Skip to main content Accessibility help
×
Home

Deposition of fat in the body of the rat during rehabilitation after early undernutrition

  • Patricia M. Harris (a1) and Elsie M. Widdowson (a1)

Abstract

1. Male and female rats aged 3 weeks were divided into two groups. One group of each sex was allowed unlimited access to the stock diet, the other group was given the stock diet in restricted amounts for 10 weeks so that the males gained only 19 g and the females 21 g in comparison with 176 g and 116 g for the well-nourished males and females respectively. The undernourished animals were then rehabilitated by being allowed the stock diet ad lib.

2. Five animals of each sex were killed at various stages of the experiment, their bodies analysed for fat and nitrogen, and the size and number of fat cells determined in specific fat depots.

3. The undernourished rats failed to make a complete recovery and were significantly smaller than the controls of the same sex at 172 d of age when the experiment terminated.

4. The previously undernourished rats deposited significantly more fat in their bodies during rehabilitation than the control animals in the same number of days and over the same gain in body-weight.

5. There were no significant differences in the number of cells containing fat at the abdominal fat site between the undernourished and rehabilitated animals and the controls at any stage, nor were there any significant differences in apparent fat cell numbers between the control and rehabilitated animals at any of the other sites studied when the experiment ended at 172 d.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Deposition of fat in the body of the rat during rehabilitation after early undernutrition
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Deposition of fat in the body of the rat during rehabilitation after early undernutrition
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Deposition of fat in the body of the rat during rehabilitation after early undernutrition
      Available formats
      ×

Copyright

References

Hide All
Allden, W. G. (1970). Nutr. Abstr. Rev. 40, 1167.
Ashworth, A. (1969). Br. J. Nutr. 23, 835.
Brook, C. G. D. (1972). Lancet ii, 624.
Dauncey, M. J. & Gairdner, D. (1975). Archs Dis. Childh. 50, 286.
Elsley, F. W. H., McDonald, I. & Fowler, V. R. (1964). Anim. Prod. 6, 141.
Greenwood, M. R. C. & Hirsch, J. (1974). J. Lipid Res. 15, 474.
Hirsch, J. & Han, P. (1969). J. Lipid Res. 10, 77.
Hirsch, J. & Knittle, J. L. (1970). Fedn Proc. Fedn Am. Socs exp. biol. 29, 1516.
Lister, D. & McCance, R. A. (1967). Br. J. Nutr. 21, 787.
McMeekan, C. P. (1940). J. agric. Sci., Camb. 30, 511.
Meyer, J. H. & Clawson, W. J. (1964). J. Anim. Sci. 23, 214.
Munro, H. N. & Fleck, A. (1969). In Mammalian Protein Metabolism, Vol. 3, p. 423 [Munro, H. N. editor]. New York and London: Academic Press.
Ridgman, W. J. (1975). Experimentation in Biology. London: Blackie.
Southgate, D. A. T. (1971). J. Sci. Fd Agric. 22, 590.
Widdowson, E. M. (1974). Adv. exp. Med. Biol. 49, 165.
Widdowson, E. M. (1977). Proc. Nutr. Soc. (In the press.)
Widdowson, E. M., Mavor, W. O. & McCance, R. A. (1964). J. Endocr. 29, 119.
Widdowson, E. M. & Shaw, W. T. (1973). Lancet ii, 905.

Deposition of fat in the body of the rat during rehabilitation after early undernutrition

  • Patricia M. Harris (a1) and Elsie M. Widdowson (a1)

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed