1Jemal, A, Siegel, R, Ward, E, Murray, T, Xu, J & Thun, MJ (2007) Cancer statistics, 2007. CA Cancer J Clin 57, 43–66.
2Kinzler, KW & Vogelstein, B (1996) Lessons from hereditary colorectal cancer. Cell 87, 159–170.
3Corpet, DE & Pierre, F (2003) Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. Cancer Epidemiol Biomarkers Prev 12, 391–400.
4Misikangas, M, Pajari, AM, Paivarinta, E & Mutanen, M (2005) Promotion of adenoma growth by dietary inulin is associated with increase in cyclin D1 and decrease in adhesion proteins in Min/+ mice mucosa. J Nutr Biochem 16, 402–409.
5Näthke, IS (2004) The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium. Annu Rev Cell Dev Biol 20, 337–366.
6Cowin, P (1994) Unraveling the cytoplasmic interactions of the cadherin superfamily. Proc Natl Acad Sci U S A 91, 10759–10761.
7Shtutman, M, Zhurinsky, J, Simcha, I, Albanese, C, D'Amico, M, Pestell, R & Ben-Ze'ev, A (1999) The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A 96, 5522–5527.
8Tetsu, O & McCormick, F (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422–426.
9He, TC, Sparks, AB, Rago, C, Hermeking, H, Zawel, L, da Costa, LT, Morin, PJ, Vogelstein, B & Kinzler, KW (1998) Identification of c-MYC as a target of the APC pathway. Science 281, 1509–1512.
10Hao, X, Tomlinson, I, Ilyas, M, Palazzo, JP & Talbot, IC (1997) Reciprocity between membranous and nuclear expression of beta-catenin in colorectal tumours. Virchows Arch 431, 167–172.
11Herter, P, Kuhnen, C, Muller, KM, Wittinghofer, A & Muller, O (1999) Intracellular distribution of beta-catenin in colorectal adenomas, carcinomas and Peutz-Jeghers polyps. J Cancer Res Clin Oncol 125, 297–304.
12Brabletz, T, Herrmann, K, Jung, A, Faller, G & Kirchner, T (2000) Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas. Am J Pathol 156, 865–870.
13Cavallaro, U & Christofori, G (2004) Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 4, 118–132.
14Arber, N, Hibshoosh, H, Moss, SF, Sutter, T, Zhang, Y, Begg, M, Wang, S, Weinstein, IB & Holt, PR (1996) Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology 110, 669–674.
15Kristt, D, Turner, I, Koren, R, Ramadan, E & Gal, R (2000) Overexpression of cyclin D1 mRNA in colorectal carcinomas and relationship to clinicopathological features: an in situ hybridization analysis. Pathol Oncol Res 6, 65–70.
16Bartkova, J, Thullberg, M, Slezak, P, Jaramillo, E, Rubio, C, Thomassen, LH & Bartek, J (2001) Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon. Gastroenterology 120, 1680–1688.
17Utsunomiya, T, Doki, Y, Takemoto, H, Shiozaki, H, Yano, M, Sekimoto, M, Tamura, S, Yasuda, T, Fujiwara, Y & Monden, M (2001) Correlation of beta-catenin and cyclin D1 expression in colon cancers. Oncology 61, 226–233.
18Bahnassy, AA, Zekri, AR, El-Houssini, S, El-Shehaby, AM, Mahmoud, MR, Abdallah, S & El-Serafi, M (2004) Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients. BMC Gastroenterology 4, 22.
19Mermelshtein, A, Gerson, A, Walfisch, S, Delgado, B, Shechter-Maor, G, Delgado, J, Fich, A & Gheber, L (2005) Expression of D-type cyclins in colon cancer and in cell lines from colon carcinomas. Br J Cancer 93, 338–345.
20Zucker, S & Vacirca, J (2004) Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev 23, 101–117.
21Mook, OR, Frederiks, WM & Van Noorden, CJ (2004) The role of gelatinases in colorectal cancer progression and metastasis. Biochim Biophys Acta 1705, 69–89.
22Reeves, PG, Nielsen, FH & Fahey, GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 1939–1951.
23Luebeck, EG & Moolgavkar, SH (2002) Multistage carcinogenesis and the incidence of colorectal cancer. Proc Natl Acad Sci U S A 99, 15095–15100.
24Pool-Zobel, BL (2005) Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data. Br J Nutr 93, Suppl. 1, S73–S90.
25Takahashi, M & Wakabayashi, K (2004) Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci 95, 475–480.
26Song, J, Medline, A, Mason, JB, Gallinger, S & Kim, Y-I (2000) Effects of dietary folate on intestinal tumorigenesis in the ApcMin Mouse. Cancer Res 60, 5434–5440.
27O'Shaughnessy, JA, Kelloff, GJ, Gordon, GB, et al. (2002) Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development. Clin Cancer Res 8, 314–346.
28Rafter, J, Bennett, M, Caderni, G, et al. (2007) Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr 85, 488–496.
29Behrens, J (2005) The role of the Wnt signalling pathway in colorectal tumorigenesis. Biochem Soc Trans 33, 672–675.
30Zhang, T, Nanney, LB, Luongo, C, Lamps, L, Heppner, KJ, DuBois, RN & Beauchamp, RD (1997) Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res 57, 169–175.
31Sansom, OJ, Reed, KR, van de Wetering, M, Muncan, V, Winton, DJ, Clevers, H & Clarke, AR (2005) Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine. J Biol Chem 280, 28463–28467.
32Wilding, J, Straub, J, Bee, J, Churchman, M, Bodmer, W, Dickson, C, Tomlinson, I & Ilyas, M (2002) Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice. Cancer Res 62, 4562–4565.
33Hulit, J, Wang, C, Li, Z, et al. (2004) Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol Cell Biol 24, 7598–7611.
34Smits, R, Ruiz, P, Diaz-Cano, S, Luz, A, Jagmohan-Changur, S, Breukel, C, Birchmeier, C, Birchmeier, W & Fodde, R (2000) E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice. Gastroenterology 119, 1045–1053.
35Gottardi, CJ, Wong, E & Gumbiner, BM (2001) E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol 153, 1049–1060.
36Gottardi, CJ & Gumbiner, BM (2004) Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes. J Cell Biol 167, 339–349.
37Carothers, AM, Melstrom, KA Jr, Mueller, JD, Weyant, MJ & Bertagnolli, MM (2001) Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice. J Biol Chem 276, 39094–39102.
38Ju, J, Hong, J, Zhou, JN, et al. (2005) Inhibition of intestinal tumorigenesis in Apcmin/+ mice by ( − )-epigallocatechin-3-gallate, the major catechin in green tea. Cancer Res 65, 10623–10631.
39Hinck, L, Nelson, WJ & Papkoff, J (1994) Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin. J Cell Biol 124, 729–741.