Hostname: page-component-77c89778f8-m8s7h Total loading time: 0 Render date: 2024-07-19T11:06:47.323Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of long-term calcium supplementation on indices of iron, zinc and magnesium status in lactating Gambian women

Published online by Cambridge University Press:  09 March 2007

Liya Yan ,
Ann Prentice ,
Bakary Dibba ,
Landing M. A. Jarjou ,
Dorothy M. Stirling  and
Susan Fairweather-Tait
Liya Yan
Affiliation:
Medical Research Council Dunn Nutrition Unit, Downhams Lane, Milton Road, Cambridge CB4 1XJ and Keneba, PO Box 273, The Gambia
Ann Prentice
Affiliation:
Medical Research Council Dunn Nutrition Unit, Downhams Lane, Milton Road, Cambridge CB4 1XJ and Keneba, PO Box 273, The Gambia
Bakary Dibba
Affiliation:
Medical Research Council Dunn Nutrition Unit, Downhams Lane, Milton Road, Cambridge CB4 1XJ and Keneba, PO Box 273, The Gambia
Landing M. A. Jarjou
Affiliation:
Medical Research Council Dunn Nutrition Unit, Downhams Lane, Milton Road, Cambridge CB4 1XJ and Keneba, PO Box 273, The Gambia
Dorothy M. Stirling
Affiliation:
Medical Research Council Dunn Nutrition Unit, Downhams Lane, Milton Road, Cambridge CB4 1XJ and Keneba, PO Box 273, The Gambia
Susan Fairweather-Tait
Affiliation:
Institute of Food Research, Norwich Laboratory, Norwich Research Park, Colney, Norwich NR4 7UA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The effect of long-term supplementation with CaCO3 on indices of Fe, Zn and Mg status was investigated in a randomized, double-blind intervention study of sixty lactating Gambian women. The supplement contained 1000 mg Ca and was consumed between meals 5 d/week, for 1 year starting 1.5 weeks postpartum. Compliance was 100%. Plasma ferritin concentration, plasma Zn concentration and urinary Mg output were measured before, during and after supplementation at 1.5, 13, 52 and 78 weeks postpartum. No significant differences in mineral status were observed at any time between women in the supplement and placebo group. Analysis of the longitudinal data series showed that plasma ferritin and Mg excretion were characteristic of the indivdiual (P < 0·001). Within individuals, ferritin concentration was higher at 1.5 weeks postpartum than later in lactation (P = 0.002). Plasma Zn concentration was lower at 1.5 weeks postpartum than at other tima (P < 0·001), an effect which disappeared after albumin correction. Low plasma concentrations of ferritin and Zn indicated that the Gambian women were at high risk of Fe and Zn deficiency. Measurements of α1-antichymotrypsin suggested that the results were not confounded by acute-phase responses. The results of the present study indicate that 1000 mg Ca as CaCO3 given between meals does not deleteriously affect plasma ferritin and Zn concentrations or urinary Mg excretion in women who are at risk of Fe and Zn deficiency

Keywords

CalciumMineral interactionsLactation
Type
Human and Clinical Nutrition
Information
British Journal of Nutrition , Volume 76 , Issue 6 , December 1996 , pp. 821 - 831
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Aggett, P. J. & Favier, A. (1993). Flair Concerted Action No. 10 Status Papers: Zinc. International Journal for Vitamin and Nutrition Research 63, 301–307.Google Scholar
Argiratos, V. & Samman, S. (1994). The effect of calcium carbonate and calcium citrate on the absorption of zinc in healthy female subjects. European Journal of Clinical Nutrition 48, 198–204.Google ScholarPubMed
Calvin, J., Neale, G., Fotherby, K. J. & Price, C. P. (1988). The relative merits of acute phase proteins in the recognition of inflammatory conditions. Annals of clinical Biochemistry 25, 60–66.CrossRefGoogle ScholarPubMed
Cook, J. D., Dassenko, S. A. & Whittaker, P. (1991). Calcium supplementation: effect on iron absorption. American Journal of Clinical Nutrition 53, 106–111.CrossRefGoogle ScholarPubMed
Data Description Inc. (1993). DataDesk 4.1. Ithaca, NY: Data Description Inc.Google Scholar
Dawson-Hughes, B., Seligson, F. H. & Hughes, V. A. (1986). Effects of calcium carbonate and hydroxyapatite on zinc and iron retention in postmenopausal women. American Journal of Clinical Nutrition 44, 83–88.Google Scholar
Fairweather-Tait, S. J. (1993). Flair Concerted Action No. 10 Status Papers: Iron. International Journal for Vitamin and Nutrition Research 63, 296–301.Google Scholar
Fairweather-Tait, S. J. (1995). Iron-zinc and calcium-Fe interactions in relation to Zn and Fe absorption. Proceedings of the Nutrition Society 54, 465–473.CrossRefGoogle ScholarPubMed
Fairweather-Tait, S. J., Prentice, A., Heumann, K. G., Jarjou, L. M. A., Stirling, D. M., Wharf, S. G. & Turnlund, J. R. (1995). Effect of calcium supplements and stage of lactation on the efficiency of absorption of calcium by lactating women accustomed to low calcium intakes. American Journal of Clinical Nutrition 62, 1188–1192.CrossRefGoogle ScholarPubMed
Ferguson, E. L., Gibson, R. S., Thompson, L. U. & Ounpuu, S. (1989). Dietary calcium, phytate, and zinc intakes and the calcium, phytate, and zinc molar ratios of the diets of a selected group of East African children. American Journal of Clinical Nutrition 50, 1450–1456.CrossRefGoogle ScholarPubMed
Gossel, T. A. (1991). Calcium supplements. US Pharmacist April issue, 26–32.Google Scholar
Hallberg, L., Rossander-Hulthén, L., Brune, M. & Gleerup, A. (1992). Calcium and iron absorption: mechanism of action and nutritional importance. European Journal of Clinical Nutrition 46, 317–327.Google ScholarPubMed
Heaney, R. P. (1991). Calcium supplements: practical considerations. Osteoporosis International 1, 65–71.CrossRefGoogle ScholarPubMed
Karra, M. V., Kirksey, A., Galal, O., Bassily, N. S., Harrison, G. G. & Jerome, N. W. (1988). Zinc, calcium and magnesium concentrations in milk from American and Egyptian women throughout the first 6 months of lactation. American Journal of Clinical Nutrition 47, 642–648.Google Scholar
Krebs, N. F., Redinger, C. J., Hartley, S., Robertson, A. D. & Hambidge, K. M. (1995). Zinc supplementation during lactation: effects on maternal status and milk Zinc concentrations. American Journal of Clinical Nutrition 61, 1030–1036.CrossRefGoogle ScholarPubMed
Levenson, D. I. & Bockman, R. S. (1994). A review of calcium preparations. Nutrition Reviews 52, 221–232.CrossRefGoogle ScholarPubMed
Moser, P. B. & Reynolds, R. D. (1983). Dietary zinc intakes and zinc concentrations of plasma, erythrocytes and breast milk in antepartum and postpartum lactating and nonlactating women: a longitudinal study. American Journal of Clinical Nutrition 38, 101–108.CrossRefGoogle ScholarPubMed
NIH Consensus Statement (1994). Optimal calcium intake. Journal of the American Medical Association 272, 1942–1948.CrossRefGoogle Scholar
Prentice, A. (1991). Functional significance of marginal calcium deficiency. In Modern Lifestyles, Lower Energy Intake and Micronutrient Status, pp. 139–154 [Peitrzik, K., editor]. London: Springer-Verlag.CrossRefGoogle Scholar
Prentice, A. (1994). Maternal calcium requirements during pregnancy and lactation. American Journal of Clinical Nutrition 59S, 477–483.CrossRefGoogle Scholar
Prentice, A., Jarjou, L. M. A., Cole, T. J., Stirling, D. M., Dibba, B. & Fairweather-Tit, S. (1995). Calcium requirements of lactating Gambian mothers: effects of a calcium supplement on breast-milk calcium concentration, maternal bone mineral content and urinary calcium excretion. American Journal of Clinical Nutrition 65, 58–67.CrossRefGoogle Scholar
Sokoll, L. J. & Dawson-Hughes, B. (1992). Calcium supplementation and plasma ferritin concentrations in premenopausal women. American Journal of Clinical Nutrition 56, 1045–1048.CrossRefGoogle ScholarPubMed
Spencer, H., Kramer, L., Norris, C. & Osis, D. (1984). Effect of calcium and phosphorus on zinc metabolism in man. American Journal of Clinical Nutrition 40, 1213–1218.CrossRefGoogle ScholarPubMed
Tsang, W. M., Howell, M. J. & Miller, A. L. (1988). A simple enzymatic method for the measurement of magnesium in serum and urine on a centrifugal analyser. Annals of Clinical Biochemistry 25, 162–168.CrossRefGoogle Scholar
Wacker, W. E. C. & Vallee, B. L. (1964). Magnesium. In Mineral Metabolism: An Advanced Treatise, pp. 483–521 [Comar, C. L. and Bronner, F., editors]. New York: Academic Press.Google Scholar
Whiting, S. (1995). The inhibitory effect of dietary calcium on iron bioavailability: a cause for concern? Nutrition Reviews 53, 77–80.Google Scholar