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Differences in fatty acid composition between cerebral brain lobes in juvenile pigs after fish oil feeding

  • Carla Dullemeijer (a1) (a2), Peter L. Zock (a3), Ruben Coronel (a4), Hester M. Den Ruijter (a4), Martijn B. Katan (a5), Robert-Jan M. Brummer (a1), Frans J. Kok (a2), Jet Beekman (a6) and Ingeborg A. Brouwer (a1) (a2) (a5)...

Abstract

Very long-chain n-3 PUFA from fish are suggested to play a role in the development of the brain. Fish oil feeding results in higher proportions of n-3 PUFA in the brains of newborn piglets. However, the effect of fish oil on the fatty acid composition of specific cerebral brain lobes in juvenile pigs is largely uninvestigated. This study examined the effect of a fish oil diet on the fatty acid composition of the frontal, parietal, temporal and occipital brain lobes in juvenile pigs (7 weeks old). Pigs were randomly allocated to a semipurified pig diet containing either 4 % (w/w) fish oil (n 19) or 4 % (w/w) high-oleic acid sunflower oil (HOSF diet, n 18) for a period of 8 weeks. The fish oil diet resulted in significantly higher proportions (%) of DHA in the frontal (10·6 (sd1·2)), parietal (10·2 (sd1·5)) and occipital brain lobes (9·9 (sd 1·3)), but not in the temporal lobe (7·7 (sd1·6)), compared with pigs fed the HOSF diet (frontal lobe, 7·5 (sd1·0); parietal lobe, 8·1 (sd 1·3); occipital lobe, 7·3 (sd1·2), temporal lobe, 6·6 (sd1·2). Moreover, the proportion of DHA was significantly lower in the temporal lobe compared with the frontal, parietal and occipital brain lobes in pigs fed a fish oil diet. In conclusion, the brains of juvenile pigs appear to be responsive to dietary fish oil, although the temporal brain lobe is less responsive compared with the other three brain lobes. The functional consequences of these differences are a challenging focus for future investigation.

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Corresponding author

*Corresponding author: Carla Dullemeijer, fax +31 317 483342, email Carla.Dullemeijer@wur.nl

References

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1Sastry, PS (1985) Lipids of nervous tissue: composition and metabolism. Prog Lipid Res 24, 69176.
2Innis, SM (2007) Dietary (n-3) fatty acids and brain development. J Nutr 137, 855859.
3Heird, WC & Lapillonne, A (2005) The role of essential fatty acids in development. Annu Rev Nutr 25, 549571.
4Eilander, A, Hundscheid, DC, Osendarp, SJ, Transler, C & Zock, PL (2007) Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: A review of human studies. Prostaglandins Leukot Essent Fatty Acids 76, 189203.
5McCann, JC & Ames, BN (2005) Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr 82, 281295.
6Dobbing, J & Sands, J (1979) Comparative aspects of the brain growth spurt. Early Hum Dev 3, 7983.
7Duhaime, AC (2006) Large animal models of traumatic injury to the immature brain. Dev Neurosci 28, 380387.
8Arbuckle, LD, Rioux, FM, Mackinnon, MJ, Hrboticky, N & Innis, SM (1991) Response of (n-3) and (n-6) fatty acids in piglet brain, liver and plasma to increasing, but low, fish oil supplementation of formula. J Nutr 121, 15361547.
9Arbuckle, LD & Innis, SM (1992) Docosahexaenoic acid in developing brain and retina of piglets fed high or low alpha-linolenate formula with and without fish oil. Lipids 27, 8993.
10de la Presa Owens, S & Innis, SM (1999) Docosahexaenoic and arachidonic acid prevent a decrease in dopaminergic and serotoninergic neurotransmitters in frontal cortex caused by a linoleic and alpha-linolenic acid deficient diet in formula-fed piglets. J Nutr 129, 20882093.
11Morris, SA, Simmer, KN, van Barneveld, R & Gibson, RA (1999) Developmental sensitivity of the piglet brain to docosahexanoic acid. Pediatr Res 46, 401405.
12Rioux, FM, Innis, SM, Dyer, R & MacKinnon, M (1997) Diet-induced changes in liver and bile but not brain fatty acids can be predicted from differences in plasma phospholipid fatty acids in formula- and milk-fed piglets. J Nutr 127, 370377.
13Wall, KM, Diersen-Schade, D & Innis, SM (1994) Plasma and tissue lipids of piglets fed formula containing saturated fatty acids from medium-chain triglycerides with or without fish oil. Am J Clin Nutr 59, 13171324.
14Foote, KD, Hrboticky, N, MacKinnon, MJ & Innis, SM (1990) Brain synaptosomal, liver, plasma, and red blood cell lipids in piglets fed exclusively on a vegetable-oil-containing formula with and without fish-oil supplements. Am J Clin Nutr 51, 10011006.
15Jimenez, J, Boza, J, Suarez, MD & Gil, A (1997) The effect of a formula supplemented with n-3 and n-6 long-chain polyunsaturated fatty acids on plasma phospholipid, liver microsomal, retinal, and brain fatty acid composition in neonatal piglets. Nutr Biochem 8, 217223.
16Lapillonne, A, DeMar, JC, Nannegari, V & Heird, WC (2002) The fatty acid profile of buccal cheek cell phospholipids is a noninvasive marker of long-chain polyunsaturated fatty acid status in piglets. J Nutr 132, 23192323.
17Goustard-Langelier, B, Guesnet, P, Durand, G, Antoine, JM & Alessandri, JM (1999) n-3 and n-6 fatty acid enrichment by dietary fish oil and phospholipid sources in brain cortical areas and nonneural tissues of formula-fed piglets. Lipids 34, 516.
18Dickerson, JWT & Dobbing, J (1967) Prenatal and postnatal growth and development of the central nervous system of the pig. Proc R Soc (B) 166, 384395.
19Rice, D & Barone, S Jr (2000) Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect 108, Suppl. 3, 511533.
20Smith, EE & Jonides, J (1999) Storage and executive processes in the frontal lobes. Science 283, 16571661.
21Culham, JC & Valyear, KF (2006) Human parietal cortex in action. Curr Opin Neurobiol 16, 205212.
22Squire, LR, Stark, CE & Clark, RE (2004) The medial temporal lobe. Annu Rev Neurosci 27, 279306.
23Grill-Spector, K, Kourtzi, Z & Kanwisher, N (2001) The lateral occipital complex and its role in object recognition. Vision Res 41, 14091422.
24National Research Council (1996) Guide for the Care and Use of Laboratory Animals. Publication no. 85-23, revised. Washington, Dc: National Acadmy Press.
25Coronel, R, Wilms-Schopman, FJ, Den Ruijter, HM, et al. (2007) Dietary n-3 fatty acids promote arrhythmias during acute regional myocardial ischemia in isolated pig hearts. Cardiovasc Res 73, 386394.
26Folch, J, Lees, M & Sloane Stanley, GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226, 497509.
27Weihrauch, JL, Posati, LP, Anderson, BA & Exler, J (1977) Lipid conversion factors for calculating fatty acid contents of foods. J Am Oil Chem Soc 54, 3640.
28Svennerholm, L (1968) Distribution and fatty acid composition of phosphoglycerides in normal human brain. J Lipid Res 9, 570579.
29Martinez, M (1992) Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr 120, S129S138.
30O'Brien, JS & Sampson, EL (1965) Fatty acid and fatty aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin. J Lipid Res 6, 545551.
31Blank, C, Neumann, MA, Makrides, M & Gibson, RA (2002) Optimizing DHA levels in piglets by lowering the linoleic acid to alpha-linolenic acid ratio. J Lipid Res 43, 15371543.
32Levant, B, Ozias, MK, Jones, KA & Carlson, SE (2006) Differential effects of modulation of docosahexaenoic acid content during development in specific regions of rat brain. Lipids 41, 407414.
33Gogtay, N, Giedd, JN, Lusk, L, et al. (2004) Dynamic mapping of human cortical development during childhood through early adulthood. Proc Nat Acad Sci U S A 101, 81748179.
34Kennepohl, S, Sziklas, V, Garver, KE, Wagner, DD & Jones-Gotman, M (2007) Memory and the medial temporal lobe: Hemispheric specialization reconsidered. Neuroimage 36, 969978.
35Qi, K, Hall, M & Deckelbaum, RJ (2002) Long-chain polyunsaturated fatty acid accretion in brain. Curr Opin Clin Nutr Metab Care 5, 133138.
36Hamilton, JA & Kamp, F (1999) How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids? Diabetes 48, 22552269.
37Glatz, JF, van Nieuwenhoven, FA, Luiken, JJ, Schaap, FG & van der Vusse, GJ (1997) Role of membrane-associated and cytoplasmic fatty acid-binding proteins in cellular fatty acid metabolism. Prostaglandins Leukot Essent Fatty Acids 57, 373378.
38Flynn, TJ (1984) Developmental changes of myelin-related lipids in brain of miniature swine. Neurochem Res 9, 935945.

Keywords

Differences in fatty acid composition between cerebral brain lobes in juvenile pigs after fish oil feeding

  • Carla Dullemeijer (a1) (a2), Peter L. Zock (a3), Ruben Coronel (a4), Hester M. Den Ruijter (a4), Martijn B. Katan (a5), Robert-Jan M. Brummer (a1), Frans J. Kok (a2), Jet Beekman (a6) and Ingeborg A. Brouwer (a1) (a2) (a5)...

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