Hostname: page-component-848d4c4894-4rdrl Total loading time: 0 Render date: 2024-06-19T02:28:10.451Z Has data issue: false hasContentIssue false
  • English
  • Français

Modulation of postprandial glycaemia and insulinaemia by cellulose in mixed nutrient combinations

Published online by Cambridge University Press:  09 March 2007

Anupa Siddhu ,
Sudha Sud ,
R. L. Bijlani ,
M. G. Karmarkar  and
Usha Nayar
Anupa Siddhu
Affiliation:
Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029, India
Sudha Sud
Affiliation:
Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029, India
R. L. Bijlani
Affiliation:
Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029, India
M. G. Karmarkar
Affiliation:
Department of Endocrinology, All India Institute of Medical Sciences, New Delhi 110 029, India
Usha Nayar
Affiliation:
Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029, India
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The present study was designed to examine the effect of cellulose (CL) on postprandial glycaemia and insulinaemia when ingested with glucose (G), casein (CS) and maize oil (CO) in various combinations. The study was conducted on five healthy male volunteers, on each of whom five meal tolerance tests were performed. The meals were isoenergetic and consisted of G; G and CL; G, CS and CL; G, CO and CL; G, CS, CO and CL. The meals were administered after an overnight fast. In addition to a fasting venous blood sample, blood was collected 0.5, 1.0, 1.5 and 2.0 h after ingestion for measurement of serum glucose and insulin levels. The glycaemic response to G+CS+CL and G+CS+CO+CL was significantly lower, while the insulinaemic response to G+CL was significantly higher than that to G. Addition of CL to G did not alter the glycaemic response, but accentuated the insulinaemic response. Further addition of CS in isoenergetic meals attenuated the glycaemic response, which may be because of a reduction in the amount of G in the meals. Like CS, CL also seemed to have an insulinotropic effect. The mechanism of the insulinotropic effect of CL cannot be deduced from the present study, but it is possible that like G, CL also stimulates gastric inhibitory peptide (GIP) secretion from the duodenum, which in turn stimulates insulin secretion.

Keywords

CelluloseGlucose tolerance testGlycaemic index
Type
Research Article
Information
British Journal of Nutrition , Volume 62 , Issue 1 , July 1989 , pp. 131 - 137
Copyright
Copyright © The Nutrition Society 1989

References

REFERENCES

Armitage, P. (1971). Statistical Methods in Medical Research, pp. 203–207. Oxford: Blackwell Scientific Publications.Google Scholar
Berger, S. & Vougaraya, N. (1966). Insulin response to ingested protein in diabetes. Diabetes 15, 303–306.CrossRefGoogle ScholarPubMed
Bijlani, R.L., Gandhi, B.M., Gupta, M.C., Manocha, S. & Tandon, B.N. (1985). Effect of whole buckwheat (Fagopyrum esculentum) flour supplementation on lipid profile and glucose tolerance. Indian Journal of Medical Research 81, 162–168.Google ScholarPubMed
Bijlani, R.L., Mahapatra, S.C., Sahi, A., Sud, S., Thomas, S. & Nayar, U. (1986). Effect of Isabgol and cellulose on the digestion and absorption of sucrose by everted sacs of adult hamster intestine. Tropical Gastroenterology 7, 18–23.Google ScholarPubMed
Blackburn, N.A., Holgate, A.M. & Read, N.W. (1984). Does guar gum improve postprandial hyperglycaemia in humans by reducing small intestinal contact area? British Journal of Nutrition 52, 197–204.CrossRefGoogle ScholarPubMed
Cassidy, M.M., Lightfoot, P.G., Grau, L.E., Story, J.A., Kritchevsky, D. & Vahouny, G.V. (1981). Effect of chronic intake of dietary fibers on the ultrastructural topography of rat jejunum and colon: a scanning electron microscopy study. American Journal of Clinical Nutrition 34, 218–228.CrossRefGoogle Scholar
Collier, G.R., Wolever,, T.M.S., Wong, G.S. & Josse, R.G. (1986). Prediction of glycemic response to mixed meals in non-insulin-dependent diabetic subjects. American Journal of Clinical Nutrition 44, 349–352.CrossRefGoogle Scholar
Estrich, D., Ravnik, A., Schlierf, G., Fukuyama, G. & Kinsell, A. (1967). Effect of coingestion of fat and protein upon carbohydrate-induced hyperglycemia. Diabetes 16, 232–237.CrossRefGoogle ScholarPubMed
Farness, P.L. & Schneeman, B.O. (1982). Effect of dietary cellulose, pectin and oat bran on the small intestine in the rat. Journal of Nutrition 112, 1315–1319.CrossRefGoogle ScholarPubMed
Flatt, P.R. & Bailey, C.J. (1984). Dietary components and plasma insulin response to fasting and refeeding in genetically obese hyperglycaernic (ob/ob) mice. British Journal of Nutrition 51, 403–413.CrossRefGoogle ScholarPubMed
Florholmen, J., Arvidsson-Lenner, R., Jorde, R. & Burhol, P.G. (1982). The effect of metamucil on postprandial blood glucose and plasma gastric inhibitory peptide on insulin dependent diabetics. Acta Medica Scandinavica 212, 237–239.CrossRefGoogle ScholarPubMed
Jarjis, H.A., Blackburn, N.A., Redfern, J.S. & Read, N.W. (1984). The effect of ispaghula (Fybogel and Metamucil) and guar gum on glucose tolerance in man. British Journal of Nutrition 51, 371–378.CrossRefGoogle ScholarPubMed
Jeffrys, D.B. (1974). The effect of dietary fibre on the response to orally administered glucose. Proceedings of the Nutrition Society 33, 11A.Google ScholarPubMed
Jenkins, D.J.A., Ghafari, H., Wolever,, T.M.S., Taylor, R.H., Jenkins, A.L., Barker, H.M., Fielden, H. & Bowling, A.C. (1982). Relationship between rate of digestion of food and postprandial glycaemia. Diabetologia 22, 450–455.CrossRefGoogle Scholar
Jenkins, D.J.A., Goff, D.V., Leeds, A.R., Alberti, K.G.M.M., Wolever,, T.M.S., Gassull, M.A. & Hockaday, T.D.R. (1976). Unabsorbable carbohydrates and diabetes: decreased postprandial hyperglycaemia. Lancet ii, 172–174.CrossRefGoogle Scholar
Jenkins, D.J.A., Leeds, A.R., Miguel, A., Gassull, M.A., Cochet, B. & Alberti, K.G.M.M. (1977). Decrease in postprandial insulin and glucose concentration by guar and pectin. Annals of Internal Medicine 86, 20–23.CrossRefGoogle ScholarPubMed
Jenkins, D.J.A., Wolever,, T.M.S., Leeds, A.R., Gassull, M.A., Haisman, P., Dilawari, J., Goff, D.V., Metz, G.L. & Alberti, K.G.M.M. (1978). Dietary fibre, fibre analogues and glucose tolerance: importance of viscosity. British Medical Journal i, 1392–1394.CrossRefGoogle Scholar
Jenkins, D.J.A., Wolever,, T.M.S., Taylor, R.H., Barker, H., Fielden, H., Baldwin, J.M., Bowling, A.C., Newman, H.C., Jenkins, A.L. & Goff, D.V. (1981). Glycemic index of foods: a physiological basis for carbohydrate exchange. American Journal of Clinical Nutrition 34, 362–366.CrossRefGoogle Scholar
Mahapatra, S.C., Bijlani, R.L. & Nayar, U. (1988). Effect of cellulose and ispaghula on intestinal function of hamsters maintained on diets of varying fibre content. Indian Journal of Medical Research 88, 175–180.Google ScholarPubMed
Pederson, O., Hjollund, E., Lindskov, H.O., Helms, P., Sorensen, N.S. & Ditzel, J. (1982). Increased insulin receptor binding to monocytes from insulin-dependent diabetic patients after a low-fat, high-starch, high-fiber diet. Diabetes Care 5, 284–291.CrossRefGoogle Scholar
Potter, J.G., Coffman, K.P., Reid, R.L., Krall, J.M. & Albrink, M.J. (1981). Effect of test meals of varying dietary fiber content on plasma insulin and glucose response. American Journal of Clinical Nutrition 34, 328–334.CrossRefGoogle ScholarPubMed
Rabinowitz, D., Merimee, T.J., Maffezzoli, R. & Burgess, J.A. (1966). Patterns of hormonal release after glucose, protein and glucose plus protein. Lancet ii, 454–457.CrossRefGoogle Scholar
Sahi, A., Bijlani, R.L., Karmarkar, M.G. & Nayar, U. (1985). Modulation of glycaemic response by protein, fat and dietary fibre. Nutrition Research 5, 1431–1435.CrossRefGoogle Scholar
Sartor, G., Carlstrom, S. & Schersten, B. (1981). Dietary supplementation of fiber (Lunelax) as a means to reduce postprandial glucose in diabetics. Acta Medica Scandinavica 656, Suppl., 51–53.Google Scholar
Stanley, J.C. & Newsholme, E.A. (1985). The effect of dietary guar gum on the activities of some key enzymes of carbohydrate and lipid metabolism in mouse liver. British Journal of Nutrition 53, 215–222.CrossRefGoogle ScholarPubMed
Sud, S., Siddhu, A. & Bijlani, R.L. (1988). Effect of ispaghula husk on postprandial glycemia and insulinemia following glucose and starch drinks. Nutrition 4, 221–223.Google Scholar
Thorburn, A.W., Brand, J.C. & Truswell, A.S. (1986). Salt and glycaemic response. British Medical Journal 292, 1697–1699.CrossRefGoogle ScholarPubMed
Vaaler, S., Hanssen, K.F. & Aagenaes, O. (1980). Effect of different kinds of fibre on postprandial blood glucose in insulin-dependent diabetics. Acta Medica Scandinavica 208, 389–391.CrossRefGoogle ScholarPubMed
Villaume, C., Beck, B., Gariot, P., Desalme, A. & Debry, G. (1984). Long-term evolution of the effect of bran ingestion on meal-induced glucose and insulin responses in healthy man. American Journal of Clinical Nutrition 40, 1023–1026.CrossRefGoogle ScholarPubMed