1 Touchette, KJ, Carroll, JA, Allee, GL, Matteri, RL, Dyer, CJ, Beausang, LA & Zannelli, ME (2002) Effect of spray-dried plasma and lipopolysaccharide exposure on weaned pigs: I. Effects on the immune axis of weaned pigs. J Anim Sci 80, 494–501.
2 Pié, S, Lallès, JP, Blazy, F, Laffitte, J, Sève, B & Oswald, IP (2004) Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets. J Nutr 134, 641–647.
3 Yi, GF, Carroll, JA, Allee, GL, Gaines, AM, Kendall, DC, Usry, JL, Toride, Y & Izuru, S (2005) Effect of glutamine and spray-dried plasma on growth performance, small intestinal morphology, and immune responses of Escherichia coli K88+-challenged weaned pigs. J Anim Sci 83, 634–643.
4 Blikslager, AT, Moeser, AJ, Gookin, JL, Jones, SL & Odle, J (2007) Restoration of barrier function in injured intestinal mucosa. Physiol Rev 87, 545–564.
5 Mckay, DM & Baird, AW (1999) Cytokine regulation of epithelial permeability and ion transport. Gut 44, 283–289.
6 Anggard, E (1994) Nitric oxide: mediator, murderer, and medicine. Lancet 14, 1199–1206.
7 Sukhotnik, I, Helou, H, Mogilner, J, Lurie, M, Bernsteyn, A, Coran, AG & Shiloni, E (2005) Oral arginine improves intestinal recovery following ischemia–reperfusion injury in rat. Pediatr Surg Int 21, 191–196.
8 Fu, TL, Zhang, WT, Zhang, L, Wang, F, Gao, Y & Xu, M (2005) l-Arginine administration ameliorates serum and pulmonary cytokine response after gut ischemia–reperfusion in immature rats. World J Gastroenterol 11, 1070–1072.
9 Duggan, C, Gannon, J & Walker, WA (2002) Protective nutrients and functional foods for the gastrointestinal tract. Am J Clin Nutr 75, 789–808.
10 Mercer, DW, Smith, GS, Cross, JM, Russell, DH, Chang, L & Cacioppo, J (1996) Effects of lipopolysaccharide on intestinal injury: potential role of nitric oxide and lipid peroxidation. J Surg Res 63, 185–192.
11 National Research Council (1998) Nutrient Requirements of Swine, 10th ed. Washington, DC: National Academy Press.
12 Association of Official Analytical Chemists (1990) Official Methods of Analysis, 15th ed. Washington, DC: AOAC.
13 Gurbuz, AT, Kunzelman, J & Ratzer, EE (1998) Supplemental dietary arginine accelerates intestinal mucosal regeneration and enhances bacterial clearance following radiation enteritis in rats. J Surg Res 74, 149–154.
14 Luna, LG (1968) Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology, 3rd ed. New York: McGraw-Hill Book Company.
15 Lowry, OH, Rosebrough, NJ, Farr, AL & Randall, RJ (1951) Protein measurement with Folin phenol reagent. J Biol Chem 193, 265–275.
16 Labarca, C & Paigen, K (1980) A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 1, 344–352.
17 Nabuurs, MJA, Hoogendoorn, A, van der Molen, EJ & van Osta, ALM (1993) Villus height and crypt depth in weaned and unweaned pigs, reared under various circumstances in the Netherlands. Res Vet Sci 55, 78–84.
18 Livak, KJ & Schmittgen, TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and 2− ΔΔCT method. Methods 25, 402–408.
19 VanderMeer, TJ, Wang, H & Fink, MP (1995) Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 23, 1217–1226.
20 Fink, MP, Antonsson, JB, Wang, HL & Rothschild, HR (1991) Increased intestinal permeability in endotoxic pigs. Mesenteric hypoperfusion as an etiologic factor. Arch Surg 126, 211–218.
21 Verdonk, JMAJ, Spreeuwenberg, MAM, Bakker, GCM & Verstegen, MWA (2001) Nutrient intake level affects histology and permeability of the small intestine in newly weaned piglets. In Digestive Physiology of Pigs, pp. 332–334 [Lindberg, JE and Ogle, B, editors]. Wallingford, UK: CABI Publishing.
22 Johnson, RW (1997) Inhibition of growth by proinflammatory cytokines: an intergrated view. J Anim Sci 75, 1244–1255.
23 Liu, YL, Li, DF, Gong, LM, Yi, GF, Gaines, AM & Carroll, JA (2003) Effects of fish oil supplementation on the performance and the immunological, adrenal, and somatotropic responses of weaned pigs after an Escherichia coli lipopolysaccharide challenge. J Anim Sci 81, 2758–2765.
24 Kim, SW, McPherson, RL & Wu, G (2004) Dietary arginine supplementation enhances the growth of milk-fed young pigs. J Nutr 134, 625–630.
25 Takahashi, K, Orihashi, M & Yukio, A (1999) Dietary l-arginine level alters plasma nitric oxide and apha-1 acid glycoprotein concentrations, and splenocyte proliferation in male broiler chickens following Escherichia coli lipopolysaccharide injection. Comp Biochem Physiol C Toxicol Pharmacol 124, 309–314.
26 Kohli, R, Meininger, CJ, Haynes, TE, Yan, W, Self, JT & Wu, G (2004) Dietary l-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats. J Nutr 134, 600–608.
27 Frank, JW, Escobar, J, Nguyen, HV, Jobgen, SC, Jobgen, WS, Davis, TA & Wu, G (2007) Oral N-carbamylglutamate supplementation increases protein synthesis in skeletal muscle of piglets. J Nutr 137, 315–319.
28 Wu, G, Meininger, CJ, Knabe, DA, Bazer, FW & Rhoads, JM (2000) Arginine nutrition in development, health and disease. Curr Opin Clin Nutr Metab Care 3, 59–66.
29 Sukumar, P, Loo, A, Magur, E, Nandi, J, Oler, A & Levine, RA (1997) Dietary supplementation of nucleotides and arginine promotes healing of small bowel ulcers in experimental ulcerative ileitis. Dig Dis Sci 42, 1530–1536.
30 Baker, DH (1982) Importance of amino acid balance in swine rations. Feedstuffs 54, 40.
31 Anderson, LC, Lewis, AJ, Peo, ER Jr & Crenshaw, JD (1984) Effects of excess arginine with and without supplemental lysine on performance, plasma amino acid concentrations and nitrogen balance of young swine. J Anim Sci 58, 369–377.
32 Rhoads, JM, Chen, W, Gookin, J, et al. (2004) Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism. Gut 53, 514–522.
33 Rhoads, JM, Niu, X, Odle, J & Graves, LM (2006) Role of mTOR signaling in intestinal cell migration. Am J Physiol Gastrointest Liver Physiol 291, G510–G517.
34 Oswald, IP, Dozois, CM, Barlagne, R, Fournout, S, Johansen, MV & Bogh, HO (2001) Cytokine mRNA expression in pigs infected with Schistosoma japonicum. Parasitology 122, 299–307.
35 Marion, R, Coëffier, M, Lemoulan, S, Gargala, G, Ducrotté, P & Déchelotte, P (2005) l-Arginine modulates CXC chemokines in the human intestinal epithelial cell line HCT-8 by the NO pathway. Biochimie 87, 1048–1055.
36 Cui, XL, Iwasa, M, Iwasa, Y & Ogoshi, S (2000) Arginine-supplemented diet decreases expression of inflammatory cytokines and improves survival in burned rats. JPEN J Parenter Enteral Nutr 24, 89–96.
37 Yeh, CL, Yeh, SL, Lin, MT & Chen, WJ (2002) Effects of arginine-enriched total parenteral nutrition on inflammatory-related mediator and T-cell population in septic rats. Nutrition 18, 631–635.
38 Nakajima, A, Wada, K, Miki, H, et al. (2001) Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia–reperfusion injury. Gastroenterology 120, 460–469.
39 Cuzzocrea, S, Pisano, B, Dugo, L, et al. (2003) Rosiglitazone and 5-deoxy-delta 12,14-prostaglandin J2, ligand of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut. Br J Pharmacol 140, 366–376.
40 Katayama, K, Wada, K, Nakajima, A, et al. (2003) A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model. Gastroenterology 124, 1315–1324.
41 Sato, N, Kozar, RA, Zou, L, Weatherall, JM, Attuwaybi, B, Moore-Olufemi, SD, Weisbrodt, NW & Moore, FA (2005) Peroxisome proliferator-activated receptor gamma mediates protection against cyclooxygenase-2-induced gut dysfunction in a rodent model of mesenteric ischemia/reperfusion. Shock 24, 462–469.
42 Moraes, LA, Piqueras, L & Bishop-Bailey, D (2006) Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther 110, 371–385.
43 Calkins, CM, Bensard, DD, Heimbach, JK, Meng, X, Shames, BD, Pulido, EJ & McIntyre, RC Jr (2001) l-Arginine attenuates lipopolysaccharide-induced lung chemokine production. Am J Physiol Lung Cell Mol Physiol 280, L400–L408.
44 Desreumaux, P, Dubuquoy, L, Nutten, S, et al. (2001) Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies. J Exp Med 193, 827–838.