Skip to main content Accessibility help
×
Home

Dietary inflammatory index and memory function: population-based national sample of elderly Americans

  • Emily Frith (a1), Nitin Shivappa (a2) (a3), Joshua R. Mann (a4), James R. Hébert (a2) (a3), Michael D. Wirth (a2) (a3) (a5) and Paul D. Loprinzi (a1)...
  • Please note a correction has been issued for this article.

Abstract

The objective of this study was to examine the association between dietary inflammatory potential and memory and cognitive functioning among a representative sample of the US older adult population. Cross-sectional data from the 2011–2012 and 2013–2014 National Health and Nutrition Examination Survey were utilised to identify an aggregate sample of adults 60–85 years of age (n 1723). Dietary inflammatory index (DII®) scores were calculated using 24-h dietary recall interviews. Three memory-related assessments were employed, including the Consortium to Establish a Registry for Alzheimer’s disease (CERAD) Word Learning subset, the Animal Fluency test and the Digit Symbol Substitution Test (DSST). Inverse associations were observed between DII scores and the different memory parameters. Episodic memory (CERAD) (b adjusted=−0·39; 95 % CI −0·79, 0·00), semantic-based memory (Animal Fluency Test) (b adjusted=−1·18; 95 % CI −2·17, −0·20) and executive function and working-memory (DSST) (b adjusted=−2·80; 95 % CI −5·58, −0·02) performances were lowest among those with the highest mean DII score. Though inverse relationships were observed between DII scores and memory and cognitive functioning, future work is needed to further explore the neurobiological mechanisms underlying the complex relationship between inflammation-related dietary behaviour and memory and cognition.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Dietary inflammatory index and memory function: population-based national sample of elderly Americans
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Dietary inflammatory index and memory function: population-based national sample of elderly Americans
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Dietary inflammatory index and memory function: population-based national sample of elderly Americans
      Available formats
      ×

Copyright

Corresponding author

* Corresponding author: P. D. Loprinzi, fax +1 662 915 5525, email pdloprin@olemiss.edu

References

Hide All
1. Carpenter, PA, Just, MA & Reichle, ED (2000) Working memory and executive function: evidence from neuroimaging. Curr Opin Neurobiol 10, 195199.
2. Mazoyer, B, Zago, L, Mellet, E, et al. (2001) Cortical networks for working memory and executive functions sustain the conscious resting state in man. Brain Res Bull 54, 287298.
3. McCabe, DP, Roediger, HL, McDaniel, MA, et al. (2010) The relationship between working memory capacity and executive functioning: evidence for a common executive attention construct. Neuropsychology 24, 222243.
4. Posner, MI & DiGirolamo, GJ (1998) Executive attention: conflict, target detection, and cognitive control. In The Attentive Brain, pp. 401423 [R Parasuraman, editor]. Cambridge, MA: MIT Press.
5. Glass, JM, Buu, A, Adams, KM, et al. (2009) Effects of alcoholism severity and smoking on executive neurocognitive function. Addiction 104, 3848.
6. Slotnick, SD (2017) Types of memory and brain regions of interest. In Cognitive Neuroscience of Memory, p. 5 [SD Slotnick, editor]. New York: Cambridge University Press.
7. Eichenbaum, H (2012) The Cognitive Neuroscience of Memory: An Introduction . New York: Oxford University Press.
8. Hantke, N, Nielson, KA, Woodard, JL, et al. (2013) Comparison of semantic and episodic memory BOLD fMRI activation in predicting cognitive decline in older adults. J Int Neuropsychol Soc 19, 1121.
9. Bruce-Keller, AJ, Keller, JN & Morrison, CD (2009) Obesity and vulnerability of the CNS. Biochim Biophys Acta 1792, 395400.
10. Kanoski, SE & Davidson, TL (2011) Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiol Behav 103, 5968.
11. Okubo, H, Inagaki, H, Gondo, Y, et al. (2017) Association between dietary patterns and cognitive function among 70-year-old Japanese elderly: a cross-sectional analysis of the SONIC study. Nutr J 16, 56.
12. Chan, R, Chan, D & Woo, J (2013) A cross sectional study to examine the association between dietary patterns and cognitive impairment in older Chinese people in Hong Kong. J Nutr Health Aging 17, 757765.
13. Anastasiou, CA, Yannakoulia, M, Kosmidis, MH, et al. (2017) Mediterranean diet and cognitive health: initial results from the Hellenic Longitudinal Investigation of Ageing and Diet. PLOS ONE 12, e0182048.
14. Titova, OE, Ax, E, Brooks, SJ, et al. (2013) Mediterranean diet habits in older individuals: associations with cognitive functioning and brain volumes. Exp Gerontol 48, 14431448.
15. Coppin, G, Nolan-Poupart, S, Jones-Gotman, M, et al. (2014) Working memory and reward association learning impairments in obesity. Neuropsychologia 65, 146155.
16. Kanoski, SE & Davidson, TL (2010) Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet. J Exp Psychol Anim Behav Process 36, 313319.
17. Jiang, X, Huang, J, Song, D, et al. (2017) Increased consumption of fruit and vegetables is related to a reduced risk of cognitive impairment and dementia: meta-analysis. Front Aging Neurosci 9, 18.
18. Hayden, KM, Beavers, DP, Steck, SE, et al. (2017) The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women’s Health Initiative Memory Study. Alzheimer’s Dement 13, 11871196.
19. Kesse-Guyot, E, Assmann, KE, Andreeva, VA, et al. (2017) Long-term association between the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study. Eur J Nutr 56, 16471655.
20. Nyberg, L, Backman, L, Erngrund, K, et al. (1996) Age differences in episodic memory, semantic memory, and priming: relationships to demographic, intellectual, and biological factors. J Gerontol Series B Psychol Sci Soc Sci 51, P234P240.
21. US National Center for Health Statistics (1994) Plan and Operation of the Third National Health and Nutrition Examination Survey, 1988–94. Hyattsville, MD, Washington, DC: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention.
22. Shivappa, N, Steck, SE, Hurley, TG, et al. (2014) Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr 17, 16891696.
23. Shivappa, N, Steck, SE, Hurley, TG, et al. (2014) A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS). Public Health Nutr 17, 18251833.
24. Tabung, FK, Steck, SE, Zhang, J, et al. (2015) Construct validation of the dietary inflammatory index among postmenopausal women. Ann Epidemiol 25, 398405.
25. Wirth, MD, Shivappa, N., Davis, L, et al. (2017) Construct validation of the dietary inflammatory index among African Americans. J Nutr Health Aging 21, 487491.
26. Wirth, MD, Burch, J, Shivappa, N, et al. (2014) Association of a dietary inflammatory index with inflammatory indices and metabolic syndrome among police officers. J Occup Environ Med 56, 986989.
27. Ramallal, R, Toledo, E, Martinez-Gonzalez, MA, et al. (2015) Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the SUN Cohort. PLOS ONE 10, e0135221.
28. Morris, JC, Heyman, A, Mohs, RC, et al. (1989) The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer’s disease. Neurology 39, 11591165.
29. Fillenbaum, GG, van Belle, G, Morris, JC, et al. (2008) Consortium to Establish a Registry for Alzheimer’s Disease (CERAD): the first twenty years. Alzheimers Dement 4, 96109.
30. Gao, S, Jin, Y, Unverzagt, FW, et al. (2009) Hypertension and cognitive decline in rural elderly Chinese. J Am Geriatr Soc 57, 10511057.
31. Lee, DY, Lee, KU, Lee, JH, et al. (2004) A normative study of the CERAD neuropsychological assessment battery in the Korean elderly. J Int Neuropsychol Soc 10, 7281.
32. Prince, M, Acosta, D, Chiu, H, et al. (2003) Dementia diagnosis in developing countries: a cross-cultural validation study. Lancet 361, 909917.
33. Ramirez-Gomez, L, Zheng, L, Reed, B, et al. (2017) Neuropsychological profiles differentiate Alzheimer disease from subcortical ischemic vascular dementia in an autopsy-defined cohort. Dement Geriatr Cogn Disord 44, 111.
34. Tuokko, H, Griffith, LE, Simard, M, et al. (2017) Cognitive measures in the Canadian Longitudinal Study on Aging. Clin Neuropsychol 31, 233250.
35. Clark, LJ, Gatz, M, Zheng, L, et al. (2009) Longitudinal verbal fluency in normal aging, preclinical, and prevalent Alzheimer’s disease. Am J Alzheimers Dis Other Demen 24, 461468.
36. Canning, SJ, Leach, L, Stuss, D, et al. (2004) Diagnostic utility of abbreviated fluency measures in Alzheimer disease and vascular dementia. Neurology 62, 556562.
37. Grundman, M, Petersen, RC, Ferris, SH, et al. (2004) Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol 61, 5966.
38. Duff, K, Schoenberg, MR, Scott, JG, et al. (2005) The relationship between executive functioning and verbal and visual learning and memory. Arch Clin Neuropsychol 20, 111122.
39. Wechsler, D (1958) The Measurement and Appraisal of Adult Intelligence, vol. 33. Baltimore, MD: Williams & Wilkins Co.
40. Bienias, JL, Beckett, LA, Bennett, DA, et al. (2003) Design of the Chicago Health and Aging Project (CHAP). J Alzheimers Dis 5, 349355.
41. Plassman, BL, Langa, KM, Fisher, GG, et al. (2007) Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology 29, 125132.
42. Proust-Lima, C, Amieva, H, Dartigues, JF, et al. (2007) Sensitivity of four psychometric tests to measure cognitive changes in brain aging-population-based studies. Am J Epidemiol 165, 344350.
43. Vilkki, J & Holst, P (1991) Mental programming after frontal lobe lesions: results on digit symbol performance with self-selected goals. Cortex 27, 203211.
44. Parkin, AJ & Java, RI (1999) Deterioration of frontal lobe function in normal aging: influences of fluid intelligence versus perceptual speed. Neuropsychology 13, 539545.
45. Cleland, CL, Hunter, RF, Kee, F, et al. (2014) Validity of the global physical activity questionnaire (GPAQ) in assessing levels and change in moderate-vigorous physical activity and sedentary behaviour. BMC Public Health 14, 1255.
46. Bull, FC, Maslin, TS & Armstrong, T (2009) Global physical activity questionnaire (GPAQ): nine country reliability and validity study. J Phys Act Health 6, 790804.
47. Freeman, LR, Haley-Zitlin, V, Rosenberger, DS, et al. (2014) Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms. Nutr Neurosci 17, 241251.
48. Volkow, ND, Wang, GJ & Baler, RD (2011) Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn Sci 15, 3746.
49. Higgs, S (2016) Cognitive processing of food rewards. Appetite 104, 1017.
50. Epstein, LH, Temple, JL, Roemmich, JN, et al. (2009) Habituation as a determinant of human food intake. Psychol Rev 116, 384407.
51. Hebben, N, Corkin, S, Eichenbaum, H, et al. (1985) Diminished ability to interpret and report internal states after bilateral medial temporal resection: case H.M. Behav Neurosci 99, 10311039.
52. Scoville, WB & Milner, B (1957) Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 20, 1121.
53. Higgs, S (2008) Cognitive influences on food intake: the effects of manipulating memory for recent eating. Physiol Behav 94, 734739.
54. Klein, C, Jonas, W, Iggena, D, et al. (2016) Exercise prevents high-fat diet-induced impairment of flexible memory expression in the water maze and modulates adult hippocampal neurogenesis in mice. Neurobiol Learn Mem 131, 2635.
55. Francis, H & Stevenson, R (2013) The longer-term impacts of Western diet on human cognition and the brain. Appetite 63, 119128.
56. Holloway, CJ, Cochlin, LE, Emmanuel, Y, et al. (2011) A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects. Am J Clin Nutr 93, 748755.
57. Volkow, ND, Wang, GJ, Telang, F, et al. (2009) Inverse association between BMI and prefrontal metabolic activity in healthy adults. Obesity 17, 6065.
58. Francis, HM & Stevenson, RJ (2011) Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals. Behav Neurosci 125, 943955.
59. Davidson, TL (1993) The nature and function of interoceptive signals to feed: toward integration of physiological and learning perspectives. Psychol Rev 100, 640657.
60. Kennedy, PJ & Shapiro, ML (2004) Retrieving memories via internal context requires the hippocampus. J Neurosci 24, 69796985.
61. Davidson, TL, Kanoski, SE, Walls, EK, et al. (2005) Memory inhibition and energy regulation. Physiol Behav 86, 731746.
62. Nyberg, L, Cabeza, R & Tulving, E (1996) PET studies of encoding and retrieval: The HERA model. Psychon Bull Rev 3, 135148.
63. Nader, K (2003) Memory traces unbound. Trends Neurosci 26, 6572.
64. Loprinzi, PD, Edwards, MK & Frith, E (2017) Potential avenues for exercise to activate episodic memory-related pathways: a narrative review. Eur J Neurosci 46, 20672077.
65. Gunstad, J, Paul, RH, Cohen, RA, et al. (2007) Elevated body mass index is associated with executive dysfunction in otherwise healthy adults. Compr Psychiatry 48, 5761.
66. Cohen, P, Levy, JD, Zhang, Y, et al. (2014) Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 156, 304316.
67. Hao, S, Dey, A, Yu, X, et al. (2016) Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity. Brain Behav Immun 51, 230239.
68. Murray, CA & Lynch, MA (1998) Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation. J Neurosci 18, 29742981.
69. Cunningham, ET Jr., Wada, E, Carter, DB, et al. (1992) In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse. J Neurosci 12, 11011114.
70. Plata-Salaman, CR & ffrench-Mullen, JM (1994) Interleukin-1 beta inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C. Eur J Pharmacol 266, 110.
71. Rada, P, Mark, GP, Vitek, MP, et al. (1991) Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats. Brain Res 550, 287290.
72. Huang, KF, Huang, WT, Lin, KC, et al. (2010) Interleukin-1 receptor antagonist inhibits the release of glutamate, hydroxyl radicals, and prostaglandin E(2) in the hypothalamus during pyrogen-induced fever in rabbits. Eur J Pharmacol 629, 125131.
73. Murray, CA, McGahon, B, McBennett, S, et al. (1997) Interleukin-1 beta inhibits glutamate release in hippocampus of young, but not aged, rats. Neurobiol Aging 18, 343348.
74. Liu, X, Wu, Z, Hayashi, Y, et al. (2012) Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation. Neuroscience 216, 133142.
75. Johnson, PM & Kenny, PJ (2010) Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci 13, 635641.
76. Jay, TM (2003) Dopamine: a potential substrate for synaptic plasticity and memory mechanisms. Prog Neurobiol 69, 375390.
77. Frey, U, Matthies, H, Reymann, KG, et al. (1991) The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro. Neurosci Lett 129, 111114.
78. Frey, U, Schroeder, H & Matthies, H (1990) Dopaminergic antagonists prevent long-term maintenance of posttetanic LTP in the CA1 region of rat hippocampal slices. Brain Res 522, 6975.
79. Lynch, MA (2004) Long-term potentiation and memory. Physiol Rev 84, 87136.

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

A correction has been issued for this article: