1Department of Health (2004) . Health Survey for England. London: National Statistics.
2Mokdad, AH, Ford, ES, Bowman, BA, Dietz, WH, Vinicor, F, Bales, VS & Marks, JS (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289, 76–79.
3Samuelson, G (2000) Dietary habits and nutritional status in adolescents over Europe. An overview of current studies in the Nordic countries. Eur J Clin Nutr 54, S21–S28.
4Berteus-Forslund, H, Torgerson, JS, Sjostrom, L & Lindroos, AK (2005) Snacking frequency in relation to energy intake and food choices in obese men and women compared to a reference population. Int J Obes Relat Metab Disord 29, 711–719.
5Woods, SC (2004) Gastrointestinal Satiety Signals I. An overview of gastrointestinal signals that influence food intake. Am J Physiol Gastrointest Liver Physiol 286, G7–G13.
6Stanley, S, Wynne, K & Bloom, S (2004) Gastrointestinal Satiety Signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide. Am J Physiol Gastrointest Liver Physiol 286, G693–G697.
7Moran, TH & Kinzig, KP (2004) Gastrointestinal Satiety Signals II. Cholecystokinin. Am J Physiol Gastrointest Liver Physiol 286, G183–G188.
8Kojima, M, Hosoda, H, Date, Y, Nakazato, M, Matsuo, H & Kangawa, K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656–660.
9Sugino, T, Yamaura, J, Yamagishi, M, et al. (2002) A transient surge of ghrelin secretion before feeding is modified by different feeding regimens in sheep. Biochem Biophys Res Commun 298, 785–788.
10Flanagan, DE, Evans, ML, Monsod, TP, Rife, F, Heptulla, RA, Tamborlane, WV & Sherwin, RS (2003) The influence of insulin on circulating ghrelin. Am J Physiol Endocrinol Metab 284, E313–E316.
11Murdolo, G, Lucidi, P, Di Loreto, C, et al. (2003) Insulin is required for prandial ghrelin suppression in humans. Diabetes 52, 2923–2927.
12Saad, MF, Bernaba, B, Hwu, CM, Jinagouda, S, Fahmi, S, Kogosov, E & Boyadjian, R (2002) Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 87, 3997–4000.
13Tschop, M, Weyer, C, Tataranni, PA, Devanarayan, V, Ravussin, E & Heiman, ML (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes 50, 707–709.
14McLaughlin, T, Abbasi, F, Lamendola, C, Frayo, RS & Cummings, DE (2004) Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls. J Clin Endocrinol Metab 89, 1630–1635.
15British Nutrition Foundation (2004) . British Nutrition Foundation National Diet Survey. London: National Statistics.
16Bertelsen, J, Christiansen, C, Thomsen, C, Poulsen, PL, Vestergaard, S, Steinov, A, Rasmussen, LH, Rasmussen, O & Hermansen, K (1993) Effect of meal frequency on blood glucose, insulin, and free fatty acids in NIDDM subjects. Diabetes Care 16, 4–7.
17Farshchi, HR, Taylor, MA & Macdonald, IA (2004) Regular meal frequency creates more appropriate insulin sensitivity and lipid profiles compared with irregular meal frequency in healthy lean women. Eur J Clin Nutr 58, 1071–1077.
18Murphy, MC, Chapman, C, Lovegrove, JA, Isherwood, SG, Morgan, LM, Wright, JW & Williams, CM (1996) Meal frequency; does it determine postprandial lipaemia? Eur J Clin Nutr 50, 491–497.
19Farshchi, HR, Taylor, MA & Macdonald, IA (2005) Beneficial metabolic effects of regular meal frequency on dietary thermogenesis, insulin sensitivity, and fasting lipid profiles in healthy obese women. Am J Clin Nutr 81, 16–24.
20Arnold, L, Mann, JI & Ball, MJ (1997) Metabolic effects of alterations in meal frequency in type 2 diabetes. Diabetes Care 20, 1651–1654.
21Iwao, S, Mori, K & Sato, Y (1996) Effects of meal frequency on body composition during weight control in boxers. Scand J Med Sci Sports 6, 265–272.
22Jenkins, DJ, Wolever, TM, Vuksan, V, et al. (1989) Nibbling versus gorging: metabolic advantages of increased meal frequency. N Engl J Med 321, 929–934.
23Veldhuis, JD & Johnson, ML (1986) Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. Am J Physiol 250, E486–E493.
24Veldhuis, JD, Johnson, ML & Seneta, E (1991) Analysis of the copulsatility of anterior pituitary hormones. J Clin Endocrinol Metab 73, 569–576.
25Meneilly, GS, Veldhuis, JD & Elahi, D (2006) Pulsatile insulin secretion in elderly patients with diabetes. Diabetes Res Clin Pract 73, 218–220.
26Box, GJ, Jenkins, GM & Reinsel, G (1994) Time Series Analysis: Forecasting & Control, 3rd ed.London: Prentice Hall.
27Carroll, D (1977) Cardiac perception and cardiac control. A review. Biofeedback Self Regul 2, 349–369.
28Mohlig, M, Spranger, J, Otto, B, Ristow, M, Tschop, M & Pfeiffer, AF (2002) Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans. J Endocrinol Invest 25, RC36–RC38.
29Cummings, DE, Purnell, JQ, Frayo, RS, Schmidova, K, Wisse, BE & Weigle, DS (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50, 1714–1719.
30Peino, R, Baldelli, R, Rodriguez-Garcia, J, et al. (2000) Ghrelin-induced growth hormone secretion in humans. Eur J Endocrinol 143, R11–R14.
31Lucidi, P, Murdolo, G, Di Loreto, C, De Cicco, A, Parlanti, N, Fanelli, C, Santeusanio, F, Bolli, GB & De Feo, P (2002) Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia. Diabetes 51, 2911–2914.
32McCowen, KC, Maykel, JA, Bistrian, BR & Ling, PR (2002) Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents. J Endocrinol 175, R7–R11.
33Anderwald, C, Brabant, G, Bernroider, E, Horn, R, Brehm, A, Waldhausl, W & Roden, M (2003) Insulin-dependent modulation of plasma ghrelin and leptin concentrations is less pronounced in type 2 diabetic patients. Diabetes 52, 1792–1798.
34van der Lely, AJ, Tschop, M, Heiman, ML & Ghigo, E (2004) Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25, 426–457.
35Barazzoni, R, Bosutti, A, Stebel, M, et al. (2005) Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle. Am J Physiol Endocrinol Metab 288, E228–E235.
36Wortley, KE, Anderson, KD, Garcia, K, et al. (2004) Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci U S A 101, 8227–8232.
37Jenkins, DJ, Wolever, TM, Ocana, AM, et al. (1990) Metabolic effects of reducing rate of glucose ingestion by single bolus versus continuous sipping. Diabetes 39, 775–781.
38Meier, U & Gressner, AM (2004) Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 50, 1511–1525.
39Seoane, LM, Lopez, M, Tovar, S, Casanueva, FF, Senaris, R & Dieguez, C (2003) Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. Endocrinology 144, 544–551.
40Callahan, HS, Cummings, DE, Pepe, MS, Breen, PA, Matthys, CC & Weigle, DS (2004) Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans. J Clin Endocrinol Metab 89, 1319–1324.
41Murakami, N, Hayashida, T, Kuroiwa, T, Nakahara, K, Ida, T, Mondal, MS, Nakazato, M, Kojima, M & Kangawa, K (2002) Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats. J Endocrinol 174, 283–288.
42Hotta, M, Ohwada, R, Katakami, H, Shibasaki, T, Hizuka, N & Takano, K (2004) Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa. J Clin Endocrinol Metab 89, 5707–5712.
43Thompson, NM, Gill, DA, Davies, R, Loveridge, N, Houston, PA, Robinson, IC & Wells, T (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 145, 234–242.
44Koutkia, P, Canavan, B, Breu, J, Johnson, ML & Grinspoon, SK (2004) Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men. Am J Physiol Endocrinol Metab 287, E506–E512.
45Paik, HS & Yearick, ES (1978) The influence of dietary fat and meal frequency on lipoprotein lipase and hormone-sensitive lipase in rat adipose tissue. J Nutr 108, 1798–1805.
46Toschke, AM, Kuchenhoff, H, Koletzko, B & von Kries, R (2005) Meal frequency and childhood obesity. Obes Res 13, 1932–1938.
47Hampl, JS, Heaton, CL & Taylor, CA (2003) Snacking patterns influence energy and nutrient intakes but not body mass index. J Hum Nutr Diet 16, 3–11.
48Drummond, S, Crombie, N & Kirk, T (1996) A critique of the effects of snacking on body weight status. Eur J Clin Nutr 50, 779–783.
49Gatenby, SJ (1997) Eating frequency: methodological and dietary aspects. Br J Nutr 77, Suppl. 1, S7–S20.
50LeBlanc, J, Mercier, I & Nadeau, A (1993) Components of postprandial thermogenesis in relation to meal frequency in humans. Can J Physiol Pharmacol 71, 879–883.
51de Bont, AJ, Romsos, DR, Tsai, AC, Waterman, RA & Leveille, GA (1975) Influence of alterations in meal frequency on lipogenesis and body fat content in the rat. Proc Soc Exp Biol Med 149, 849–854.
52Molon-Noblot, S, Keenan, KP, Coleman, JB, Hoe, CM & Laroque, P (2001) The effects of ad libitum overfeeding and moderate and marked dietary restriction on age-related spontaneous pancreatic islet pathology in Sprague-Dawley rats. Toxicol Pathol 29, 353–362.
53Garrow, JS, Durrant, M, Blaza, S, Wilkins, D, Royston, P & Sunkin, S (1981) The effect of meal frequency and protein concentration on the composition of the weight lost by obese subjects. Br J Nutr 45, 5–15.
54Verboeket-van de Venne, WP & Westerterp, KR (1993) Frequency of feeding, weight reduction and energy metabolism. Int J Obes Relat Metab Disord 17, 31–36.