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Diet and liver cancer risk: a narrative review of epidemiological evidence

  • Wan-Shui Yang (a1), Xu-Fen Zeng (a1), Zhi-Ning Liu (a2), Qi-Hong Zhao (a1), Yu-Ting Tan (a3), Jing Gao (a3), Hong-Lan Li (a3) and Yong-Bing Xiang (a3)...

Abstract

Primary liver cancer is the third leading cause of cancer-related death worldwide. Most patients are diagnosed at late stages with poor prognosis; thus, identification of modifiable risk factors for primary prevention of liver cancer is urgently needed. The well-established risk factors of liver cancer include chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV), heavy alcohol consumption, metabolic diseases such as obesity and diabetes, and aflatoxin exposure. However, a large proportion of cancer cases worldwide cannot be explained by current known risk factors. Dietary factors have been suspected as important, but dietary aetiology of liver cancer remains poorly understood. In this review, we summarised and evaluated the observational studies of diet including single nutrients, food and food groups, as well as dietary patterns with the risk of developing liver cancer. Although there are large knowledge gaps between diet and liver cancer risk, current epidemiological evidence supports an important role of diet in liver cancer development. For example, exposure to aflatoxin, heavy alcohol drinking and possibly dairy product (not including yogurt) intake increase, while intake of coffee, fish and tea, light-to-moderate alcohol drinking and several healthy dietary patterns (e.g. Alternative Healthy Eating Index) may decrease liver cancer risk. Future studies with large sample size and accurate diet measurement are warranted and need to consider issues such as the possible aetiological heterogeneity between liver cancer subtypes, the influence of chronic HBV or HCV infection, the high-risk populations (e.g. cirrhosis) and a potential interplay with host gut microbiota or genetic variations.

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Corresponding author

*Corresponding author: Professor Yong-Bing Xiang, email ybxiang@shsci.org

References

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1.Bray, F, Ferlay, J, Soerjomataram, I, et al. (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68, 394424.
2.Petrick, JL, Florio, AA, Znaor, A, et al. (2019) International trends in hepatocellular carcinoma incidence, 1978–2012. Int J Cancer (epublication ahead of print version 9 October 2019).
3.Mittal, S & El-Serag, HB (2013) Epidemiology of hepatocellular carcinoma: consider the population. J Clin Gastroenterol 47, S2S6.
4.Davis, GL, Dempster, J, Meler, JD, et al. (2008) Hepatocellular carcinoma: management of an increasingly common problem. Proc (Bayl Univ Med Cent) 21, 266280.
5.Yang, Y, Gao, J, Li, HL, et al. (2016) Dose–response association between hepatitis B surface antigen levels and liver cancer risk in Chinese men and women. Int J Cancer 139, 355362.
6.Yang, B, Petrick, JL, Kelly, SP, et al. (2017) Adiposity across the adult life course and incidence of primary liver cancer: the NIH-AARP cohort. Int J Cancer 141, 271278.
7.Aleksandrova, K, Stelmach-Mardas, M & Schlesinger, S (2016) Obesity and liver cancer. Recent Results Cancer Res 208, 177198.
8.Sun, B & Karin, M (2012) Obesity, inflammation, and liver cancer. J Hepatol 56, 704713.
9.Qian, Y & Fan, JG (2005) Obesity, fatty liver and liver cancer. Hepatobiliary Pancreat Dis Int 4, 173177.
10.Campbell, PT, Newton, CC, Freedman, ND, et al. (2016) Body mass index, waist circumference, diabetes, and risk of liver cancer for U.S. adults. Cancer Res 76, 60766083.
11.Liu, Y, Warren Andersen, S, Wen, W, et al. (2016) Prospective cohort study of general and central obesity, weight change trajectory and risk of major cancers among Chinese women. Int J Cancer 139, 14611470.
12.Petrick, JL, Freedman, ND, Demuth, J, et al. (2016) Obesity, diabetes, serum glucose, and risk of primary liver cancer by birth cohort, race/ethnicity, and sex: multiphasic health checkup study. Cancer Epidemiol 42, 140146.
13.Chen, Y, Wu, F, Saito, E, et al. (2017) Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium. Diabetologia 60, 10221032.
14.Zhu, Q, Shao, X, Chen, S, et al. (2018) Epidemiological serosurvey of hepatitis B virus among children aged 1–14 years in Guangdong Province, China. Int J Infect Dis 71, 2529.
15.Thrift, AP, El-Serag, HB & Kanwal, F (2017) Global epidemiology and burden of HCV infection and HCV-related disease. Nat Rev Gastroenterol Hepatol 14, 122132.
16.Ng, M, Fleming, T, Robinson, M, et al. (2014) Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384, 766781.
17.Wang, L, Gao, P, Zhang, M, et al. (2017) Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA 317, 25152523.
18.Makarova-Rusher, OV, Altekruse, SF, McNeel, TS, et al. (2016) Population attributable fractions of risk factors for hepatocellular carcinoma in the United States. Cancer 122, 17571765.
19.World Cancer Research Fund International/American Institute for Cancer Research (2018) Diet, Nutrition, Physical Activity and Liver Cancer, Continuous Update Project Expert Report 2018. London: World Cancer Research Fund International/American Institute for Cancer Research.
20.Ludwig, DS (2002) The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. Jama 287, 24142423.
21.Malaguarnera, R & Belfiore, A (2014) The emerging role of insulin and insulin-like growth factor signaling in cancer stem cells. Front Endocrinol 5, 10.
22.Shan, J, Shen, J, Liu, L, et al. (2012) Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma. Hepatology 56, 10041014.
23.Muto, Y, Sato, S, Watanabe, A, et al. (2006) Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis. Hepatol Res 35, 204214.
24.Iwasa, J, Shimizu, M, Shiraki, M, et al. (2010) Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. Cancer Sci 101, 460467.
25.Alexia, C, Fallot, G, Lasfer, M, et al. (2004) An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis. Biochem Pharmacol 68, 10031015.
26.Yu, LX & Schwabe, RF (2017) The gut microbiome and liver cancer: mechanisms and clinical translation. Nat Rev Gastroenterol Hepatol 14, 527539.
27.Gupta, H, Youn, GS, Shin, MJ, et al. (2019) Role of gut microbiota in hepatocarcinogenesis. Microorganisms 7, E121.
28.Chu, YJ, Yang, HI, Wu, HC, et al. (2017) Aflatoxin B1 exposure increases the risk of cirrhosis and hepatocellular carcinoma in chronic hepatitis B virus carriers. Int J Cancer 141, 711720.
29.Chu, YJ, Yang, HI, Wu, HC, et al. (2018) Aflatoxin B1 exposure increases the risk of hepatocellular carcinoma associated with hepatitis C virus infection or alcohol consumption. Eur J Cancer 94, 3746.
30.Bleich, SN, Wang, YC, Wang, Y, et al. (2009) Increasing consumption of sugar-sweetened beverages among US adults: 1988–1994 to 1999–2004. Am J Clin Nutr 89, 372381.
31.Rebollo, A, Roglans, N, Alegret, M, et al. (2012) Way back for fructose and liver metabolism: bench side to molecular insights. World J Gastroenterol 18, 65526559.
32.Vila, L, Roglans, N, Perna, V, et al. (2011) Liver AMP/ATP ratio and fructokinase expression are related to gender differences in AMPK activity and glucose intolerance in rats ingesting liquid fructose. J Nutr Biochem 22, 741751.
33.Roglans, N, Vila, L, Farre, M, et al. (2007) Impairment of hepatic Stat-3 activation and reduction of PPARalpha activity in fructose-fed rats. Hepatology 45, 778788.
34.Li, JM, Li, YC, Kong, LD, et al. (2010) Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology 51, 15551566.
35.Rebollo, A, Roglans, N, Baena, M, et al. (2014) Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells. Biochim Biophys Acta 1841, 514524.
36.Laguna, JC, Alegret, M & Roglans, N (2014) Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight. Nutrients 6, 59335954.
37.Gaesser, GA (2007) Carbohydrate quantity and quality in relation to body mass index. J Am Diet Assoc 107, 17681780.
38.Lau, C, Faerch, K, Glumer, C, et al. (2005) Dietary glycemic index, glycemic load, fiber, simple sugars, and insulin resistance: the Inter99 study. Diabet Care 28, 13971403.
39.Valtuena, S, Pellegrini, N, Ardigo, D, et al. (2006) Dietary glycemic index and liver steatosis. Am J Clin Nutr 84, 136142; quiz 268–139.
40.Le, KA & Bortolotti, M (2008) Role of dietary carbohydrates and macronutrients in the pathogenesis of nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metab Care 11, 477482.
41.Fedirko, V, Lukanova, A, Bamia, C, et al. (2013) Glycemic index, glycemic load, dietary carbohydrate, and dietary fiber intake and risk of liver and biliary tract cancers in Western Europeans. Ann Oncol 24, 543553.
42.George, SM, Mayne, ST, Leitzmann, MF, et al. (2009) Dietary glycemic index, glycemic load, and risk of cancer: a prospective cohort study. Am J Epidemiol 169, 462472.
43.Hu, J, La Vecchia, C, Augustin, LS, et al. (2013) Glycemic index, glycemic load and cancer risk. Ann Oncol 24, 245251.
44.Lagiou, P, Rossi, M, Tzonou, A, et al. (2009) Glycemic load in relation to hepatocellular carcinoma among patients with chronic hepatitis infection. Ann Oncol 20, 17411745.
45.Rossi, M, Lipworth, L, Maso, LD, et al. (2009) Dietary glycemic load and hepatocellular carcinoma with or without chronic hepatitis infection. Ann Oncol 20, 17361740.
46.Vogtmann, E, Li, HL, Shu, XO, et al. (2013) Dietary glycemic load, glycemic index, and carbohydrates on the risk of primary liver cancer among Chinese women and men. Ann Oncol 24, 238244.
47.Kuper, H, Tzonou, A, Lagiou, P, et al. (2000) Diet and hepatocellular carcinoma: a case–control study in Greece. Nutr Cancer 38, 612.
48.Tasevska, N, Jiao, L, Cross, AJ, et al. (2012) Sugars in diet and risk of cancer in the NIH-AARP diet and health study. Int J Cancer 130, 159169.
49.Mozaffarian, RS, Lee, RM, Kennedy, MA, et al. (2013) Identifying whole grain foods: a comparison of different approaches for selecting more healthful whole grain products. Public Health Nutr 16, 22552264.
50.AlEssa, HB, Bhupathiraju, SN, Malik, VS, et al. (2015) Carbohydrate quality and quantity and risk of type 2 diabetes in US women. Am J Clin Nutr 102, 15431553.
51.AlEssa, HB, Cohen, R, Malik, VS, et al. (2018) Carbohydrate quality and quantity and risk of coronary heart disease among US women and men. Am J Clin Nutr 107, 257267.
52.Duarte-Salles, T, Fedirko, V, Stepien, M, et al. (2015) Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort. Int J Cancer 137, 27152728.
53.Freedman, ND, Cross, AJ, McGlynn, KA, et al. (2010) Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohort. J Natl Cancer Inst 102, 13541365.
54.Polesel, J, Talamini, R, Montella, M, et al. (2007) Nutrients intake and the risk of hepatocellular carcinoma in Italy. Eur J Cancer 43, 23812387.
55.Hadziyannis, S, Tabor, E, Kaklamani, E, et al. (1995) A case–control study of hepatitis B and C virus infections in the etiology of hepatocellular carcinoma. Int J Cancer 60, 627631.
56.Koh, WP, Dan, YY, Goh, GB, et al. (2016) Dietary fatty acids and risk of hepatocellular carcinoma in the Singapore Chinese health study. Liver Int 36, 893901.
57.Yang, W, Sui, J, Ma, Y, et al. (2020) High dietary intake of vegetable or polyunsaturated fats is associated with reduced risk of hepatocellular carcinoma. Clin Gastroenterol Hepatol (epublication ahead of print version 9 January 2020).
58.Endres, S, Ghorbani, R, Kelley, VE, et al. (1989) The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 320, 265271.
59.James, MJ, Gibson, RA & Cleland, LG (2000) Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 71, 343S348S.
60.Fauser, JK, Prisciandaro, LD, Cummins, AG, et al. (2011) Fatty acids as potential adjunctive colorectal chemotherapeutic agents. Cancer Biol Therapy 11, 724731.
61.Lim, K, Han, C, Dai, Y, et al. (2009) Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2. Mol Cancer Therapeut 8, 30463055.
62.Capanni, M, Calella, F, Biagini, MR, et al. (2006) Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. Aliment Pharm Ther 23, 11431151.
63.de Castro, GS & Calder, PC (2017) Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids. Clin Nutr 37, 3755.
64.Di Minno, MN, Russolillo, A, Lupoli, R, et al. (2012) Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease. World J Gastroenterol 18, 58395847.
65.Calder, PC (2006) Polyunsaturated fatty acids and inflammation. Prostagl Leukotr Ess Fatty Acids 75, 197202.
66.Monteiro, J, Leslie, M, Moghadasian, MH, et al. (2014) The role of n-6 and n-3 polyunsaturated fatty acids in the manifestation of the metabolic syndrome in cardiovascular disease and non-alcoholic fatty liver disease. Food Funct 5, 426435.
67.Sawada, N, Inoue, M, Iwasaki, M, et al. (2012) Consumption of n-3 fatty acids and fish reduces risk of hepatocellular carcinoma. Gastroenterology 142, 14681475.
68.Song, M & Giovannucci, E (2018) Substitution analysis in nutritional epidemiology: proceed with caution. Eur J Epidemiol 33, 137140.
69.Takami, T, Yamasaki, T, Saeki, I, et al. (2016) Supportive therapies for prevention of hepatocellular carcinoma recurrence and preservation of liver function. World J Gastroenterol 22, 72527263.
70.Sugiyama, K, Yu, L & Nagasue, N (1998) Direct effect of branched-chain amino acids on the growth and metabolism of cultured human hepatocellular carcinoma cells. Nutr Cancer 31, 6268.
71.Miuma, S, Ichikawa, T, Arima, K, et al. (2012) Branched-chain amino acid deficiency stabilizes insulin-induced vascular endothelial growth factor mRNA in hepatocellular carcinoma cells. J Cell Biochem 113, 31133121.
72.Hagiwara, A, Nishiyama, M & Ishizaki, S (2012) Branched-chain amino acids prevent insulin-induced hepatic tumor cell proliferation by inducing apoptosis through mTORC1 and mTORC2-dependent mechanisms. J Cell Physiol 227, 20972105.
73.Ninomiya, S, Shimizu, M, Imai, K, et al. (2011) Possible role of visfatin in hepatoma progression and the effects of branched-chain amino acids on visfatin-induced proliferation in human hepatoma cells. Cancer Prevent Res 4, 20922100.
74.Ichikawa, K, Okabayashi, T, Maeda, H, et al. (2013) Oral supplementation of branched-chain amino acids reduces early recurrence after hepatic resection in patients with hepatocellular carcinoma: a prospective study. Surg Today 43, 720726.
75.Okabayashi, T, Iyoki, M, Sugimoto, T, et al. (2011) Oral supplementation with carbohydrate- and branched-chain amino acid-enriched nutrients improves postoperative quality of life in patients undergoing hepatic resection. Amino Acids 40, 12131220.
76.Kuroda, H, Ushio, A, Miyamoto, Y, et al. (2010) Effects of branched-chain amino acid-enriched nutrient for patients with hepatocellular carcinoma following radiofrequency ablation: a one-year prospective trial. J Gastroenterol Hepatol 25, 15501555.
77.Meng, WC, Leung, KL, Ho, RL, et al. (1999) Prospective randomized control study on the effect of branched-chain amino acids in patients with liver resection for hepatocellular carcinoma. Austr N Z J Surg 69, 811815.
78.Lee, IJ, Seong, J, Bae, JI, et al. (2011) Effect of oral supplementation with branched-chain amino acid (BCAA) during radiotherapy in patients with hepatocellular carcinoma: a double-blind randomized study. Cancer Res Treat 43, 2431.
79.Luo, J, Yang, Y, Liu, J, et al. (2014) Systematic review with meta-analysis: meat consumption and the risk of hepatocellular carcinoma. Aliment Pharmacol Ther 39, 913922.
80.Ma, X, Yang, Y, Li, HL, et al. (2017) Dietary trace element intake and liver cancer risk: results from two population-based cohorts in China. Int J Cancer 140, 10501059.
81.Fang, AP, Chen, PY, Wang, XY, et al. (2019) Serum copper and zinc levels at diagnosis and hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort. Int J Cancer 144, 28232832.
82.Fang, AP, Liu, ZY, Liao, GC, et al. (2019) Serum folate concentrations at diagnosis are associated with hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort study. Br J Nutr 121, 13761388.
83.Zhang, W, Shu, XO, Li, H, et al. (2012) Vitamin intake and liver cancer risk: a report from two cohort studies in China. J Natl Cancer Inst 104, 11731181.
84.Lan, QY, Zhang, YJ, Liao, GC, et al. (2016) The association between dietary vitamin A and carotenes and the risk of primary liver cancer: a case–control study. Nutrients 8, 624.
85.Yuan, JM, Gao, YT, Ong, CN, et al. (2006) Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma. J Natl Cancer Inst 98, 482490.
86.Lai, GY, Weinstein, SJ, Albanes, D, et al. (2014) Association of serum alpha-tocopherol, beta-carotene, and retinol with liver cancer incidence and chronic liver disease mortality. Br J Cancer 111, 21632171.
87.Fang, AP, Long, JA, Zhang, YJ, et al. (2019) Serum bioavailable, rather than total, 25-hydroxyvitamin D levels are associated with hepatocellular carcinoma survival. Hepatology (epublication ahead of print version 2 November 2019).
88.Wolonciej, M, Milewska, E & Roszkowska-Jakimiec, W (2016) Trace elements as an activator of antioxidant enzymes. Postepy Hig Med Dosw 70, 14831498.
89.Puertollano, MA, Puertollano, E, de Cienfuegos, GA, et al. (2011) Dietary antioxidants: immunity and host defense. Curr Top Med Chem 11, 17521766.
90.Ma, J, Giovannucci, E, Pollak, M, et al. (2001) Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men. J Natl Cancer Inst 93, 13301336.
91.Holmes, MD, Pollak, MN, Willett, WC, et al. (2002) Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomarkers Prevent 11, 852861.
92.Hoppe, C, Molgaard, C, Juul, A, et al. (2004) High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys. Eur J Clin Nutr 58, 12111216.
93.Heaney, RP, McCarron, DA, Dawson-Hughes, B, et al. (1999) Dietary changes favorably affect bone remodeling in older adults. J Am Dietetic Assoc 99, 12281233.
94.Hopfner, M, Huether, A, Sutter, AP, et al. (2006) Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells. Biochem Pharmacol 71, 14351448.
95.Duarte-Salles, T, Fedirko, V, Stepien, M, et al. (2014) Dairy products and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 135, 16621672.
96.Yang, W, Sui, J, Ma, Y, et al. (2020) A prospective study of dairy product intake and the risk of hepatocellular carcinoma in U.S. men and women. Int J Cancer 146, 12411249.
97.Fukuda, K, Shibata, A, Hirohata, I, et al. (1993) A hospital-based case–control study on hepatocellular carcinoma in Fukuoka and Saga Prefectures, northern Kyushu, Japan. Jpn J Cancer Res 84, 708714.
98.Talamini, R, Polesel, J, Montella, M, et al. (2006) Food groups and risk of hepatocellular carcinoma: a multicenter case–control study in Italy. Int J Cancer 119, 29162921.
99.La Vecchia, C, Negri, E, Decarli, A, et al. (1988) Risk factors for hepatocellular carcinoma in northern Italy. Int J Cancer 42, 872876.
100.Yu, SZ, Huang, XE, Koide, T, et al. (2002) Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China. Jpn J Cancer Res 93, 12871292.
101.Park, Y, Leitzmann, MF, Subar, AF, et al. (2009) Dairy food, calcium, and risk of cancer in the NIH-AARP Diet and Health Study. Arch Inter Med 169, 391401.
102.Zhang, W, Xiang, YB, Li, HL, et al. (2013) Vegetable-based dietary pattern and liver cancer risk: results from the Shanghai women’s and men’s health studies. Cancer Sci 104, 13531361.
103.Yang, W, Ma, Y, Liu, Y, et al. (2019) Association of intake of whole grains and dietary fiber with risk of hepatocellular carcinoma in US Adults. JAMA Oncol 5, 879886.
104.Kim, Y & Je, Y (2014) Dietary fiber intake and total mortality: a meta-analysis of prospective cohort studies. Am J Epidemiol 180, 565573.
105.Aune, D, Keum, N, Giovannucci, E, et al. (2016) Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose–response meta-analysis of prospective studies. BMJ 353, i2716.
106.Threapleton, DE, Greenwood, DC, Evans, CE, et al. (2013) Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis. BMJ 347, f6879.
107.Yao, B, Fang, H, Xu, W, et al. (2014) Dietary fiber intake and risk of type 2 diabetes: a dose–response analysis of prospective studies. Eur J Epidemiol 29, 7988.
108.Aune, D, Chan, DS, Lau, R, et al. (2011) Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose–response meta-analysis of prospective studies. BMJ 343, d6617.
109.Ben, Q, Sun, Y, Chai, R, et al. (2014) Dietary fiber intake reduces risk for colorectal adenoma: a meta-analysis. Gastroenterology 146, 689699.
110.Murphy, N, Norat, T, Ferrari, P, et al. (2012) Dietary fibre intake and risks of cancers of the colon and rectum in the European Prospective Investigation into Cancer and Nutrition (EPIC). PLOS ONE 7, e39361.
111.Hansen, L, Skeie, G, Landberg, R, et al. (2012) Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort. Int J Cancer 131, 469478.
112.Schatzkin, A, Mouw, T, Park, Y, et al. (2007) Dietary fiber and whole-grain consumption in relation to colorectal cancer in the NIH-AARP Diet and Health Study. Am J Clin Nutr 85, 13531360.
113.DiNicolantonio, JJ, Subramonian, AM & O’Keefe, JH (2017) Added fructose as a principal driver of non-alcoholic fatty liver disease: a public health crisis. Open Heart 4, e000631.
114.Ros, E (2010) Health benefits of nut consumption. Nutrients 2, 652682.
115.Ros, E & Hu, FB (2013) Consumption of plant seeds and cardiovascular health: epidemiological and clinical trial evidence. Circulation 128, 553565.
116.Han, JM, Jo, AN, Lee, SM, et al. (2014) Associations between intakes of individual nutrients or whole food groups and non-alcoholic fatty liver disease among Korean adults. J Gastroenterol Hepatol 29, 12651272.
117.Sui, J, Yang, W, Ma, Y, et al. (2019) A prospective study of nut consumption and risk of primary hepatocellular carcinoma in the U.S. women and men. Cancer Prevent Res 12, 367374.
118.Bouvard, V, Loomis, D, Guyton, KZ, et al. (2015) Carcinogenicity of consumption of red and processed meat. Lancet Oncol 16, 15991600.
119.Huang, RX, Duan, YY & Hu, JA (2015) Fish intake and risk of liver cancer: a meta-analysis. PLOS ONE 10, e0096102.
120.Fedirko, V, Trichopolou, A, Bamia, C, et al. (2013) Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC). Ann Oncol 24, 21662173.
121.Kurozawa, Y, Ogimoto, I, Shibata, A, et al. (2004) Dietary habits and risk of death due to hepatocellular carcinoma in a large scale cohort study in Japan. Univariate analysis of JACC study data. Kurume Med J 51, 141149.
122.Ma, Y, Yang, W, Li, T, et al. (2019) Meat intake and risk of hepatocellular carcinoma in two large US prospective cohorts of women and men. Int J Epidemiol 48, 18631871.
123.Su, SJ, Chow, NH, Kung, ML, et al. (2003) Effects of soy isoflavones on apoptosis induction and G2-M arrest in human hepatoma cells involvement of caspase-3 activation, Bcl-2 and Bcl-XL downregulation, and Cdc2 kinase activity. Nutr Cancer 45, 113123.
124.Sharp, GB, Lagarde, F, Mizuno, T, et al. (2005) Relationship of hepatocellular carcinoma to soya food consumption: a cohort-based, case–control study in Japan. Int J Cancer 115, 290295.
125.Kurahashi, N, Inoue, M, Iwasaki, M, et al. (2009) Isoflavone consumption and subsequent risk of hepatocellular carcinoma in a population-based prospective cohort of Japanese men and women. Int J Cancer 124, 16441649.
126.Lagiou, P, Rossi, M, Lagiou, A, et al. (2008) Flavonoid intake and liver cancer: a case–control study in Greece. Cancer Causes Control 19, 813818.
127.Zamora-Ros, R, Fedirko, V, Trichopoulou, A, et al. (2013) Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European Prospective Investigation into Cancer and Nutrition study. Int J Cancer 133, 24292443.
128.Zhang, W, Wang, J, Gao, J, et al. (2019) Prediagnostic level of dietary and urinary isoflavonoids in relation to risk of liver cancer in Shanghai, China. Cancer Epidemiol Biomarkers Prev 28, 17121719.
129.Illig, T, Gieger, C, Zhai, G, et al. (2009) A genome-wide perspective of genetic variation in human metabolism. Nat Genet 42, 137.
130.Shoaie, S, Ghaffari, P, Kovatcheva-Datchary, P, et al. (2015) Quantifying diet-induced metabolic changes of the human gut microbiome. Cell Metab 22, 320331.
131.Guertin, KA, Moore, SC, Sampson, JN, et al. (2014) Metabolomics in nutritional epidemiology: identifying metabolites associated with diet and quantifying their potential to uncover diet–disease relations in populations. Am J Clin Nutr 100, 208217.
132.Bhupathiraju, SN & Hu, FB (2017) One (small) step towards precision nutrition by use of metabolomics. Lancet Diabetes Endocrinol 5, 154155.
133.Guasch-Ferré, M, Bhupathiraju, SN & Hu, FB (2018) Use of metabolomics in improving assessment of dietary intake. Clin Chem 64, 8298.
134.Yang, CS, Wang, X, Lu, G, et al. (2009) Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 9, 429439.
135.Fon Sing, M, Yang, WS, Gao, S, et al. (2011) Epidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis. Eur J Cancer Prev 20, 157165.
136.Bamia, C, Lagiou, P, Jenab, M, et al. (2015) Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: multicentre, prospective cohort study. Int J Cancer 136, 18991908.
137.Huang, YQ, Lu, X, Min, H, et al. (2016) Green tea and liver cancer risk: a meta-analysis of prospective cohort studies in Asian populations. Nutrition 32, 38.
138.Tamura, T, Wada, K, Konishi, K, et al. (2018) Coffee, green tea, and caffeine intake and liver cancer risk: a prospective cohort study. Nutr Cancer 70, 12101216.
139.Butler, LM, Huang, JY, Wang, R, et al. (2015) Urinary biomarkers of catechins and risk of hepatocellular carcinoma in the Shanghai Cohort Study. Am J Epidemiol 181, 397405.
140.Bravi, F, Bosetti, C, Tavani, A, et al. (2013) Coffee reduces risk for hepatocellular carcinoma: an updated meta-analysis. Clin Gastroenterol Hepatol 11, 14131421.
141.Sang, LX, Chang, B, Li, XH, et al. (2013) Consumption of coffee associated with reduced risk of liver cancer: a meta-analysis. BMC Gastroenterol 13, 34.
142.Bai, K, Cai, Q, Jiang, Y, et al. (2016) Coffee consumption and risk of hepatocellular carcinoma: a meta-analysis of eleven epidemiological studies. Oncol Targets Ther 9, 43694375.
143.Yu, C, Cao, Q, Chen, P, et al. (2016) An updated dose–response meta-analysis of coffee consumption and liver cancer risk. Sci Rep 6, 37488.
144.Bravi, F, Tavani, A, Bosetti, C, et al. (2017) Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies. Eur J Cancer Prev 26, 368377.
145.Godos, J, Micek, A, Marranzano, M, et al. (2017) Coffee consumption and risk of biliary tract cancers and liver cancer: a dose–response meta-analysis of prospective cohort studies. Nutrients 9, E950.
146.Kennedy, OJ, Roderick, P, Buchanan, R, et al. (2017) Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose–response meta-analysis. BMJ Open 7, e013739.
147.Tamura, T, Hishida, A & Wakai, K (2019) Coffee consumption and liver cancer risk in Japan: a meta-analysis of six prospective cohort studies. Nagoya J Med Sci 81, 143150.
148.Jang, ES, Jeong, SH, Lee, SH, et al. (2013) The effect of coffee consumption on the development of hepatocellular carcinoma in hepatitis B virus endemic area. Liver Int 33, 10921099.
149.Lai, GY, Weinstein, SJ, Albanes, D, et al. (2013) The association of coffee intake with liver cancer incidence and chronic liver disease mortality in male smokers. Br J Cancer 109, 13441351.
150.Aleksandrova, K, Bamia, C, Drogan, D, et al. (2015) The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 102, 14981508.
151.Petrick, JL, Freedman, ND, Graubard, BI, et al. (2015) Coffee consumption and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma by sex: the liver cancer pooling project. Cancer Epidemiol Biomarkers Prev 24, 13981406.
152.Setiawan, VW, Wilkens, LR, Lu, SC, et al. (2015) Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort. Gastroenterology 148, 118125; quiz e115.
153.Loftfield, E, Rothwell, JA, Sinha, R, et al. (2019) Prospective investigation of serum metabolites, coffee drinking, liver cancer incidence, and liver disease mortality. J Natl Cancer Inst 112, 286294.
154.Loomba, R, Yang, HI, Su, J, et al. (2013) Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. Am J Epidemiol 177, 333342.
155.Petrick, JL, Campbell, PT, Koshiol, J, et al. (2018) Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: the liver cancer pooling project. Br J Cancer 118, 10051012.
156.Turati, F, Galeone, C, Rota, M, et al. (2014) Alcohol and liver cancer: a systematic review and meta-analysis of prospective studies. Ann Oncol 25, 15261535.
157.Chuang, SC, Lee, YC, Wu, GJ, et al. (2015) Alcohol consumption and liver cancer risk: a meta-analysis. Cancer Causes Control 26, 12051231.
158.Schrieks, IC, Heil, AL, Hendriks, HF, et al. (2015) The effect of alcohol consumption on insulin sensitivity and glycemic status: a systematic review and meta-analysis of intervention studies. Diabetes Care 38, 723732.
159.Tapsell, LC, Neale, EP, Satija, A, et al. (2016) Foods, Nutrients, and Dietary Patterns: interconnectionsd and implications for dietary guidelines. Adv Nutr 7, 445454.
160.Chen, PY, Fang, AP, Wang, XY, et al. (2018) Adherence to the Chinese or American dietary guidelines is associated with a lower risk of primary liver cancer in China: a case–control study. Nutrients 10.
161.Li, WQ, Park, Y, McGlynn, KA, et al. (2014) Index-based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study. Hepatology 60, 588597.
162.Ma, Y, Yang, W, Simon, TG, et al. (2018) Dietary patterns and risk of hepatocellular carcinoma among U.S. men and women. Hepatology 70, 577586.
163.National Cancer Institute (2018) Applied Research: Cancer Control and Population Sciences. Dietary patterns methods project. https://epi.grants.cancer.gov/dietary-patterns/ (accessed September 2018).
164.Tabung, FK, Smith-Warner, SA, Chavarro, JE, et al. (2016) Development and validation of an empirical dietary inflammatory index. J Nutr 146, 15601570.
165.Tabung, FK, Wang, W, Fung, TT, et al. (2016) Development and validation of empirical indices to assess the insulinaemic potential of diet and lifestyle. Br J Nutr 116, 17871798.

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Diet and liver cancer risk: a narrative review of epidemiological evidence

  • Wan-Shui Yang (a1), Xu-Fen Zeng (a1), Zhi-Ning Liu (a2), Qi-Hong Zhao (a1), Yu-Ting Tan (a3), Jing Gao (a3), Hong-Lan Li (a3) and Yong-Bing Xiang (a3)...

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