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The influence of enzyme-resistant starch on cholesterol metabolism in rats fed on a conventional diet

Published online by Cambridge University Press:  09 March 2007

K. Vanhoof  and
R. De Schrijver
K. Vanhoof
Affiliation:
Laboratory of Nutrition, Catholic University of Leuven, Kard. Mercierlaan 92, 3001 Leuven, Belgium
R. De Schrijver*
Affiliation:
Laboratory of Nutrition, Catholic University of Leuven, Kard. Mercierlaan 92, 3001 Leuven, Belgium
*
*Corresponding author: Professor R. De Schrijver, fax +32 16 321971, email Remi.DeSchrijver@agr.kuleuven.ac.be
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Abstract

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Male Wistar rats were fed on a conventional diet containing normal corn starch or 6 % enzyme-resistant starch originating from either raw or retrograded high-amylose corn starch. Furthermore, the diets were either cholesterol-free or contained 1 % cholesterol and 0·1 % cholic acid. The main objective of this study was to investigate whether the addition of enzyme-resistant starch to a rat conventional diet had any effect on cholesterol metabolism. Therefore, plasma and liver cholesterol concentrations, plasma HDL:LDL cholesterol ratios and neutral steroid and bile acid excretion were determined. No significant effect of enzyme-resistant starch feeding on plasma and liver cholesterol concentrations was found. However, consumption of raw or retrograded high-amylose corn starch resulted in a decrease in esterified and total liver cholesterol concentrations of 24 and 22 %, respectively. This was accompanied by a reduction in plasma esterified and total cholesterol levels of 4 % and a tendency to higher daily faecal coprostanol and total bile acid excretion.

Keywords

Resistant starchCholesterol metabolismRats
Type
Research Article
Information
British Journal of Nutrition , Volume 80 , Issue 2 , February 1998 , pp. 193 - 198
Copyright
Copyright © The Nutrition Society 1998

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