1968–95. UK Cystic Fibrosis Survey Management Committee. Arch Dis Child 1997 77 493–496CrossRefGoogle ScholarPubMed
Groeneweg, M, Tan, S, Boot, AM, de Jongste, JC, Bouquet, J & Sinaasappel, MAssessment of nutritional status in children with cystic fibrosis: conventional anthropometry and bioelectrical impedance analysis. A cross sectional study in Dutch patients. J Cyst Fibros 2002 1 276–280CrossRefGoogle ScholarPubMed
Hibbert, ME, Lannigan, A, Landau, LI & Phelan, PDLung function values from a longitudinal study of healthy children and adolescents. Pediatr Pulmonol 1989 7 101–109CrossRefGoogle ScholarPubMed
McNaughton, SA, Shepherd, RW, Greer, RG, Cleghorn, GJ & Thomas, BJNutritional status of children with cystic fibrosis measured by total body potassium as a marker of body cell mass: lack of sensitivity of anthropometric measures. J Pediatr 2000 136 188–194CrossRefGoogle ScholarPubMed
Marín, VB, Velandia, S, Hunter, B,Gattas, V, Fielbaum, O, Herrera, O & Díaz, EEnergy expenditure, nutrition status, and body composition in children with cystic fibrosis. Nutrition 2004 20 181–186CrossRefGoogle ScholarPubMed
Moore, FDEnergy and the maintenance of the body cell mass. J Parenter Enteral Nutr 1980 4 228–260CrossRefGoogle ScholarPubMed
National Center for Health Statistics/Centers for Disease Control and Prevention 2000 CDC Growth Charts. Selected percentiles and LMS parameters. 2004Google Scholar
Rosenfeld, M, Davis, R, FitzSimmons, S, Pepe, M & Ramsey, BGender gap in cystic fibrosis mortality. Am J Epidemiol 1997 145 794–803CrossRefGoogle ScholarPubMed
Sharma, M & Singh, MNutritional management of children with cystic fibrosis. Indian Pediatr 2003 40 1055–1062Google ScholarPubMed
Shepherd, RW, Greer, RM, McNaughton, SA, Wotton, M & Cleghorn, GJEnergy expenditure and the body cell mass in cystic fibrosis. Nutrition 2001 17 22–25CrossRefGoogle ScholarPubMed
Shepherd, RW, Holt, TL, Johnson, LP, Quirk, P & Thomas, BJLeucine metabolism and body cell mass in cystic fibrosis. Nutrition 1995 11 138–141Google ScholarPubMed
Sinaasappel, M, Stern, M, Littlewood, J, Wolfe, S, Steinkamp, G, Heijerman, HGM, Robberecht, E & Doring, GNutrition in patients with cystic fibrosis: a European Consensus. J Cyst Fibros 2002 1 51–75CrossRefGoogle ScholarPubMed
Sood, M, Adams, J & Mughal, MLean body mass in children with cystic fibrosis Arch Dis Child 2003 88 836CrossRefGoogle ScholarPubMed
Stapleton, D, Kerr, D, Gurrin, L, Sherriff, J & Sly, PHeight and weight fail to detect early signs of malnutrition in children with cystic fibrosis. J Pediatr Gastroenterol Nutr 2001 33 319–325Google ScholarPubMed
Stettler, N,Kawchak, DA, Boyle, LL, Propert, KJ, Scanlin, TF, Stallings, VA & Zemel, BSProspective evaluation of growth, nutritional status, and body composition in children with cystic fibrosis. Am J Clin Nutr 2000 72 407–413CrossRefGoogle ScholarPubMed
Wang, Z, St Onge, MP, Lecumberri, Bet al. Body cell mass: model development and validation at the cellular level of body composition. Am J Physiol Endocrinol Metab 2004 286 E123–E128CrossRefGoogle ScholarPubMed
Wells, JCK, Murphy, AJ, Buntain, HM, Greer, RM, Cleghorn, GJ & Davies, PSAdjusting body cell mass for size in women of differing nutritional status. Am J Clin Nutr 2004 80 333–336CrossRefGoogle ScholarPubMed
White, M, Murphy, AJ, Hastings, Y, Shergold, J, Young, J, Montgomery, C, Davies, PS & Lockwood, LNutritional status and energy expenditure in children pre-bone-marrow-transplant. Bone Marrow Transplant 2005 35 775–779CrossRefGoogle ScholarPubMed