Skip to main content Accessibility help
×
Home

Maternal serum concentrations of insulin-like growth factor (IGF)-I and IGF binding protein-1 before and during pregnancy in relation to maternal body weight and composition and infant birth weight

  • Hanna Olausson (a1) (a2), Marie Löf (a1), Kerstin Brismar (a3), Elisabet Forsum (a1) and Annica Sohlström (a1)...

Abstract

Maternal nutritional status, e.g. body weight and composition, is associated with fetal growth. It has been suggested that the insulin-like growth factor (IGF) system may be a mediator of this relationship. In twenty-three healthy Swedish women, we studied (1) the relationships before and during pregnancy between maternal serum concentrations of IGF-I and IGF binding protein-1 (IGFBP-1) and maternal body weight and composition; (2) interactions between serum concentrations of IGF-I (before and in early pregnancy) and maternal nutritional status in relation to infant birth weight. We found that serum IGF-I during pregnancy was positively correlated with maternal body weight (r 0·47–0·56) and fat-free body weight (r 0·61–0·65), whereas serum IGFBP-1 was negatively correlated with maternal body weight (r − 0·44 to − 0·69) and body fat (r − 0·64 to − 0·76) before and during pregnancy. Women with a lower body fat content (%) before pregnancy had greater increases in serum IGFBP-1 during pregnancy than women with a higher prepregnant body fat content (%). In addition, significant fractions of the variation in corrected infant birth weight were explained by variables related to the maternal nutritional status when these were combined with serum concentrations of IGF-I in gestational week 14 (adjusted r2 0·25–0·44, P = 0·001–0·021), but not when they were combined with such concentrations before pregnancy (adjusted r2 0·11–0·12, P = 0·105–0·121). These results suggest mechanisms by which the IGF system may be a mediator between maternal nutritional status and fetal growth.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Maternal serum concentrations of insulin-like growth factor (IGF)-I and IGF binding protein-1 before and during pregnancy in relation to maternal body weight and composition and infant birth weight
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Maternal serum concentrations of insulin-like growth factor (IGF)-I and IGF binding protein-1 before and during pregnancy in relation to maternal body weight and composition and infant birth weight
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Maternal serum concentrations of insulin-like growth factor (IGF)-I and IGF binding protein-1 before and during pregnancy in relation to maternal body weight and composition and infant birth weight
      Available formats
      ×

Copyright

Corresponding author

*Corresponding author: Hanna Olausson, fax +46 31 7863101, email hanna.olausson@gu.se

References

Hide All
1 Butte, NF, Ellis, KJ, Wong, WW, et al. (2003) Composition of gestational weight gain impacts maternal fat retention and infant birth weight. Am J Obstet Gynecol 189, 14231432.
2 Baker, JL, Michaelsen, KF, Rasmussen, KM, et al. (2004) Maternal prepregnant body mass index, duration of breastfeeding, and timing of complementary food introduction are associated with infant weight gain. Am J Clin Nutr 80, 15791588.
3 Owens, JA (1991) Endocrine and substrate control of fetal growth: placental and maternal influences and insulin-like growth factors. Reprod Fertil Dev 3, 501517.
4 Thissen, JP, Ketelslegers, JM & Underwood, LE (1994) Nutritional regulation of the insulin-like growth factors. Endocr Rev 15, 80101.
5 Roberts, CT, Owens, JA, Sferruzzi-Perri, AN, et al. (2008) Distinct actions of insulin-like growth factors (IGFs) on placental development and fetal growth: lessons from mice and guinea pigs. Placenta 29, Suppl. A, S42S47.
6 Forbes, K & Westwood, M (2008) The IGF axis and placental function. A mini review. Horm Res 69, 129137.
7 Gargosky, SE, Owens, JA, Walton, PE, et al. (1991) Administration of insulin-like growth factor-I, but not growth hormone, increases maternal weight gain in late pregnancy without affecting fetal or placental growth. J Endocrinol 130, 395400.
8 Jones, JI & Clemmons, DR (1995) Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16, 334.
9 Sakai, K, Iwashita, M & Takeda, Y (1997) Profiles of insulin-like growth factor binding proteins and the protease activity in the maternal circulation and its local regulation between placenta and decidua. Endocr J 44, 409417.
10 Skjaerbaek, C, Frystyk, J, Orskov, H, et al. (2004) Free IGF-I, IGFBP-1, and binary complex of IGFBP-1 and IGF-I are increased during human pregnancy. Horm Res 62, 215220.
11 Giudice, LG, Farrell, EM, Pham, H, et al. (1990) Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium: effects of a pregnancy-associated serum protease activity. J Clin Endocrinol Metab 71, 806816.
12 Olausson, H, Lof, M, Brismar, K, et al. (2008) Longitudinal study of the maternal insulin-like growth factor system before, during and after pregnancy in relation to fetal and infant weight. Horm Res 69, 99106.
13 Frystyk, J, Hojlund, K, Rasmussen, K, et al. (2002) Development and clinical evaluation of a novel immunoassay for the binary complex of IGF-I and IGF-binding protein-1 in human serum. J Clin Endocrinol Metab 87, 260266.
14 Baxter, R (1995) Insulin-like growth factor binding proteins as glucoregulators. Metabolism 44, 1217.
15 Hall, K, Hansson, U, Lundin, G, et al. (1986) Serum levels of somatomedins and somatomedin-binding protein in pregnant women with type 1 or gestational diabetes and their infants. J Clin Endocrinol Metab 63, 13001306.
16 Caufriez, A, Frankenne, F, Hennen, G, et al. (1993) Regulation of maternal IGF-I by placental GH in normal and abnormal human pregnancies. Am J Physiol Endocrinol Metab 265, E572E577.
17 Boyne, MS, Thame, M, Bennett, FI, et al. (2003) The relationship among circulating insulin-like growth factor (IGF)-I, IGF-binding proteins-1 and -2, and birth anthropometry: a prospective study. J Clin Endocrinol Metab 88, 16871691.
18 Clapp, JE, Schmidt, S, Paranjape, A, et al. (2004) Maternal insulin-like growth factor-I levels (IGF-I) reflect placental mass and neonatal fat mass. Am J Obstetr Gynecol 190, 730736.
19 Hills, FA, English, J & Chard, T (1996) Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight. J Endocrinol 148, 303309.
20 Lukanova, A, Lundin, E, Zeleniuch-Jacquotte, A, et al. (2004) Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein-3: a cross-sectional study in healthy women. Eur J Endocrinol 150, 161171.
21 Jernström, H & Olsson, H (1998) Insulin-like growth factor-1 in relation to adult weight and birth weight in healthy nulliparous women. Int J Gynecol Obstetr 62, 1118.
22 Ahmed, RL, Thomas, W & Schmitz, KH (2007) Interactions between insulin, body fat, and insulin-like growth factor axis proteins. Cancer Epidemiol Biomarkers Prev 16, 593597.
23 Baldwin, S, Chung, T, Rogers, M, et al. (1993) Insulin-like growth factor-binding protein-1, glucose tolerance and fetal growth in human pregnancy. J Endocrinol 136, 319325.
24 Holmes, RP, Holly, JMP & Soothill, PW (2000) Maternal insulin-like growth factor binding protein-1, body mass index, and fetal growth. Arch Dis Child Fetal Neonatal Ed 82, F113F117.
25 Lof, M, Olausson, H, Bostrom, K, et al. (2005) Changes in basal metabolic rate during pregnancy in relation to changes in body weight and composition, cardiac output, insulin-like growth factor-I, thyroid hormones and in relation to fetal growth. Am J Clin Nutr 81, 678685.
26 Lof, M & Forsum, E (2006) Activity pattern and energy expenditure due to physical activity before and during pregnancy in healthy Swedish women. Br J Nutr 95, 296302.
27 Lof, M & Forsum, E (2004) Hydration of fat-free mass in healthy women with special reference to the effect of pregnancy. Am J Clin Nutr 80, 960965.
28 Forsum, E, Lof, M, Olausson, H, et al. (2006) Maternal body composition in relation to infant birth weight and subcutaneous adipose tissue. Br J Nutr 96, 408414.
29 Eriksson, B, Lof, M, Olausson, H, et al. (2009) Body fat, insulin resistance, energy expenditure and serum concentrations of leptin, adiponectin and resistin before, during and after pregnancy in healthy Swedish women. Br J Nutr 103, 5057.
30 Jorgensen, C (1997) Fetometri och graviditetslängdbestämning (Fetometri and gestational age determination). In Obstetriskt ultraljud (Obstetric Ultrasound), pp. 3744 [Svensk förening för obstetril och gynekologi: and Arbets- och referensgrupp för ultraljudsdiagnostik, editor]. Västerås: Västra Aros Tryckeri AB.
31 Niklasson, A & Karlberg, P (1993) Weight-for-length model in newborn Swedish infants. Acta Paediatr 82, 333339.
32 Bang, P, Eriksson, U, Sara, V, et al. (1991) Comparison of acid ethanol extraction and acid gel filtration prior to IGF-I and IGF-II radioimmunoassays: improvements of determinations in acid ethanol extracts by the use of truncated IGF-I as radioligand. Acta Endocrinol 124, 620629.
33 Póvoa, G, Roovete, A & Hall, K (1984) Cross-reaction of serum somatomedin-binding protein in a radioimmunoassay developed for somatomedin-binding protein isolated from human amniotic fluid. Acta Endocrinol 107, 563570.
34 Ostlund, I, Hanson, U, Bjorklund, A, et al. (2003) Maternal and fetal outcomes if gestational impaired glucose tolerance is not treated. Diabetes Care 26, 21072111.
35 Jansson, T, Cetin, I, Powell, TL, et al. (2006) Placental transport and metabolism in fetal overgrowth – a workshop report. Placenta 27, Suppl. A, S109S113.
36 Franks, PW, Looker, HC, Kobes, S, et al. (2006) Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring. Diabetes 55, 460465.

Keywords

Maternal serum concentrations of insulin-like growth factor (IGF)-I and IGF binding protein-1 before and during pregnancy in relation to maternal body weight and composition and infant birth weight

  • Hanna Olausson (a1) (a2), Marie Löf (a1), Kerstin Brismar (a3), Elisabet Forsum (a1) and Annica Sohlström (a1)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed