Hostname: page-component-848d4c4894-tn8tq Total loading time: 0 Render date: 2024-07-04T05:38:15.606Z Has data issue: false hasContentIssue false
  • English
  • Français

Haematological and tissue abnormalities in chicks caused by acute and subclinical folate deficiency

Published online by Cambridge University Press:  09 March 2007

M. H. Maxwell ,
C. C. Whitehead  and
J. Armstrong
M. H. Maxwell
Affiliation:
AFRC Institute for Grassland and Animal Production, Poultry Division, Roslin, Midlothian EH25 9PS
C. C. Whitehead
Affiliation:
AFRC Institute for Grassland and Animal Production, Poultry Division, Roslin, Midlothian EH25 9PS
J. Armstrong
Affiliation:
AFRC Institute for Grassland and Animal Production, Poultry Division, Roslin, Midlothian EH25 9PS
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Haematological, histological and ultrastructural findings in young chicks fed on a purified diet severely deficient in folate are reported.

2. Growth of the birds was greatly depressed and they had a macrocytic anaemia. Other haematological changes included abnormal nuclear formations in erythrocytes, numerous mitoses and hypersegmented granulocytes.

3. Megaloblasts were observed in bone marrow and their fine structure is described for the first time in an avian species.

4. Morphological changes occurred also in the liver. The parenchyma had damaged sinusoidal endothelium, inflammatory cells and no glycogen. Mitochondria were damaged and many were associated with unusual crystalline structures.

5. Chickens fed on a semi-purified diet of low folate content showed no growth depression or clinical signs of deficiency but had abnormal haematological values and morphological changes that resembled those seen in birds fed on the purified diet.

6. These abnormalities responded to dietary supplements of pteroylmonoglutamic acid in a dose-related manner and may be useful in diagnosing subclinical folate deficiency.

Type
General Nutrition papers
Information
British Journal of Nutrition , Volume 59 , Issue 1 , January 1988 , pp. 73 - 80
Copyright
Copyright © The Nutrition Society 1988

References

Bessis, M. (1973). Living Blood Cells and their Ultrastructure, pp. 252–260. Berlin: Springer-Verlag.Google Scholar
Campbell, C. J., McCabe, M. M., Brown, R. A. & Emmett, A. D. (1945). American Journal of Physiology 144, 348–354.CrossRefGoogle Scholar
Coates, V. & March, B. E. (1966). Poultry Science 45, 1302–1305.CrossRefGoogle Scholar
Ericsson, J. L. E., Orrenius, S. & Holm, I. (1966). Experimental and Molecular Pathology 5, 329–349.CrossRefGoogle Scholar
Ghadially, G. N. (1982). Ultrastructural Pathology of the Cell and Matrix, 2nd ed., pp. 240–245. London: Butterworths.Google Scholar
Hogan, A. G. & Parrott, E. M. (1940). Journal of Biological Chemistry 132, 507–517.CrossRefGoogle Scholar
Ito, K., Ito, N., Sato, S. & Katsunuma, H. (1964). Acta Haematologica Japonica 27, 436–442.Google Scholar
Maxwell, M. H. (1978). Medical Laboratory Sciences 35, 401–403.Google Scholar
Maxwell, M. H. (1981). Research in Veterinary Science 30, 233–238.CrossRefGoogle Scholar
National Research Council (1984). Nutrient Requirements of Poultry, 8th ed. Washington DC: National Academy Press.Google Scholar
Schalm, O. W., Jain, H. C. & Carroll, E. J. (1975). Veterinary Hematology, 3rd ed. Philadelphia: Lea & Febiger.Google Scholar
Waxman, S., Schreiber, C. (1980). Methods in Enzymology 6E, 468–483.CrossRefGoogle Scholar
Wickramasinghe, S. N. & Bush, V. (1977). Acta Haematologica 57, 1–14.CrossRefGoogle Scholar
Wintrobe, M. M., Lea, G. R., Boggs, D. R., Bithell, T. C., Foerster, J., Athens, J. W. & Lukens, J. N. (1981). Clinical Hematology, 8th ed. pp. 151, 559–597, 617–643. Philadelphia: Lea and Febiger.Google Scholar
Zucker-Franklin, D., Greaves, M. F., Grossi, C. E. & Marmont, A. M. (1981). Atlas of Blood Cells: Function and Pathology, vol. 1, pp. 75–82. Milan, Italy: Edi. Ermes.Google Scholar