Ahima, RS & Osei, SYMolecular regulation of eating behavior:new insights and prospects for therapeutic strategies. Trends Mol Med (2001) 7, 205–213.
Al Awar, R, Obeid, O, Hwalla, N & Azar, SPostprandial acylated ghrelin status following fat and protein manipulation of meals in healthy young women. Clin Sci (2005) 109, 405–411.
Andersson, U, Filipsson, K, Abbott, CR, Woods, A, Smith, K, Bloom, SR, Carling, D & Small, CJAMP-activated protein kinase plays a role in the control of food intake. J Biol Chem (2004) 279, 12005–12008.
Ariyasu, H, Takaya, K, Hosoda, H et al. Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin. Endocrinology (2002) 143, 3341–3350.
Ariyasu, H, Takaya, K, Iwakura, H, Hosoda, H, Akamizu, T, Arai, Y, Kangawa, K & Nakao, KTransgenic mice overexpressing des-acyl ghrelin show small phenotype. Endocrinology (2005) 146, 355–364.
Arvat, E, Di Vito, L, Broglio, F, Papotti, M, Muccioli, G, Dieguez, C, Casanueva, FF, Deghenghi, R, Camanni, F & Ghigo, EPreliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest (2000) 23, 493–495.
Asakawa, A, Inui, A, Fujimiya, M, Sakamaki, R, Shinfuku, N, Ueta, Y, Meguid, MM & Kasuga, MStomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut (2005) 54, 18–24.
Asakawa, A, Inui, A, Kaga, T, Katsuura, G, Fujimiya, M, Fujino, MA & Kasuga, MAntagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut (2003) 52, 947–952.
Asakawa, A, Inui, A, Kaga, T et al. Ghrelin is an appetitestimulatory signal from stomach with structural resemblance to motilin. Gastroenterology (2001) 120, 337–345.
Atrens, DM, Sinden, JD, Penicaud, L, Devos, M & Le Magnen, JHypothalamic modulation of energy expenditure. Physiol Behav (1985) 35, 15–20.
Bacha, F & Arslanian, SAGhrelin suppression in overweight children: a manifestation of insulin resistance? J Clin Endocrinol Metab (2005) 90, 2725–2730.
Bagnasco, M, Dube, MG, Kalra, PS & Kalra, SPEvidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic sitespecific leptin gene therapy. Endocrinology (2002) 143, 4409–4421.
Bagnasco, M, Tulipano, G, Melis, MR, Argiolas, A, Cocchi, D & Muller, EEEndogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting. Regul Pept (2003) 111, 161–167.
Baile, CA, Della-Fera, MA & Martin, RJRegulation of metabolism and body fat mass by leptin. Annu Rev Nutr (2000) 20, 105–127.
Baldanzi, G, Filigheddu, N, Cutrupi, S et al. Ghrelin and desacyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol (2002) 159, 1029–1037.
Barazzoni, R, Bosutti, A, Stebel, M, Cattin, MR, Roder, E, Visintin, L, Cattin, L, Biolo, G, Zanetti, M & Guarnieri, GGhrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle. Am J Physiol (2005) 288, E228–E235.
Barazzoni, R, Zanetti, M, Stebel, M, Biolo, G, Cattin, L & Guarnieri, GHyperleptinemia prevents increased plasma ghrelin concentration during short-term moderate caloric restriction in rats. Gastroenterology (2003) 124, 1188–1192.
Barkan, AL, Dimaraki, EV, Jessup, SK, Symons, KV, Ermolenko, M & Jaffe, CAGhrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. J Clin Endocrinol Metab (2003) 88, 2180–2184.
Batterham, RL, Cowley, MA, Small, CJ et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature (2002) 418, 650–654.
Beaumont, NJ, Skinner, VO, Tan, TM et al. Ghrelin can bind to a species of high-density lipoprotein associated with paraoxonase. J Biol Chem (2003) 278, 8877–8880.
Bedendi, I, Alloatti, G, Marcantoni, A, Malan, D, Catapano, F, Ghe, C, Deghenghi, R, Ghigo, E & Muccioli, GCardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin. Eur J Pharmacol (2003) 476, 87–95.
Bednarek, MA, Feighner, SD, Pong, SS, McKee, KK, Hreniuk, DL, Silva, MV, Warren, VA, Howard, ADVan Der Ploeg, LH & Heck, JVStructure–function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem (2000) 43 4370–4376
Beg, ZH, Allmann, DW & Gibson, DMModulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and with protein fractions of rat liver cytosol. Biochem Biophys Res Commun (1973) 54, 1362–1369.
Bercu, BB & Walker, RFNovel growth hormone secretagogues: clinical applications. Endocrinologist (1997) 7, 51–64.
Bing, C, Ambye, L, Fenger, M, Jorgensen, T, Borch-Johnsen, K, Madsbad, S & Urhammer, SALarge-scale studies of the Leu72Met polymorphism of the ghrelin gene in relation to the metabolic syndrome and associated quantitative traits. Diabet Med (2005) 22, 1157–1160.
Bowers, CYUnnatural growth hormone-releasing peptide begets natural ghrelin. J Clin Endocrinol Metab (2001) 8, 1464–1469.
Bowers, CY, Chang, J, Momany, FA & Folkers, KEffects of the enkephalins and enkephalin-analog on release of pituitary hormones in vitro. Proceedings of the 6th International Conference on Endocrinology, Molecular Endocrinology. In, [MacIntyre, I]. Amsterdam: Elsevier. (1977) 287
Broberger, C, Landry, M, Wong, H, Walsh, JN & Hokfelt, TSubtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology (1997) 66 393–408
Broglio, F, Arvat, E, Benso, A, Gottero, C, Muccioli, G, Papotti, M, van der Lely, AJ, Deghenghi, R & Ghigo, EGhrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab (2001) 86 5083–5086
Broglio, F, Gottero, C, Prodam, F, Gauna, C, Muccioli, G, Papotti, M, Abribat, T, van der Lely, AJ & Ghigo, ENon-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans. J Clin Endocrinol Metab (2004) 89 3062–3065
Broglio, F, Koetsveld, PP, Benso, Aet al. Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans. J Clin Endocrinol Metab (2002) 87 4829–4832
Callahan, HS, Cummings, DE, Pepe, MS, Breen, PA, Matthys, CC & Weigle, DSPostprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans. J Clin Endocrinol Metab (2004) 89 1319–1324
Carlson, CA & Kim, KHRegulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation. J Biol Chem (1973) 248 378–380
Casanueva, FF & Diéguez, CGhrelin: the link connecting growth with metabolism and energy homeostasis. Rev Endocr Metab Disord (2002) 3 325–338
Cassoni, P, Ghe, C, Marrocco, T, Tarabra, E, Allia, E, Catapano, F, Deghenghi, R, Ghigo, E, Papotti, M & Muccioli, GExpression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur J Endocrinol (2004) 150 173–184
Chan, CB & Cheng, CHIdentification and functional characterization of two alternatively spliced growth hormone secretagogue receptor transcripts from the pituitary of black seabream Acanthopagrus schlegeli. Mol Cell Endocrinol (2004) 214 81–95
Chanoine, JP & Wong, ACGhrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: effect of maternal fasting. Endocrinology (2004) 145 3813–3820
Chen, CY, Chao, Y, Chang, FY, Chien, EJ, Lee, SD & Doong, MLIntracisternal des-acyl ghrelin inhibits food intake and non-nutrient gastric emptying in conscious rats. Int J Mol Med (2005 a) 16 695–699
Chen, CY, Inui, A, Asakawa, A, Fujino, K, Kato, I, Chen, CC, Ueno, N & Fujimiya, MDes-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology (2005 b) 129 8–25
Chen, HY, Trumbauer, ME, Chen, ASet al. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agoutirelated protein. Endocrinology (2004) 145 2607–2612
Cone, RDThe central melanocortin system and energy homeostasis. Trends Endocrinol Metab (1999) 10 211–216
Cone, RDAnatomy and regulation of the central melanocortin system. Nature Neurosci (2005) 8 571–578
Corbetta, S, Peracchi, M, Cappiello, V, Lania, A, Lauri, E, Vago, L, Beck-Peccoz, P & Spada, ACirculating ghrelin levels inpatients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. J Clin Endocrinol Metab (2003) 88 3117–3120
Cowley, MA, Smith, RG, Diano, Set al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron (2003) 37 649–661
Culmsee, C, Monnig, J, Kemp, BE & Mattson, MPAMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J Mol Neurosci (2001) 17 45–58
Cummings, DE & Foster, KEGhrelin–leptin tango in bodyweight regulation. Gastroenterology (2003) 124 1532–1535
Cummings, DE, Foster-Schubert, KE & Overduin, JGhrelin and energy balance: focus on current controversies. Curr Drug Targets (2005) 6 153–169
Cummings, DE, Purnell, JQ, Frayo, RS, Schmidova, K, Wisse, BE & Weigle, DSpreprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes (2001) 50 1714–1719
Cummings, DE & Shannon, MHGhrelin and gastric bypass: is there a hormonal contribution to surgical weight loss? J Clin Endocrinol Metab (2003) 88 2999–3002
Cummings, DE, Weigle, DS, Frayo, RS, Breen, PA, Ma, MK, Dellinger, EP & Purnell, JQPlasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. New Eng J Med (2002) 346 1623–1630
Date, Y, Kojima, M, Hosoda, H, Sawaguchi, A, Mondal, MS, Suganuma, T, Matsukura, S, Kangawa, K & Nakazato, MGhrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology (2000) 141 4255–4261
Date, Y, Murakami, N, Toshinai, K, Matsukura, S, Niijima, A, Matsuo, H, Kangawa, K & Nakazato, MThe role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology (2002) 123 1120–1128
Date, Y, Nakazato, M, Murakami, N, Kojima, M, Kangawa, K & Matsukura, SGhrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun (2001) 280 904–907
Davis, JD, Wirtshafter, D, Asin, KE & Brief, DSustained intracerebroventricular infusion of brain fuels reduces body weight and food intake in rats. Science (1981) 212 81–83
De Smet, B, Depoortere, I, Moechars, D, Swennen, Q, Moreaux, B, Cryns, K, Tack, J, Buyse, JCoulie, B & Peeters, TLEnergy homeostasis and gastric emptying in ghrelin knockout mice. J Pharmacol Exp Ther (2006) 316 431–439
De Vriese, C, Gregoire, F, Lema-Kisoka, R, Waelbroeck, M, Robberecht, P & Delporte, CGhrelin degradation by serum and tissue homogenates: identification of the cleavage sites. Endocrinology (2004) 145 4997–5005
Del Rincón, JP, Thorner, MO & Gaylinn, BGMotilin-related peptide and ghrelin: lessons from molecular techniques, peptide chemistry, and receptor biology. Gastroenterology (2001) 120 587–588
Dixit, VD, Schaffer, EM, Pyle, RS, Collins, GD, Sakthivel, SK, Palaniappan, R, Lillard, JW Jr & Taub, DDGhrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest (2004) 114 57–66
Dockray, GLLuminal sensing in the gut; an overview. J Physiol Pharmacol (2003) 54 suppl. 4, 9–18
Druce, MR, Neary, NM, Small, CJ, Milton, J, Monteiro, M, Patterson, M, Ghatei, MA & Bloom, SRSubcutaneous administration of ghrelin stimulates energy intake in healthy lean human volunteers. Int J Obes (Lond) (2006) 30 293–296
Druce, MR, Small, CJ & Bloom, SRMinireview: gut peptides regulating satiety. Endocrinology (2004) 145 2660–2665
Egido, EM, Rodriguez-Gallardo, J, Silvestre, RA & Marco, JInhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion. Eur J Endocrinol (2002) 146 241–244
Eisenstein, J & Greenberg, AGhrelin: update 2003. Nutr Rev (2003) 61 101–104
English, PJ, Ghatei, MA, Malik, IA, Bloom, SR & Wilding, JPFood fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab (2002) 87 2984–2987
Erdmann, J, Topsch, R, Lippl, F, Gussmann, P & Schusdziarra, VPostprandial response of plasma ghrelin levels to various test meals in relation to food intake, plasma insulin, and glucose. J Clin Endocrinol Metab (2004) 89 3048–3054
Flanagan, DE, Evans, ML, Monsod, TP, Rife, F, Heptulla, RA, Tamborlane, WV & Sherwin, RSThe influence of insulin on circulating ghrelin. Am J Physiol (2003) 284 E313–E316
Gauna, C, Delhanty, PJ, Hofland, LJ, Janssen, JA, Broglio, F, Ross, RJ, Ghigo, E & van der Lely, AJGhrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes. J Clin Endocrinol Metab (2005) 90 1055–1060
Gauna, C, Meyler, FM, Janssen, JA, Delhanty, PJ, Abribat, T, van Koetsveld, P, Hofland, LJ, Broglio, F, Ghigo, E & van der Lely, AJAdministration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity. J Clin Endocrinol Metab (2004) 89 5035–5042
Gaytan, F, Barreiro, ML, Caminos, JEet al. Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors. J Clin Endocrinol Metab (2004) 89 400–409
Ghigo, E, Arvat, E, Giordano, Ret al. Biologic activities of growth hormone secretagogues in humans. Endocrine (2001) 14 87–93
Ghigo, E, Broglio, F, Arvat, E, Maccario, M, Papotti, M & Muccioli, GGhrelin: more than a natural GH secretagogue and/or an orexigenic factor. Clin Endocrinol (Oxf) (2005) 62 1–17
Gil, M, Villada, I, Aguilera, C, Linde, J, Ramírez-Tortosa, C, Cañete, R & Gil, APrepubertal obese children exhibit an altered postprandial plasma ghrelin pattern. Int J Obes (2004) 28 suppl. 1, 194
Gil-Campos, M Relaciones entre parámetros antropométricos, ingesta de nutrientes, hormonas y lípidos plasmáticos en niños obesos (Relationships between anthropometric parameters, nutrient intake, hormones and plasma lipids in obese children). PhD Thesis, University of Cordoba (2004)
Gil-Campos, M, Cañete, R & Gil, AHormones regulating lipid metabolism and plasma lipids in childhood obesity. Int J Obes Relat Metab Disord (2004 a) 28 S75–S80
Gil-Campos, M, Cañete, R & Gil, AAdiponectin, the missing link in insulin resistance and obesity. Clin Nutr (2004 b) 23 963–974
Giustina, A, Bonfanti, C, Licini, M, Ragni, G & Stefana, BHexarelin, a novel GHRP-6 analog, stimulates growth hormone (GH)release in a GH-secreting rat cell line (GH1) insensitive to GHreleasing hormone. Regul Pept (1997) 70 49–54
Gnanapavan, S, Kola, B, Bustin, SA, Morris, DG, McGee, P, Fairclough, P, Bhattacharya, S, Carpenter, R, Grossman, AB & Korbonits, MThe tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab (2002) 87 2988–2991
Gropp, E, Shanabrough, M, Borok, Eet al. Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci (2005) 8 1289–1291
Grove, KL & Cowley, MAIs ghrelin a signal for the development of metabolic systems? J Clin Invest (2005) 115 3393–3397
Guan, XM, Yu, H, Palyha, OC, McKee, KK, Feighner, SD, Sirinathsinghji, DJ, Smith, RG, Van der Ploeg, LH & Howard, ADDistribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res (1997) 48 23–29
Hahn, TM, Breininger, JF, Baskin, DG & Schwartz, MWCoexpression of AgRP and NPY in fasting-activated hypothalamic neurons. Nat Neurosci (1998) 1 271–272
Halem, HA, Taylor, JE, Dong, JZet al. Novel analogs of ghrelin:physiological and clinical implications. Eur J Endocrinol (2004) 151 suppl. 1, S71–S75
Halem, HA, Taylor, JE, Dong, JZ, Shen, Y, Datta, R, Abizaid, A, Diano, S, Horvath, TL & Culler, MDA novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain. Neuroendocrinology (2005) 81 339–349
Haqq, AM, Farooqi, IS, O'Rahilly, S, Stadler, DD, Rosenfeld, RG, Pratt, KL, LaFranchi, SH & Purnell, JQSerum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader–Willi syndrome. J Clin Endocrinol Metab (2003) 88 174–178
Hardie, DG, Salt, IP, Hawley, SA & Davies, SPAMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge. Biochem J (1999) 338 717–722
Haskell-Luevano, C, Chen, P, Li, C, Chang, K, Smith, MS, Cameron, JL & Cone, RDCharacterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat. Endocrinology (1999) 140 1408–1415
Heller, RS, Jenny, M, Collombat, P, Mansouri, A, Tomasetto, C, Madsen, OD, Mellitzer, G, Gradwohl, G & Serup, PGenetic determinants of pancreatic epsilon-cell development. Dev Biol (2005) 28 217–224
Hewson, AK & Dickson, SLSystemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats. J Neuroendocrinol (2000) 12 1047–1049
Hinney, A, Hoch, A, Geller, F, Schafer, H, Siegfried, W, Goldschmidt, H, Remschmidt, H & Hebebrand, JGhrelin gene: identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students. J Clin Endocrinol Metab (2002) 87 2716
Hirsh, D, Heinrichs, C, Leenders, B, Wong, AC, Cummings, DE & Chanoine, JPGhrelin is suppressed by glucagon and does not mediate glucagon-related growth hormone release. Horm Res (2005) 63 111–118
Holdstock, C, Engstrom, BE, Ohrvall, M, Lind, L, Sundbom, M & Karlsson, FAGhrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans. J Clin Endocrinol Metab (2003) 88 3177–3183
Holst, B, Cygankiewicz, A, Jensen, TH, Ankersen, M & Schwartz, TWHigh constitutive signaling of the ghrelin receptor identification of a potent inverse agonist. Mol Endocrinol (2003) 17 2201–2210
Horvath, TLThe hardship of obesity: a soft-wired hypothalamus. Nat Neurosci (2005) 8 561–565
Horvath, TL, Diano, S, Sotonyi, P, Heiman, M & Tschop, MMinireview: ghrelin and the regulation of energy balance – a hypothalamic perspective. Endocrinology (2001) 142 4163–4169
Hosoda, H, Kojima, M, Matsuo, H & Kangawa, KGhrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun (2000 a) 279 909–913
Hosoda, H, Kojima, M, Matsuo, H & Kangawa, KPurification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J Biol Chem (2000 b) 275 21995–22000
Hosoda, H, Kojima, M, Mizushima, T, Shimizu, S & Kangawa, KStructural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J Biol Chem (2003) 278 64–70
Howard, AD, Feighner, SD, Cully, DFet al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science (1996) 273 974–977
Huszar, D, Lynch, CA, Fairchild-Huntress, Vet al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell (1997) 88 131–141
Ikezaki, A, Hosoda, H, Ito, K, Iwama, S, Miura, N, Matsuoka, H, Kondo, C, Kojima, M, Kangawa, K & Sugihara, SFasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes (2002) 51 3408–3411
Jacobowitz, DM & O'Donohue, TLα-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain. Proc Natl Acad Sci U S A (1978) 75 6300–6304
Jeffery, PL, Duncan, RP, Yeh, AH, Jaskolski, RA, Hammond, DS, Herington, AC & Chopin, LKExpression of the ghrelin axis in the mouse: an exon 4-deleted mouse proghrelin variant encodes a novel C terminal peptide. peptide. Endocrinology (2005) 146 432–440
Kaiya, H, Kojima, M, Hosoda, H, Koda, A, Yamamoto, K, Kitajima, Y, Matsumoto, M, Minamitake, Y, Kikuyama, S & Kangawa, KBullfrog ghrelin is modified by n-octanoic acid at its third threonine residue. J Boil Chem (2001) 276 40441–40448
Kaiya, H, Kojima, M, Hosoda, H, Riley, LG, Hirano, T, Grau, EG & Kangawa, KIdentification of tilapia ghrelin and its effects on growth hormone and prolactin release in the tilapia, Oreochromis mossambicus. Comp Biochem Physiol (2003) 135B 421–429
Kalra, SP, Bagnasco, M, Otukonyong, EE, Dube, MG & Kalra, PSRhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity. Regul Pept (2003) 111 1–11
Kalra, SP & Kalra, PSNeuropeptide Y: a physiological orexigen modulated by the feedback action of ghrelin and leptin. Endocrine (2003) 22 49–56
Kalra, SP, Ueno, N & Kalra, PSStimulation of appetite by ghrelin is regulated by leptin restraint: peripheral and central sites of action. J Nutr (2005) 135 1331–1335
Kamegai, J, Tamura, H, Shimizu, T, Ishii, S, Sugihara, H & Wakabayashi, IChronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats. Diabetes (2001) 50 2438–2443
Kanamoto, N, Akamizu, T, Tagami, T, Hataya, Y, Moriyama, K, Takaya, K, Hosoda, H, Kojima, M, Kangawa, K & Nakao, KGenomic structure and characterization of the 5′-flanking region of the human ghrelin gene. Endocrinology (2004) 145 4144–4153
Kelley, AE & Berridge, KCThe neuroscience of natural rewards: relevance to addictive drugs. J Neurosci (2002) 22 3306–3311
Kemp, BE, Stapleton, D, Campbell, DJet al. AMP-activated protein kinase, super metabolic regulator. Biochem Soc Trans (2003) 31 162–168
Kim, MS & Lee, KURole of hypothalamic 5′-AMP-activated protein kinase in the regulation of food intake and energy homeostasis. J Mol Med (2005) 83 514–520
Kim, MS, Namkoong, C, Kim, HS, Jang, PG, Kim Pak, YM, Katakami, H, Park, JY & Lee, KUChronic central administration of ghrelin reverses the effects of leptin. Int J Obes Relat Metab Disord (2004) 28 1264–1271
Kim, SW, Her, SJ, Park, SJ, Kim, D, Park, KS, Lee, HK, Han, BH, Kim, MS, Shin, CS & Kim, SYGhrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells. Bone (2005) 37 359–369
Kishimoto, M, Okimura, Y, Nakata, H, Kudo, T, Iguchi, G, Takahashi, Y, Kaji, H & Chihara, KCloning and characterization of the 5(′)-flanking region of the human ghrelin gene. Biochem Biophys Res Commun (2003) 305 186–192
Kleinz, MJ, Maguire, JJ, Skepper, JN & Davenport, APFunctional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man. Cardiovasc Res (2006) 69 227–235
Kohno, D, Gao, HZ, Muroya, S, Kikuyama, S & Yada, TGhrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes (2003) 52 948–956
Kojima, M, Hosoda, H, Date, Y, Nakazato, M, Matsuo, H & Kangawa, KGhrelin is a growth-hormone-releasing acylated peptide from stomach. Nature (1999) 402 656–660
Kojima, M, Hosoda, H & Kangawa, KClinical endocrinology and metabolism. Ghrelin, a novel growth-hormone-releasing and appetite-stimulating peptide from stomach. Best Pract Res Clin Endocrinol Metab (2004) 18 517–530
Kojima, M, Hosoda, H, Matsuo, H & Kangawa, KGhrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Metab (2001) 12 118–122
Konturek, PC, Konturek, JW, Czesnikiewicz-Guzik, M, Brzozowski, T, Sito, E & Konturek, PCNeuro-hormonal control of food intake; basic mechanisms and clinical implications. J Physiol Pharmacol (2005) 56 suppl. 6, 5–25
Konturek, SJ, Konturek, JW, Pawlik, T & Brzozowski, YBrain–gut axis and its role in the control of food intake. J Physiol Pharmacol (2004) 55 137–154
Konturek, SJ, Pepera, J, Zabielski, K, Konturek, PC, Pawlik, T, Szlachcic, A & Hahn, EGBrain–gut axis in pancreatic secretion and appetite control. J Physiol Pharmacol (2003) 54 293–317
Koob, GFNeural mechanisms of drug reinforcement. Ann N Y Acad Sci (1992) 654 171–191
Korbonits, M, Bustin, SA, Kojima, M, Jordan, S, Adams, EF, Lowe, DG, Kangawa, K & Grossman, ABThe expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. J Clin Endocrinol Metab (2001) 86 881–887
Korbonits, M, Gueorguiev, M, O'Grady, E, Lecoeur, C, Swan, DC, Mein, CA, Weill, J, Grossman, AB & Froguel, PA variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. J Clin Endocrinol Metab (2002) 87 4005–4008
Lam, TK, Schwartz, GJ & Rossetti, LHypothalamic sensing of fatty acids. Nat Neurosci (2005) 8 579–584
Langenberg, C, Bergstrom, J, Laughlin, GA & Barrett-Connor, EGhrelin and the metabolic syndrome in older adults. J Clin Endocrinol Metab (2005) 90 6448–6453
Larsen, LH, Gjesing, AP, Sorensen, TI, Hamid, YH, Echwald, SM, Toubro, S, Black, E, Astrup, A, Hansen, T & Pedersen, OMutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes. Clin Biochem (2005) 38 420–424
Le Roux, CW, Neary, NM, Halsey, TJ, Small, CJ, Martinez-Isla, AM, Ghatei, MA, Theodorou, NA & Bloom, SRGhrelin does not stimulate food intake in patients with surgical procedures involving vagotomy. J Clin Endocrinol Metab (2005 a) 90 4521–4524
Le Roux, CW, Patterson, M, Vincent, RP, Hunt, C, Ghatei, MA & Bloom, SRPostprandial plasma ghrelin is suppressed proportional to meal calorie content in normal-weight but not obese subjects. J Clin Endocrinol Metab (2005 b) 90 1068–1071
Lee, HM, Wang, G, Englander, EW, Kojima, M & Greeley, GH JrGhrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology (2002) 143 185–190
Lucidi, P, Murdolo, G, Di Loreto, C, De Cicco, A, Parlanti, N, Fanelli, C, Santeusanio, F, Bolli, GB & De Feo, PGhrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia. Diabetes (2002) 51 2911–2914
McKeown, MAlternative mRNA splicing Annu Rev Cell Biol (1992) 8, 133–155
Maffeis, C, Bonadonna, RC, Consolaro, A, Vettor, R, Banzato, C, Silvagni, D, Bogoni, G, Pellegrino, M & Tato, LGhrelin, insulin sensitivity and postprandial glucose disposal in overweight and obese children. Eur J Endocrinol (2006) 154 61–68
Malagon, MM, Luque, RM, Ruiz-Guerrero, E, Rodriguez-Pacheco, F, Garcia-Navarro, S, Casanueva, FF, Gracia-Navarro, F & Castano, JPIntracellular signaling mechanisms mediating ghrelinstimulated growth hormone release in somatotropes. Endocrinology (2003) 144 5372–5380
Marx, JCellular warriors at the battle of the bulge. Science (2003) 299 846–852
Masuda, Y, Tanaka, T, Inomata, N, Ohnuma, N, Tanaka, S, Itoh, Z, Hosoda, H, Kojima, M & Kangawa, KGhrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun (2000) 276 905–908
Matsumoto, M, Hosoda, H, Kitajima, Y, Morozumi, N, Minamitake, Y, Tanaka, S, Matsuo, H, Kojima, M, Hayashi, Y & Kangawa, KStructure–activity relationship of ghrelin: pharmacological study of ghrelin peptides. Biochem Biophys Res Commun (2001) 287 42–46
Matzinger, D, Degen, L, Drewe, J, Meuli, J, Duebendorfer, R, Ruckstuhl, N, D'Amato, M, Rovati, L & Beglinger, CThe role of long chain fatty acids in regulating food intake and cholecystokinin release in humans. Gut (2000) 46 688–693
Mayer, JRegulation of energy intake and the body weight: the glucostatic theory and the lipostatic hypothesis. Ann N Y Acad Sci (1955) 63 15–43
Minokoshi, Y, Alquier, T, Furukawa, Net al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature (2004) 428 569–574
Minokoshi, Y, Haque, MS & Shimazu, TMicroinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats. Diabetes (1999) 48 287–291
Mohlig, M, Koebnick, C, Weickert, MO, Lueder, W, Otto, B, Steiniger, J, Twilfert, M, Meuser, F, Pfeiffer, AF & Zunft, HJrabinoxylan-enriched meal increases serum ghrelin levels in healthy humans. Horm Metab Res (2002) 37 303–308
Mohlig, M, Spranger, J, Otto, B, Ristow, M, Tschop, M & Pfeiffer, AFEuglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans. J Endocrinol Invest (2002) 25 RC36–RC38
Moran, LJ, Luscombe-Marsh, ND, Noakes, M, Wittert, GA, Keogh, JB & Clifton, PMThe satiating effect of dietary protein is unrelated to postprandial ghrelin secretion. J Clin Endocrinol Metab (2005) 90 5205–5211
Muccioli, G, Papotti, M, Locatelli, V, Ghigo, E & Deghenghi, RBinding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland. J Endocrinol Invest (2001) 24 RC7–RC9
Muccioli, G, Pons, N, Ghe, C, Catapano, F, Granata, R & Ghigo, EGhrelin and des-acyl ghrelin both inhibit isoproterenolinduced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor. Eur J Pharmacol (2004) 498 27–35
Muller, AF, Lamberts, SW, Janssen, JA, Hofland, LJ, Koetsveld, PV, Bidlingmaier, M,Strasburger, CJ,Ghigo, E & van der Lely, AJGhrelin drives GH secretion during fasting in man. Eur J Endocrinol (2002) 146 203–207
Murashita, M, Kusumi, I, Inoue, T, Takahashi, Y, Hosoda, H, Kangawa, K, Koyama, TOlanzapine increases plasma ghrelin level in patients with schizophrenia. Psychoneuroendocrinology (2005) 30 106–110
Murata, M, Okimura, Y, Iida, K,Matsumoto, M,Sowa, H,Kaji, H,Kojima, M,Kangawa, K & Chihara, KGhrelin modulates the downstream molecules of insulin signaling in hepatoma cells. J Biol Chem (2002) 15, 5667–5674.
Mustonen, AM, Nieminen, P & Hyvarinen, HPreliminary evidence that pharmacologic melatonin treatment decreases rat ghrelin levels. Endocrine (2001) 16, 43–46.
Nagaya, N, Kojima, M, Uematsu, M,Yamagishi, M,Hosoda, H,Oya, H,Hayashi, Y & Kangawa, KHemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol (2001 a) 280,R1483–R1487.
Nagaya, N, Miyatake, K, Uematsu, M,Oya, H,Shimizu, W,Hosoda, H,Kojima, M,Nakanishi, N,Mori, H & Kangawa, WHemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure. J Clin Endocrinol Metab (2001 b) 86,5854–5859.
Nakagawa, E, Nagaya, N, Okumura, H,Enomoto, M,Oya, H,Ono, F,Hosoda, H,Kojima, M &Kangawa, KHyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose. Clin Sci (Lond) (2002) 103,325–328.
Nakai, Y, Hosoda, H, Nin, K,Ooya, C,Hayashi, H,Akamizu, T & Kangawa, kPlasma levels of active form of ghrelin during oral glucose tolerance test in patients with anorexia nervosa. Eur J Endocrinol (2003) 149,R001–R003.
Nakazato, M, Murahami, N, Date, M,Kojima, M,Matsuo, H,Kangawa, K & Matsukura, SARole for ghrelin in the central regulation of feeding. Nature (2001) 409,194–198.
Naleid, AM, Grace, MK, Cummings, DE & Levine, ASGhrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens. Peptides (2005) 26,2274–2279.
Obici, S, Feng, Z, Tan, J,Liu, L,Karkanias, G – Rossetti, LCentral
melanocortin receptors regulate insulin action.J Clin Invest
Obici, S, Zhang, BB, Karkanias, G & Rossetti, LHypothalamic insulin signaling is required for inhibition of glucose production. Nat Med (2002) 8,1376–1382.
Ott, V, Fasshauer, M, Dalski, A,Meier, B,Perwitz, N,Klein, HH,Tschop, M & Klein, JDirect peripheral effects of ghrelin include suppression of adiponectin expression. Horm Metab Res (2002) 34,640–645.
Otto, B, Spranger, J, Benoit, SC,Clegg, DJ – Tschop, MHThe many faces of ghrelin: new perspectives for nutrition research? Br J Nutr (2005) 93,765–771.
Otukonyong, EE, Dube, MG, Torto, R,Kalra, PS & Kalra, spHigh-fat diet-induced ultradian leptin and insulin hypersecretion are absent in obesity-resistant rats. Obes Res (2005) 13,991–999.
Shrestha, YB, Wickwire, K & Giraudo, SQRole of AgRP on ghrelin-induced feeding in the hypothalamic paraventricular
nucleus. Regul Pept (2006) 133,68–73.
Silva-Elipe, MV, Bednarek, MA & Gao, YD1H NMR structural analysis of human ghrelin and its six truncated analogs. Biopolymers (2001) 59,489–501.
Smith, RG, Jiang, H & Sun, YDevelopments in ghrelin biology and potential clinical relevance. Trends Endocrinol Metab (2005) 16,436–442.
Snitker, S, Tataranni, PA & Ravussin, ERespiratory quotient is inversely associated with muscle sympathetic nerve activity J Clin Endocrinol Metab (1998) 83,3977–3979.
Soriano-Guillen, L, Barrios, V, Campos-Barros, A & Argente, J (2004) Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation. J Pediatr 144,36–42.
Soule, S, Pemberton, C, Hunt, P,Cole, D,Raudsepp, S & Inder, WPrandial regulation of ghrelin secretion in humans: does glucagon contribute to the preprandial increase in circulating ghrelin? Clin Endocrinol (Oxf) (2005) 63,412–417.
Steinle, NI, Pollin, TI, O'Connell, JR, Mitchell, BD & Shuldiner, ARVariants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish. J Clin Endocrinol Metab (2005) 90,6672–6677.
Sun, Y, Ahmed, S & Smith, RGDeletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol (2003) 23,7973–7981.
Sun, Y, Wang, P, Zheng, H & Smith, RGGhrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci U S A (2004) 101,4679–4684.
Takaya, K, Ariyasu, H, Kanamoto, N, et al..Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab (2000) 85,4908–4911.
Tamura, H, Kamegai, J, Shimizu, T,Ishii, SSugihara, H & Oikawa, SGhrelin stimulates GH but not food intake in arcuate nucleus ablated rats. Endocrinology (2002) 143,3268–3275.
Tanaka, M, Hayashida, Y, Iguchi, T,Nakao, N,Nakai, N & Nakashima, KOrganization of the mouse ghrelin gene and promoter:occurrence of a short noncoding first exon. Endocrinology (2001) 142,3697–3700.
Tanaka, M, Naruo, T, Muranaga, T,Yasuhara, D,Shiiya, T,Nakazato, M,Matsukura, S & Nozoe, SIncreased fasting plasma ghrelin levels in patients with bulimia nervosa. Eur J Endocrinol (2002) 146,R1–R3.
Teff, KL, Elliott, SS, Tschop, M,Kieffer, TJ, Rader, D, Heiman, M, Townsend, RR, Keim, NL, D'Alessio, D – Havel, PJDietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab (2004) 89,2963–2972.
Tena-Sempere, MGhrelin: novel regulator of gonadal function. J Endocrinol Invest (2005) 28,26–29.
Thompson, NM, Gill, DA, Davies, R,Loveridge, N,Houston, PA,Robinson, IC & Wells, TGhrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology (2004) 145,234–242.
Tolle, V, Kadem, M, Bluet-Pajot, MT,et al.. Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women. J Clin Endocrinol Metab (2003) 88,109–116.
Tomas, E, Tsao, TS, Saha, AK,Murrey, HE,Zhang, CC,Itani, SI,Lodish, HF & Ruderman, NBEnhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A (2002) 99,16309–16313.
Tomasetto, C, Karam, SM, Ribieras, S,Masson, R,Lefebvre, O,Staub, A,Alexander, G,Chenard, MP & Rio, MCIdentification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology (2000) 119,395–405.
Toshinai, K, Date, Y, Murakami, N,et al.. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology (2003) 144,1506–1512.
Toshinai, K, Mondal, MS, Nakazato, M,Date, Y,Murakami, N,Kojima, M,Kangawa, K & Matsukura, sUpregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun (2001) 281,281–1225.
Tschop, M, Flora, DB, Mayer, JP & Heiman, MLHypophysectomy prevents ghrelin-induced adiposity and increases gastric ghrelin secretion in rats. Obes Res (2002) 10,991–999.
Tschop, M, Smiley, DL & Heiman, MLGhrelin induces adiposity in rodents. Nature (2000) 407,908–913.
Tschop, M, Wawarta, R, Riepl, RL,Friedrich, S,Bidlingmaier, M,Landgraf, R & Folwaczny, cPost-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest (2001) 24,RC19–RC21.
Turnley, AM, Stapleton, D, Mann, RJ,Witters, LA,Kemp, BE & Bartlett, PFCellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem (1999) 72,1707–1716.
Ukkola, OGhrelin and the metabolic balance. J Endocrinol Invest (2005) 28,849–852.
Ukkola, O, Ravussin, E, Jacobson, P,Snyder, EE,Chagnon, M,Sjostrom, L & Bouchard, cMutations in the preproghrelin/ghrelin gene associated with obesity in humans. J Clin Endocrinol Metab (2001) 86,3996–3999.
van der Lely, AJ, Tschop, M, Heiman, ML & Ghigo, EBiological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev (2004) 25,426–457.
Viollet, B, Andreelli, F, Jorgensen, SB,et al.. The AMPactivated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest (2003) 111,91–98.
Vivenza, D, Rapa, A, Castellino, N,Bellone, S,Petri, A,Vacca, G,Aimaretti, G,Broglio, F & Bona, GGhrelin gene polymorphisms and ghrelin, insulin, IGF-I, leptin and anthropometric data in children and adolescents. Eur J Endocrinol (2004) 151,127–133.
Wajnrajch, MP, Ten, IS, Gertner, JM & Leibel, RLGenomic organization of the ghrelin gene. J Endo Gen (2000) 1,231–233.
Wang, L, Saint-Pierre, DH & Tache, YPeripheral ghrelin selectively increases Fos expression in neuropeptide Y-synthesizing neurons in mouse hypothalamic arcuate nucleus. Neurosci Lett (2002) 325,47–51.
Watson, SJ, Akil, H, Richard, CW III & Barchas, JDEvidence for two separate opiate peptide neuronal systems. Nature (1978) 275,226–228.
Weber, E, Esch, FS, Bohlen, P,Paterson, S,Corbett, AD,McKnight, AT,Kosterlitz, HW,Barchas, JD & Evans, CJMetorphamide:isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. Proc Natl Acad Sci U S A (1983) 80,7362–7366.
Wierup, N, Yang, S, McEvilly, RJ,Mulder, H & Sundler, FGhrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells. J Histochem Cytochem (2004) 52,301–310.
Wiley, KE & Davenport, APComparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin-1. Br J Pharmacol (2002) 136,1146–1152.
Williams, J & Mobarhan, SA critical interaction: leptin and ghrelin. Nutr Rev (2003) 61,391–393.
Woods, SC, Stein, LJ, McKay, LD & Porte, D JrSuppression of food intake by intravenous nutrients and insulin in the baboon. Am J Physiol (1984) 247, R393–R401.
Wortley, KE, Anderson, KD, Garcia, K et al. . Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference Proc Natl Acad Sci U S A (2004) 101,8227–8232.
Wortley, KE, del Rincon, JP, Murray, JD,Garcia, K,Iida, K,Thorner, MO – Sleeman, MWAbsence of ghrelin protects against early-onset obesity. J Clin Invest (2005) 115,3573–3578.
Wren, AM, Seal, LJ, Cohen, MA, Brynes, AE, Frost, GS, Murphy, KG, Dhillo, WS,Ghatei, MA – Bloom, SRGhrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab (2001) 86, 5992–5995.
Yamanaka, AHypothalamic orexin neurons regulate arousal according to energy balance in mice Neuron (2003) 38 701–713
Yamauchi, T, Kamon, J & Minokoshi, Y et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Nat Med (2002) 8 1288–1295
Yeh, AH, Jeffery, PL, Duncan, RP, Herington, AC, Chopin, LKGhrelin and a novel preproghrelin isoform are highly expressed in prostate cancer and ghrelin activates mitogen-activated protein kinase in prostate cancer. Clin Cancer Res (2005) 11, 8295–8303.
Yeh, LA, Lee, KH, Kim, KHRegulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl CoA carboxylase by adenylate energy charge. J Biol Chem (1980) 255, 2308–2314.
Yildiz, BO, Suchard, MA, Wong, ML, McCann, SM, Licinio, JAlterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. Proc Natl Acad Sci U S A (2004) 101, 10434–10439.
Yokota, I, Kitamura, S, Hosoda, H, Kotani, Y, Kangawa, KConcentration of the n-octanoylated active form of ghrelin in fetal and neonatal circulation. Endocr J (2005) 52, 271–276.
Zhang, JV, Ren, PG, Avsian-Kretchmer, O, Luo, CW, Rauch, R, Klein, C, Hsueh, AJObestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science (2005) 310, 996–999.
Zigman, JM, Nakano, Y, Coppari, R et al. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest (2005) 115, 3564–3572.
Zong, H, Ren, JM, Young, LH, Pypaert, M, Mu, J, Birnbaum, MJ, Shulman, GIAMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A (2002) 99, 15983–15987.