Skip to main content Accessibility help
×
Home

The effect of different dietary fatty acids on lipoprotein metabolism: concentration-dependent effects of diets enriched in oleic, myristic, palmitic and stearic acids

  • Andrew M. Salter (a1), E. Heather Mangiapane (a1), Andrew J. Bennett (a2), Jennifer S. Bruce (a1), Michael A. Billett (a2), Kay L. Anderton (a2), Christine B. Marenah (a3), Nigel Lawson (a3) and David A. White (a2)...

Abstract

While it is well established that the fatty acid composition of dietary fat is important in determining plasma lipoprotein cholesterol concentrations, the effects of changing the absolute quantities of the individual fatty acids are less clear. In the present study Golden Syrian hamsters were fed on isoenergetic, low cholesterol (0·05 g/kg) diets containing 100, 150 or 200 g added fat/kg. This consisted of triolein (TO) alone, or equal proportions of TO and either trimyristin (TM), tripalmitin (TP) or tristearin (TS). Each trial also included a control group fed on a diet containing 50g TO/kg. As the mass of TO in the diet increased, plasma VLDL-cholesterol concentrations rose. The TM-rich diets produced a concentration-dependent increase in total plasma cholesterol which was a result of significant increases in both VLDL and HDL levels. The TP-rich diets increased plasma LDL- and HDL-cholesterol levels in a concentration-dependent manner. TS-containing diets did not increase the cholesterol content of any of the major lipoprotein fractions. Hepatic LDL-receptor mRNA concentrations were significantly decreased in animals fed on TP, while apolipoprotein B mRNA concentrations were significantly increased. Thus, on a low-cholesterol diet, increasing the absolute amount of dietary palmitic acid increases LDL-cholesterol more than either myristic or stearic acid. These effects on lipoprotein metabolism may be exerted through specific modulation of the expression of the LDL receptor and apolipoprotein B genes.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The effect of different dietary fatty acids on lipoprotein metabolism: concentration-dependent effects of diets enriched in oleic, myristic, palmitic and stearic acids
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      The effect of different dietary fatty acids on lipoprotein metabolism: concentration-dependent effects of diets enriched in oleic, myristic, palmitic and stearic acids
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      The effect of different dietary fatty acids on lipoprotein metabolism: concentration-dependent effects of diets enriched in oleic, myristic, palmitic and stearic acids
      Available formats
      ×

Copyright

Corresponding author

*Corresponding author:Dr A. M. Salter, fax + 44 (0)115 951 6122, email Andrew.Salter@Nottingham.ac.uk

References

Hide All
Amri, E, Ailhaud, G & Grimaldi, P-A (1994) Fatty acids as signal transducing molecules–involvement in the differentiation of preadipose to adipose cells. Journal of Lipid Research 35, 930937.
Bennett, AJ, Billett, MA, Salter, AM, Mangiapane, EH, Bruce, JS, Anderton, KL, Marenah, CB, Lawson, N & White, DA (1995 a) Modulation of hepatic apolipoprotein B, 3-hydroxy-3-methyl-glutaryl-CoA reductase and low density lipoprotein receptor mRNA and plasma lipoprotein concentrations by defined dietary fats. Biochemical Journal 311, 167173.
Bennett, AJ, Billett, MA, Salter, AM & White, DA (1995 b) Regulation of hamster hepatic microsomal triglyceride transfer protein mRNA levels by dietary fats. Biochemical and Biophysical Research Communications 212, 473478.
Bonanome, A & Grundy, SM (1988) Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. New England Journal of Medicine 318, 12441248.
Bruce, JS & Salter, AM (1996) Metabolic fate of oleic acid, palmitic acid and stearic acid in cultured hamster hepatocytes. Biochemical Journal 316, 847852.
Chomczynski, P & Sacchi, N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 62, 156159.
Denke, MA & Grundy, SM (1991) Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men. American Journal of Clinical Nutrition 54, 10361040.
Denke, MA & Grundy, SM (1992) Comparison of effects of lauric acid and palmitic acid on plasma lipids. American Journal of Clinical Nutrition 56, 895898.
Derr, J, Kris-Etherton, PM, Pearson, TA & Seligson, FH (1993) The role of fatty acid saturation on plasma lipids, lipoproteins and apolipoproteins: II. The plasma total and low-density lipoprotein cholesterol response to individual fatty acids. Metabolism 42, 130134.
Emken, EA (1994) Metabolism of dietary stearic acid relative to other fatty acids in human subjects. American Journal of Clinical Nutrition 60, 1023S1028S.
Gearing, KL, Gottlicher, M, Widmark, E, Banner, CD, Tollet, P, Stromstedt, M, Rafter, JJ, Berge, RK & Gustafsson, J-A (1994) Fatty acid activation of the peroxisome proliferator activated receptor, a member of the nuclear receptor gene superfamily. Journal of Nutrition 124, 1284S1288S.
Goodman, DS, Deykin, D & Shiratori, T (1964) The formation of cholesterol esters with rat liver enzymes. Journal of Biological Chemistry 239, 13351345.
Grundy, SM & Denke, MA (1990) Dietary influences on serum lipids. Journal of Lipid Research 31, 11491172.
Harley, CB (1987) Hybridisation of oligo(dT) to RNA on nitrocellulose. Gene Analysis Techniques 4, 1722.
Hegsted, DM, McGandy, RB, Myers, ML & Stare, FJ (1965) Quantitative effects of dietary fat on serum cholesterol in man. American Journal of Clinical Nutrition 17, 281295.
Imaizumi, K, Abe, K, Kuroiwa, C & Sugano, M (1993) Fat containing stearic acid increases fecal neutral steroid excretion and catabolism of low density lipoproteins without affecting plasma cholesterol concentration in hamsters fed a cholesterol containing diet. Journal of Nutrition 123, 16931702.
Jump, DB, Clarke, SD, Thelen, A & Liimatta, M (1994) Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. Journal of Lipid Research 35, 10761084.
Keys, A, Anderson, JT & Grande, F (1965) Serum cholesterol response to changes in diet. IV. Particular saturated fatty acids in the diet. Metabolism 14, 776787.
Kurushima, H, Hayashi, K, Toyota, Y, Kambe, M & Kajiyama, G (1995) Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters. Atherosclerosis 114, 213221.
Lin, MCM, Arbeeny, C, Bergquist, K, Kienzle, B, Gordon, DA & Wetterau, JR (1994) Cloning and regulation of hamster microsomal triglyceride transfer protein. Journal of Biological Chemistry 269, 2913829145.
Mensink, RP & Katan, MB (1992) Effects of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arteriosclerosis and Thrombosis 12, 911919.
Stein, Y, Dabach, Y, Hollander, G & Stein, O (1990) Cholesterol ester transfer activity in hamster plasma: increase by fat and cholesterol rich diets. Biochimica et Biophysica Acta 1042, 138141.
Stucchi, AF, Hennessy, LK, Vespa, DB, Weiner, EJ, Osada, J, Ordovas, JM, Schaefer, EJ & Nicolosi, RJ (1991) Effect of corn and coconut-oil containing diets with and without cholesterol on high density lipoprotein apoprotein A-I and hepatic apoprotein A-I mRNA levels in cebus monkeys. Arteriosclerosis and Thrombosis 11, 17191729.
Sundram, K, Hayes, KC & Siru, OH (1994) Dietary palmitic acid results in lower serum cholesterol than does a lauric-myristic acid combination in normolipemic humans. American Journal of Clinical Nutrition 59, 841846.
Tholstrup, T, Marckmann, P, Jespersen, J & Sandström, B (1994 a) Fat high in stearic acid favorably affects blood lipids and factor VII coagulant activity in comparison with fats high in palmitic acid or high in myristic and lauric acids. American Journal of Clinical Nutrition 59, 371377.
Tholstrup, T, Marckmann, P, Jespersen, J, Vessby, B, Jart, A & Sandström, B (1994 b) Effect on blood lipids, coagulation, and fibrinolysis of a fat high in myristic acid and a fat high in palmitic acid. American Journal of Clinical Nutrition 60, 919925.
Woollett, LA, Spady, DK & Dietschy, JM (1992) Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate. Journal of Lipid Research 33, 7788.
Yu, S, Derr, J, Etherton, TJ & Kris-Etherton, PM (1995) Plasma cholesterol-predictive equations demonstrate that stearic acid is neutral and monounsaturated fatty acids are hypocholesterolemic. American Journal of Clinical Nutrition 61, 11291139.
Zock, PL, de Vries, JHM & Katan, MJ (1994) Impact of myristic acid versus palmitic acid on serum lipid and lipoprotein levels in healthy women and men. Arteriosclerosis and Thrombosis 14, 567575.
Zuckerman, SH & Evans, GF (1995) Cholesterol ester transfer protein inhibition in hypercholesterolemic hamsters – kinetics of apoprotein changes. Lipids 30, 307311.

Keywords

The effect of different dietary fatty acids on lipoprotein metabolism: concentration-dependent effects of diets enriched in oleic, myristic, palmitic and stearic acids

  • Andrew M. Salter (a1), E. Heather Mangiapane (a1), Andrew J. Bennett (a2), Jennifer S. Bruce (a1), Michael A. Billett (a2), Kay L. Anderton (a2), Christine B. Marenah (a3), Nigel Lawson (a3) and David A. White (a2)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed