1Pérez-Cano, FJ, Castellote, C, González-Castro, AM, et al. (2005) Developmental changes in intraepithelial T lymphocytes and NK cells in the small intestine of neonatal rats. Pediatr Res 58, 885–891.
2Pérez-Cano, FJ, Castellote, C, Marín-Gallén, S, et al. (2005) Neonatal immunoglobulin secretion and lymphocyte phenotype in rat small intestine lamina propria. Pediatr Res 58, 164–169.
3Pérez-Cano, FJ, Marín-Gallén, S, Castell, M, et al. (2007) Bovine whey protein concentrate supplementation modulates maturation of immune system in suckling rats. Br J Nutr 98, Suppl. 1, S80–S84.
4Lönnerdal, B (2003) Nutritional and physiologic significance of human milk proteins. Am J Clin Nutr 77, 1537S–1543S.
5Field, CJ (2005) The immunological components of human milk and their effect on immune development in infants. J Nutr 135, 1–4.
6Kelly, D & Coutts, AG (2000) Early nutrition and the development of immune function in the neonate. Proc Nutr Soc 59, 177–185.
7Gil, A & Rueda, R (2002) Interaction of early diet and the development of the immune system. Nutr Res Rev 15, 263–292.
8Field, CJ, Clandinin, MT & Van Aerde, JE (2001) Polyunsaturated fatty acids and T-cell function: implications for the neonate. Lipids 36, 1025–1032.
9Mcguire, MK, Park, Y, Behre, RA, et al. (1997) Conjugated linoleic acid concentrations of human milk and infant formula. Nutr Res 17, 1277–1283.
10Jensen, RG & Lammi-Keefe, C (2001) The anticarcinogenic conjugated fatty acid c9, t11-c18:2, or rumenic acid, in human milk: amounts and effects. Adv Exp Med Biol 501, 153–156.
11Luna, P, Juarez, M & Angel de la Fuente, M (2007) Fatty acid and conjugated linoleic acid isomer profiles in human milk fat. Eur J Lipid Sci Technol 109, 1160–1166.
12Chin, SF, Storkson, JM, Albright, KJ, et al. (1994) Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. J Nutr 124, 2344–2349.
13Ha, YL, Grimm, NK & Pariza, MW (1987) Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. Carcinogenesis 8, 1881–1887.
14Hayashi, AA, de Medeiros, SR, Carvalho, MH, et al. (2007) Conjugated linoleic acid (CLA) effects on pups growth, milk composition and lipogenic enzymes in lactating rats. J Dairy Res 74, 160–166.
15Kelley, NS, Hubbard, NE & Erickson, KL (2007) Conjugated linoleic acid isomers and cancer. J Nutr 137, 2599–2607.
16Nicolosi, RJ, Rogers, EJ, Kritchevsky, D, et al. (1997) Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery 22, 266–277.
17Taylor, CG & Zahradka, P (2004) Dietary conjugated linoleic acid and insulin sensitivity and resistance in rodent models. Am J Clin Nutr 79, Suppl., 1164S–1168S.
18Park, Y & Pariza, MW (2007) Mechanisms of body fat modulation by conjugated linoleic acid (CLA). Food Res Int 40, 311–323.
19Kelley, DS, Warren, JM, Simon, VA, et al. (2002) Similar effects of c9,t11-CLA and t10,c12-CLA on immune cell functions in mice. Lipids 37, 725–728.
20O'Shea, M, Bassaganya-Riera, J & Mohede, IC (2004) Immunomodulatory properties of conjugated linoleic acid. Am J Clin Nutr 79, Suppl., 1199S–1206S.
21Wahle, KW, Heys, SD & Rotondo, D (2004) Conjugated linoleic acids: are they beneficial or detrimental to health? Prog Lipid Res 43, 553–587.
22Bhattacharya, A, Banu, J, Rahman, M, et al. (2006) Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem 17, 789–810.
23Pariza, MW, Park, Y & Cook, ME (2001) The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 40, 283–298.
24Storkson, JM, Park, Y, Cook, ME, et al. (2005) Effects of trans-10, cis-12 conjugated linoleic acid (CLA) and cognates on apolipoprotein B secretion in HepG2 cells. Nutr Res 25, 387–389.
25Moloney, F, Toomey, S, Noone, E, et al. (2007) Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes 56, 574–582.
26Bassaganya-Riera, J, Reynolds, K, Martino-Catt, S, et al. (2004) Activation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology 127, 777–791.
27Frazier, AL, Ryan, CT, Rockett, H, et al. (2003) Adolescent diet and risk of breast cancer. Breast Cancer Res 5, R59–R64.
28Novelli, EL, Diniz, YS, Galhardi, CM, et al. (2007) Anthropometrical parameters and markers of obesity in rats. Lab Anim 41, 111–119.
29Reeves, PG, Nielsen, FH & Fahey, GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 1939–1951.
30Bondía-Pons, I, Moltó-Puigmartí, C, Castellote, AI, et al. (2007) Determination of conjugated linoleic acid in human plasma by fast gas chromatography. J Chromatogr A 1157, 422–429.
31Ringseis, R, Saal, D, Muller, A, et al. (2004) Dietary conjugated linoleic acids lower the triacylglycerol concentration in the milk of lactating rats and impair the growth and increase the mortality of their suckling pups. J Nutr 134, 3327–3334.
32Terpstra, AH (2004) Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. Am J Clin Nutr 79, 352–361.
33Poulos, SP, Sisk, M, Hausman, DB, et al. (2001) Pre- and postnatal dietary conjugated linoleic acid alters adipose development, body weight gain and body composition in Sprague–Dawley rats. J Nutr 131, 2722–2731.
34Schmid, A, Collomb, M, Bee, G, et al. (2008) Effect of dietary alpine butter rich in conjugated linoleic acid on milk fat composition of lactating sows. Br J Nutr 100, 54–60.
35Scimeca, JA (1998) Toxicological evaluation of dietary conjugated linoleic acid in male Fischer 344 rats. Food Chem Toxicol 36, 391–395.
36Park, Y, Albright, KJ & Pariza, MW (2005) Effects of conjugated linoleic acid on long term feeding in Fischer 344 rats. Food Chem Toxicol 43, 1273–1279.
37Pariza, MW (2004) Perspective on the safety and effectiveness of conjugated linoleic acid. Am J Clin Nutr 79, Suppl., 1132S–1136S.
38Yamasaki, M, Nishida, E, Nou, S, et al. (2005) Cytotoxity of the trans10, cis12 isomer of conjugated linoleic acid on rat hepatoma and its modulation by other fatty acids, tocopherol, and tocotrienol. In Vitro Cell Dev Biol Anim 41, 239–244.
39Tricon, S, Burdge, GC, Williams, CM, et al. (2005) The effects of conjugated linoleic acid on human health-related outcomes. Proc Nutr Soc 64, 171–182.
40Gómez-Candela, C (2004) El papel del CLA o ácido linoleico conjugado sobre la masa grasa corporal (The role of CLA or conjugated linoleic acid on body fat mass). Nutr Diet 1, 75–83.
41Schram, LB, Nielsen, CJ, Porsgaard, T, et al. (2007) Food matrices affect the bioavailability of (n-3) polyunsaturated fatty acids in a single meal study in humans. Food Res Int 40, 1062–1068.
42Bowen, RAR & Clandinin, MT (2005) Maternal dietary 22 : 6n-3 is more effective than 18 : 3n-3 in increasing the 22 : 6n-3 content in phospholipids of glial cells from neonatal rat brain. Br J Nutr 93, 601–611.
43Macarulla, MT, Fernandez-Quintela, A, Zabala, A, et al. (2005) Effects of conjugated linoleic acid on liver composition and fatty acid oxidation are isomer-dependent in hamster. Nutrition 21, 512–519.
44Kavanaugh, CJ, Liu, KL & Belury, MA (1999) Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. Nutr Cancer 33, 132–138.
45Chin, SF, Storkson, JM, Liu, W, et al. (1994) Conjugated linoleic acid (9,11- and 10,12-octadecadienoic acid) is produced in conventional but not germ-free rats fed linoleic acid. J Nutr 124, 694–701.
46Santora, JE, Palmquist, DL & Roehrig, KL (2000) Trans-vaccenic acid is desaturated to conjugated linoleic acid in mice. J Nutr 130, 208–215.
47Dahlgren, UI, Ahlstedt, S & Hanson, LA (1986) Origin and kinetics of IgA, IgG and IgM milk antibodies in primary and secondary responses of rats. Scand J Immunol 23, 273–278.
48Redman, DR (1979) Prenatal influence of immunocompetence of the neonate. J Anim Sci 49, 258–267.
49Sugano, M, Tsujita, A, Yamasaki, M, et al. (1998) Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats. Lipids 33, 521–527.
50Song, HJ, Grant, I, Rotondo, D, et al. (2005) Effect of CLA supplementation on immune function in young healthy volunteers. Eur J Clin Nutr 59, 508–517.
51Yamasaki, M, Kishihara, K, Mansho, K, et al. (2000) Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague–Dawley rat spleen lymphocytes. Biosci Biotechnol Biochem 64, 2159–2164.
52Bontempo, V, Sciannimanico, D, Pastorelli, G, et al. (2004) Dietary conjugated linoleic acid positively affects immunologic variables in lactating sows and piglets. J Nutr 134, 817–824.
53Rossi, R, Pastorelli, G, Bontempo, V, et al. (2004) Effects of dietary conjugated linoleic acid (CLA) on immunoglobulin concentration in sow colostrum and piglet serum. Vet Res Commun 28, Suppl. 1, 241–244.
54Turpeinen, AM, Ylonen, N, von Willebrand, E, et al. (2008) Immunological and metabolic effects of cis-9, trans-11-conjugated linoleic acid in subjects with birch pollen allergy. Br J Nutr 100, 112–119.
55Brandtzaeg, P & Johansen, FE (2005) Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties. Immunol Rev 206, 32–63.
56Pérez-Cano, FJ, Ramírez-Santana, C, Molero-Luís, M, et al. (2009) Mucosal IgA increase in rats by continuous CLA feeding during suckling and early infancy. J Lipid Res 50, 467–476.
57Ramirez-Santana, C, Castellote, C, Castell, M, et al. (2009) Long-term feeding of the cis-9, trans-11 isomer of conjugated linoleic acid reinforces the specific immune response in rats. J Nutr 139, 76–81.
58Yamasaki, M, Chujo, H, Hirao, A, et al. (2003) Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid. J Nutr 133, 784–788.
59Pérez-Cano, FJ, Castellote, C, Marín-Gallén, S, et al. (2007) Phenotypic and functional characteristics of rat spleen lymphocytes during suckling. Dev Comp Immunol 31, 1264–1277.
60Calder, PC, Yaqoob, P, Thies, F, et al. (2002) Fatty acids and lymphocyte functions. Br J Nutr 87, Suppl. 1, S31–S48.
61Nunes, EA, Bonatto, SJ, de Oliveira, HH, et al. (2008) The effect of dietary supplementation with 9-cis:12-trans and 10-trans: 12-cis conjugated linoleic acid (CLA) for nine months on serum cholesterol, lymphocyte proliferation and polymorphonuclear cells function in Beagle dogs. Res Vet Sci 84, 62–67.
62Tricon, S, Burdge, GC, Kew, S, et al. (2004) Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid on immune cell function in healthy humans. Am J Clin Nutr 80, 1626–1633.
63Albers, R, van der Wielen, RP, Brink, EJ, et al. (2003) Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. Eur J Clin Nutr 57, 595–603.
64Kelley, DS & Erickson, KL (2003) Modulation of body composition and immune cell functions by conjugated linoleic acid in humans and animal models: benefits vs. risks. Lipids 38, 377–386.
65Yang, M & Cook, ME (2002) Dietary conjugated linoleic acid decreased cachexia, macrophage tumor necrosis factor-α production, and modifies splenocyte cytokines production. Exp Biol Med 228, 51–58.
66Hayek, MG, Han, SN, Wu, D, et al. (1999) Dietary conjugated linoleic acid influences the immune response of young and old C57BL/6NCrlBR mice. J Nutr 129, 32–38.
67Turpeinen, AM, von Willebrand, E, Salminen, I, et al. (2006) Effects of cis-9, trans-11 CLA in rats at intake levels reported for breast-fed infants. Lipids 41, 669–677.
68Loscher, CE, Draper, E, Leavy, O, et al. (2005) Conjugated linoleic acid suppresses NF-κB activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction. J Immunol 175, 4990–4998.
69Bergamo, P, Maurano, F, D'Arienzo, R, et al. (2008) Association between activation of phase 2 enzymes and down-regulation of dendritic cell maturation by c9,t11-conjugated linoleic acid. Immunol Lett 117, 181–190.