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Necessity of vitamin B12 for growth of rats fed on an odd- or even-carbon-number fat

Published online by Cambridge University Press:  26 April 2012

J. Bitman ,
Joan R. Weyant ,
D. L. Wood  and
T. R. Wrenn
J. Bitman
Affiliation:
Nutrient Utilization Laboratory, Animal Physiology and Genetics Institute, ARS, US Department of Agriculture, Beltsville, Maryland 20705, USA
Joan R. Weyant
Affiliation:
Nutrient Utilization Laboratory, Animal Physiology and Genetics Institute, ARS, US Department of Agriculture, Beltsville, Maryland 20705, USA
D. L. Wood
Affiliation:
Nutrient Utilization Laboratory, Animal Physiology and Genetics Institute, ARS, US Department of Agriculture, Beltsville, Maryland 20705, USA
T. R. Wrenn
Affiliation:
Nutrient Utilization Laboratory, Animal Physiology and Genetics Institute, ARS, US Department of Agriculture, Beltsville, Maryland 20705, USA
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Abstract

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1. The effect of vitamin B12 on growth was studied in young male and female rats fed on diets sufficient (+B12) or deficient (−B12) in vitamin B12 containing 30% of the dietary energy as fat, either maize oil (CO) or triundecanoin (TUD).

2. Vitamin B12 deficiency severely depressed growth. After 6 weeks the weight gain of CO(−B12) rats was only 72% of that of CO(+B12) rats and the gain of TUD(−B12) rats was only 47% of TUD(+B12) rats.

3. After fasting 24 or 96 h TUD-fed rats, both + B12 and −B12, had greater glycogen reserves and higher plasma glucose levels than CO-fed rats.

4. It is concluded that vitamin B12 is required for the metabolism and utilization of both an odd-carbon-number medium-chain fat, TUD, and an even-C-number long-chain fat, CO, during growth in rats.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 39 , Issue 3 , May 1978 , pp. 615 - 626
Copyright
Copyright © The Nutrition Society 1978

References

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