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Free amino acid patterns of plasma, erythrocytes and leucocytes in hypoproteinaemia

Published online by Cambridge University Press:  24 July 2007

Meera Gupta  and
K. N. Agarwal
Meera Gupta
Affiliation:
Paediatric Uaematology Unit, Institute of Medical Sciences, Varanasi, India
K. N. Agarwal
Affiliation:
Paediatric Uaematology Unit, Institute of Medical Sciences, Varanasi, India
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Abstract

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1. In pregnancy, severe hypoproteinaemia, cirrhosis and anaemia, plasma free α-amino nitrogen (FαAN) was found to be lowered. The non-essential:essential amino acid ratios, determined by paper chromatography, were increased in hypoproteinaemia and anaemia.

2. The erythrocytic FαAN content increased in early hypoproteinaemia and values lower than normal were found in severe hypoproteinaemia. There was also a rise in anaemia, which was due to increased cellular non-essential amino acids.

3. The leucocytic FαAN was reduced in all hypoproteinaemic states. The increased FαAN values in patients with thyrotoxicosis demonstrated that, in catabolism, leucocytic uptake of amino acids is increased. The non-essential:essential amino acid ratios were decreased in cirrhosis, possibly due to poor biosynthesis of non-essential amino acids by the liver.

Type
Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 29 , Issue 2 , March 1973 , pp. 151 - 157
Copyright
Copyright © The Nutrition Society 1973

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