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The influence of birth weight and genetic factors on lipid levels: a study in adult twins

  • Chuluuntulga Tuya (a1), William J. Mutch (a2), Paul Haggarty (a3), Doris M. Campbell (a4), Alastair Cumming (a5), Kevin Kelly (a6), Iain Broom (a2) and Geraldine McNeill (a7)...


Twins can be used to investigate the biological basis for observed associations between birth weight and later disease risk, as they experience in utero growth restriction compared with singletons, which can differ in magnitude within twin pairs despite partial or total genetic identity. In the present study, sixty monozygotic and seventy-one dizygotic same-sex twin pairs aged 19–50 years and eighty-nine singleton controls matched for age, gestational age, sex, maternal age and parity were recruited from an obstetric database. Associations between fasting lipid levels and birth weight were assessed by linear regression with adjustment for possible confounding factors. Twins were significantly lighter at birth but were not significantly different in adult height, weight or lipid levels from the singleton controls. There was a significant inverse association between birth weight and both total and LDL-cholesterol levels among singleton controls (−0·53mmol/l per kg (95% CI −0·97, −0·09), P=0·02 and −0·39mmol/l per kg (95% CI −0·76, −0·02), P=0·04, respectively), but there was no significant association between birth weight and lipid levels in either unpaired or within-pair analysis of twins. The results suggest that the in utero growth restriction and early catch-up growth experienced by twins does not increase the risk of an atherogenic lipid profile in adult life.

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Barker, DJ, Hales, CN, Fall, CH, Osmond, C, Phipps, K & Clark, PM 1993 Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36 6267.
Barker, DJP 1995 Fetal origins of coronary heart disease. BMJ 311 171174.
Barker, DJPMothers, Babies and Health in Later Life. Edinburgh: Churchill Livingstone 1998
Barker, DJP 1999 Fetal origins of cardiovascular disease. Ann Med 31 36.
Bo, S, Cavallo-Perin, P, Ciccone, G, Scaglione, L & Pagano, G 2001 The metabolic syndrome in twins: a consequence of low birth weight or of being a twin?. Exp Clin Endocrinol Diabetes 109 135140.
Boekholdt, SM, Kuivenhoven, JA, Hovingh, GK, Jukema, JW, Kastelein, JJ & van Tol, ACETP gene variation: relation to lipid parameters and cardiovascular risk. Review. Curr Opin Lipidol 2004 15 393398.
Bring, J & Wernroth, L 1999 Inefficient analysis of twin data: is there an association between diabetes and birth weight?. Diabetologia 42 898899.
Burke, JP, Forsgren, J, Palumbo, PJ, Bailey, KR, Desai, J, Devlin, H & Leibson, CL 2004 Association of birth weight and type 2 diabetes in Rochester, Minnesota. Diabetes Care 27 25122513.
Curhan, GC, Chertow, GM, Willett, WC, Spiegelman, D, Colditz, GA, Manson, JE, Speizer, FE & Stampfer, MJ 1996 Birth weight and adult hypertension and obesity in women. Circulation 94 13101315.
Eriksson, JG, Forsen, T, Tuomilehto, J, Winter, PD, Osmond, C & Barker, DJ 1999 Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ 318 427431.
Eriksson, JG, Lindi, VUusitupa, M, Forsen, TJ, Laakso, M, Osmond, C & Barker, DJ 2002 The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth. Diabetes 51 23212324.
Forsen, T, Eriksson, JG, Tuomilehto, J, Osmond, C & Barker, DJP 1999 Growth in utero and during childhood among women who develop coronary heart disease: longitudinal study. BMJ 319 14031407.
Friedewald, WT, Levy, RI & Fredrickson, DS 1972 Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18 499502.
Gluckman, PD & Hanson, MA 2004 Maternal constraint of fetal growth and its consequences. Review. Semin Fetal Neonatal Med 9 419425.
Hattersley, AT & Tooke, JE 1999 The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease. Lancet 353 17891792.
Huxley, R, Owen, CG, Whincup, PH, Cook, DG, Colman, S & Collins, R 2004 Birth weight and subsequent cholesterol levels: exploration of the “fetal origins” hypothesis. JAMA 292 27552764.
Huxley, RR, Shiell, AW &Law, CM 2000 The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature. J Hypertens 18 815831.
Ijzerman, RG, Stehouwer, CD, van Weissenbruch, MM, De Geus, EJ & Boomsma, DI 2001 Evidence for genetic factors explaining the association between birth weight and low-density lipoprotein cholesterol and possible intrauterine factors influencing the association between birth weight and high-density lipoprotein cholesterol: analysis in twins. J Clin Endocrinol Metab 86 54795484.
Kannel, WB & Sorlie, P 1979 Some health benefits of physical activity:the Framingham Heart Study. Arch Intern Med 139 857861.
Keet, MP, Jaroszewicz, AM & Lombard, CJ 1986 Follow-up study of physical growth of monozygous twins with discordant within-pair birth weights. Pediatrics 77 336344.
Laurén, L, Jarvelin, MR, Elliott, P et al. 2003 Relationship between birthweight and blood lipid concentrations in later life: evidence from the existing literature. Int J Epidemiol 32 862876.
Loos, RJ, Derom, C, Derom, R & Vlietinck, R 2005 Determinants of birthweight and intrauterine growth in liveborn twins. Paediatr Perinat Epidemiol 19 1522.
Lopiore, E, Nagel, HT, Vandenbussche, FR & Walther, FJ 2003 Long-term neurodevelopmental outcome in twin-to-twin transfusion syndrome. Am J Obstet Gynecol 189 13141319.
McMillen, IC & Robinson, JS 2005 Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Review. Physiol Rev 85 571633.
McNeill, G, Tuya, C, Campbell, DM, Haggarty, P, Smith, WC, Masson, LF, Cumming, A, Broom, I & Haites, N 2003 Blood pressure in relation to birth weight in twins and singleton controls matched for gestational age. Am J Epidemiol 158 150155.
Magnus, P 1984 Causes of variation in birth weight: a study of offspring of twins. Clin Genet 25 1524.
Magnus, P, Bakketeig, LS & Hoffman, HBirth weight of relatives by maternal tendency to repeat small-for-gestational-age (SGA) births in successive pregnancies. Acta Obstet Gynecol Scand 1997 165 Suppl.3538.
Martin, RM, Ben-Shlomo, Y, Gunnell, D, Elwood, P, Yarnell, JW & Davey, Smith G 2005 Breast feeding and cardiovascular disease risk factors, incidence, and mortality: the Caerphilly study. J Epidemiol Community Health 59 121129.
Masson, LF, McNeill, G, Tomany, JO, Simpson, JA, Peace, HS, Wei, L, Grubb, DA & Bolton-Smith, C 2003 Statistical approaches for assessing the relative validity of a food frequency questionnaire: use of correlation coefficients and the kappa statistic. Public Health Nutr 6 313321.
Neale, MC, Boker, SM, Xie, G & Maes, HHMx: Statistical Modeling 6th edition. Richmond, VA: Virginia Commonwealth University, Department of Psychiatry 2004
Owen, CG, Whincup, PH, Odoki, K, Gilg, JA & Cook, DG 2003 Birth weight and blood cholesterol level: a study in adolescents and systematic review. Pediatrics 111 10811089.
Phillips, DI, Davies, MJ & Robinson, JS 2001 Fetal growth and the fetal origins hypothesis in twins – problems and perspectives. Twin Res 4 327331.
Poulter, NHeart. Global risk of cardiovascular disease Suppl. 2ii2–ii5, ii35–ii37. 2003 89
Purcell, S 2000 Behavioural Genetic Interactive Modules.
Rich-Edwards, JW, Colditz, GA, Stampfer, MJ, Willett, WC, Gillman, MW, Hennekens, CH, Speizer, FE & Manson, JE 1999 Birthweight and the risk for type 2 diabetes mellitus in adult women. Ann Intern Med 130 278284.
Rich-Edwards, JW, Stampfer, MJ, Manson, JE, Rosner, B, Hankinson, SE, Colditz, GA, Willett, WC & Hennekens, CH 1997 Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976. BMJ 315 396400.
Smith, WCS, Tunstall-Pedoe, H, Crombie, IK & Tavendale, R 1989 Concomitants of excess coronary deaths – major risk factor and lifestyle findings from 10, 359 men and women in Scottish Heart Health Study. Scot Med J 34 550555.
Stein, CE, Fall, CH, Kumaran, K, Osmond, C, Cox, V & Barker, DJ 1996 Fetal growth and coronary heart disease in south India. Lancet 348 12691273.
Tuya, C, Mutch, W, Broom, J, Campbell, DM & McNeill, G 2003 Size at birth, fasting glucose and insulin levels and insulin resistance in adult twins. Twin Res 6 302306.
Tuya, C, Mutch, WJ, Broom, I & McNeill, G 2005 The effect of birth weight on clottable and intact fibrinogen levels: a twin study. J Thromb Haemost 3 11431148.



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