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Erythrocyte morphology and filterability in rats fed on diets containing different fats and oils

  • Alison J Maccoll (a1), Kerry A. C James (a2) and Chris L Booth (a1)

Abstract

The present study aimed to determine if the type of dietary fat or oil affects erythrocyte morphology and/or filterability in normal healthy rats. A feeding trial was carried out, in which nine groups of nine rats were fed on diets containing one of the following treatments (test fats or oils): anhydrous milk fat, anhydrous milk fat after passage through a column of active carbon, palm oil, MaxEPA fish oil, hydrogenated coconut oil, anhydrous tallow shortening, margarine hardstock, olive oil and soyabean oil. The test fats or oils supplemented with 10 g safflower-seed oil/kg were incorporated into otherwise nutritionally adequate diets so that the test fat or oil plus safflower- oil contributed 35% of the gross energy of the diet. The rats were fed for 10 weeks. Diet had a significant effect on five of the six classes of erythrocytes identified, and the proportion of cells in each class was shown to be dependent on diet. However, the attribute causing the dependence was not clear. There was no significant effect of diet on erythrocyte filterability index. There was no statistical correlation between erythrocyte filterability index and morphology. Although it has been observed that diet, particularly fish oil, can improve the filterability of erythrocytes once filterability is impaired, the effect of diet on erythrocyte filterability in normal healthy animals including humans is unclear. The importance of the differences in erythrocyte morphology due to diet is also unclear. Both areas deserve further investigation.

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References

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Chien, S. (1977). Principles and techniques for assessing erythrocyte deformability. Blood Cells 3, 7199.
Drummond, M. M., Lowe, G. D. O., Belch, J. T. F., Barbene, J. C. & Forbes, C. D. (1980). An assessment of red cell deformability using a simple filtration method. Journal of Clinical Pathology 33, 373376.
Ernst, E. (1989). Effects of n-3 fatty acids on blood rheology. Journal of Internal Medicine 225, Suppl. 1, 129132.
Levenson, J., Del Pino, M., Razavian, M., Merli, I., Filitti, V. & Simon, A. (1992). Hypercholesterolaemia alters arterial and blood factors related to atherosclerosis in hypertension. Atherosclerosis 95, 171179.
Minitab, (1994). Minitab Reference Manual Release 10 for Windows. State College, PA: Minitab Inc.
Reid, H. L., Barnes, A. J., Lock, P. J., Dormandy, J.A & Dormandy, T. L. (1976 a). A simple method formeasuring erythrocyte deformability. Journal of Clinical Pathology 29 855858.
Reid, H. L., Dormandy, J. A., Barnes, A. J., Lock, P. J. & Dormandy, T. L. (1976 b). Impaired red cell deformability in peripheral vascular disease. Lancet i, 666668.
Simpson, L. O. (1989). Blood from healthy animals and humans contains nondiscocytic erythrocytes. British Journal of Haematology 73, 561564.
Simpson, L. O. (1993). The effects of saline solutions on red cell shape a scanning-electron-microscope-based study. British Journal of Haematology 85, 832834.
Simpson, L. O., Shand, B. I., Olds, R. J., Larking, P. W. & Arnott, M. J. (1987). Red cell and haemorheological changes in multiple sclerosis. Pathology 19, 5155.
Statistical Analysis Systems (1994). SAS User's Guide, Statistics. Cary, NC: SAS Institute Inc.
StatSci (1994). S-Plus for Windows, V3.2 Supplement. Seattle, WA: MathSoft, Inc.
Terano, T., HaraiA, A,, Hamazaki, T., Kobayashi, S., Fujita, T., Tamura, Y. & Kumagai, A. (1983). Effectof oral administration of highly purified eicosapentaenoic acid on platelet function, blood viscosity and red cell deformability in healthy human subjects. Atherosclerosis 46, 321331.

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Erythrocyte morphology and filterability in rats fed on diets containing different fats and oils

  • Alison J Maccoll (a1), Kerry A. C James (a2) and Chris L Booth (a1)

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