1 Wilson, W, D'Agostino, R, Parise, H, et al. (2005) Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation 112, 3066–3072.
2 Dekker, J, Girman, C, Rhodes, T, et al. (2005) Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study. Circulation 112, 666–673.
3 Ford, E, Giles, W & Dietz, W (2002) Prevalence of the metabolic syndrome among US adults: findings from the Third National Health and Nutrition Examination Survey. JAMA 287, 356–359.
4 Ruhe, RC & McDonald, RB (2001) Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes. J Am Coll Nutr 20, 363S–369S, .
5 Ford, ES, Will, JC, Bowman, BA, et al. (1999) Diabetes mellitus and serum carotenoids: findings from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 149, 168–176.
6 Coyne, T, Ibiebele, T, Baade, P, et al. (2005) Diabetes mellitus and serum carotenoids: findings of a population-based study in Queensland, Australia. Am J Clin Nutr 82, 685–693.
7 Suzuki, K, Ito, Y, Nakamura, S, et al. (2002) Relationship between serum carotenoids and hyperglycemia: a population-based cross-sectional study. J Epidemiol 12, 357–366.
8 Hozawa, A, Jacobs, DR, Steffes, MW, et al. (2006) Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) Study. Clin Chem 53, 447–455.
9 D'Odorico, A, Martines, D, Kiechl, S, et al. (2000) High plasma levels of alpha- and beta-carotene are associated with a lower risk of atherosclerosis. Results from the Bruneck Study. Atherosclerosis 153, 231–239.
10 Ito, Y, Suzuki, K, Ishii, J, et al. (2006) A population-based follow-up study on mortality from cancer or cardiovascular disease and serum carotenoids, retinol and tocopherols in Japanese inhabitants. Asian Pac J Cancer Prev 7, 533–546.
11 Daviglus, ML, Orencia, AJ, Dyer, AR, et al. (1997) Dietary vitamin C, beta-carotene and 30-year risk of stroke: results from the Western Electric Study. Neuroepidemiology 16, 69–77.
12 Hozawa, A, Jacobs, DR Jr, Steffes, MW, et al. (2009) Circulating carotenoid concentrations and incident hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study. J Hypertens 27, 237–242.
13 Giovannucci, E, Rimm, EB, Liu, Y, et al. (2002) A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst 94, 391–398.
14 D'Odorico, A, Bortolan, S, Cardin, R, et al. (2001) Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease. Scand J Gastroenterol 36, 1289–1294.
15 Brazionis, L, Rowley, K, Itsiopoulos, C, et al. (2008) Plasma carotenoids and diabetic retinopathy. Br J Nutr 13, 1–8.
16 Eitenmiller, RR & Landen, WO (editors) (1999) Vitamin Analysis for the Health and Food Sciences. Boca Raton, FL: CRC Press.
17 Esmaillzadeh, A, Kimiagar, M, Mehrabi, Y, et al. (2007) Dietary patterns, insulin resistance, and prevalence of the metabolic syndrome in women. Am J Clin Nutr 85, 910–918.
18 Esmaillzadeh, A, Kimiagar, M, Mehrabi, Y, et al. (2006) Fruit and vegetable intakes, C-reactive protein, and the metabolic syndrome. Am J Clin Nutr 84, 1489–1497.
19 Ford, ES, Mokdad, AH, Giles, WH, et al. (2003) The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey. Diabetes 52, 2346–2352.
20 Yoo, S, Nicklas, T, Baranowski, T, et al. (2004) Comparison of dietary intakes associated with metabolic syndrome risk factors in young adults: the Bogalusa Heart Study. Am J Clin Nutr 80, 841–848.
21 Lutsey, PL, Steffen, LM & Stevens, J (2008) Dietary intake and the development of the metabolic syndrome: the Atherosclerosis Risk in Communities Study. Circulation 117, 754–761.
22 Liu, S, Ajani, U, Chae, C, et al. (1999) Long-term beta-carotene supplementation and risk of type2 diabetes mellitus: a randomised controlled trial. JAMA 282, 1073–1075.
23 Ford, E, Mokdad, A, Giles, W, et al. (2003) The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey. Diabetes Care 2, 2346–2352.
24 Sugiura, M, Nakamura, M, Ogawa, K, et al. (2008) Associations of serum carotenoid concentrations with the metabolic syndrome: interaction with smoking. Br J Nutr 29, 1–10.
25 Dunstan, DW, Zimmet, PZ, Welborn, TA, et al. (2002) The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care 25, 829–834.
26 Dunstan, DW, Zimmet, PZ, Welborn, TA, et al. (2002) The Australian Diabetes, Obesity and Lifestyle Study (AusDiab) – methods and response rates. Diabetes Res Clin Pract 57, 119–129.
27 Friedewald, WT, Levy, R & Fredrickson, DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without the use of the preparative ultracentrifuge. Clin Chem 18, 499–502.
28 Talwar, D, Ha, TK, Cooney, J, et al. (1998) A routine method for the simultaneous measurement of retinol, alpha-tocopherol and five carotenoids in human plasma by reverse phase HPLC. Clin Chim Acta 270, 85–100.
29 Alberti, K, Zimmet, PZ & Shaw, JE (2006) Metabolic syndrome – a new world-wide definition. A concensus statement from the International Diabetes Federation. Diabet Med 23, 469–480.
30 Stata Corporation (2003) Stata/SE Statistical Software: Release 8.0 for Windows. College Station, TX: Stata Corporation.
31 Andersen, LF, Jacobs, DR Jr, Gross, MD, et al. (2006) Longitudinal associations between body mass index and serum carotenoids: the CARDIA Study. Br J Nutr 95, 358–365.
32 Coyne, T, Ibiebele, TI, McNaughton, S, et al. (2005) Evaluation of brief dietary questions to estimate vegetable and fruit consumption – using serum carotenoids and red-cell folate. Public Health Nutr 8, 298–308.
33 Millen, BE, Pencina, MJ, Kimokoti, RW, et al. (2006) Nutritional risk and the metabolic syndrome in women: opportunities for preventive intervention from the Framingham Nutrition Study. Am J Clin Nutr 84, 434–441.
34 Dietrich, M, Block, G, Norkus, EP, et al. (2003) Smoking and exposure to environmental tobacco smoke decrease some plasma antioxidants and increase – tocopherol in vivo after adjustment for dietary antioxidant intakes. Am J Clin Nutr 77, 160–166.
35 Hozawa, A, Jacobs, DR Jr, Steffes, MW, et al. (2006) Associations of serum carotenoid concentrations with the development of diabetes and with insulin concentration: interaction with smoking: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Epidemiol 163, 929–937.
36 Redon, J, Oliva, M, Tormos, C, et al. (2003) Antioxidant activities and oxidative stress byproducts in human hypertension. Hypertension 41, 1096–1101.
37 Furukawa, S, Fujita, T, Shimabukuro, M, et al. (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114, 1752–1761.
38 Hansel, B, Giral, P, Nobecourt, E, et al. (2004) Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity. J Clin Endocrinol Metab 89, 4963–4971.
39 Montonen, J, Knekt, P, Jarvinen, R, et al. (2004) Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 27, 362–366.
40 Sargent, L, Khaw, K, Bingham, S, et al. (2001) Fruit and vegetable intake and population glycosylated haemoglobin levels: the EPIC–Norfolk Study. Eur J Clin Nutr 55, 342–348.
41 Tuomilehto, J, Lindstrom, J, Eriksson, J, et al. (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New Engl J Med 344, 1343–1350.
42 Diabetes Prevention Program Research Group (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. New Engl J Med 346, 393–403.