Hostname: page-component-84b7d79bbc-g7rbq Total loading time: 0 Render date: 2024-07-28T16:40:34.084Z Has data issue: false hasContentIssue false
  • English
  • Français

Comparative biological availability of manganese from extrinsically labelled milk diets using sucking rats as a model

Published online by Cambridge University Press:  09 March 2007

M. Hassan Raghib. ,
Chan Wai-Yee  and
M. Owen Rennert
M. Hassan Raghib.
Affiliation:
Department of Pediatrics and Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
Chan Wai-Yee
Affiliation:
Department of Pediatrics and Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
M. Owen Rennert
Affiliation:
Department of Pediatrics and Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Very little is known about the biological availability of manganese from human milk and other infant milk diets. To determine the relative Mn availability, and to examine whether the age and the duration of previous fasting affect Mn absorption, sucking rats were given human milk, bovine milk and infant formula (regular Similac; Ross Laboratories, Columbus, OH) extrinsically labelled with 54Mn.

2. Milk diets were given by gastric intubation and the radioactivity of the carcass, liver and digestive tract was measured 3 h after feeding.

3. The concentration of endogenous Mn was lowest in human milk (7–10 μg/l) and highest in rat milk (140–165 μg/l). Increasing the non-radioactive total Mn concentrations of either human milk or bovine milk up to 150 μg/l did not affect the absorption of 54Mn by 10-d-old rats.

4. No significant (P> 0.05) difference in 54Mn absorption was found among the three milk diets (human milk, bovine milk, infant formula) in 8- to 11-d-old rats. However, significantly more (P< 0.05) 54Mn was absorbed from human milk and infant formula than from bovine milk when 13-d-old rats were used.

5. 54Mn radioactivity detected in carcasses of 8-, 9-, 10- and 11-d-old rats ranged from 25 to 27% of the dose from various milk diets. The activities of 54Mn in the carcasses of 13-d-old rats were 15, 11, and 16% of the dose from human milk, bovine milk and infant formula respectively.

6. The trend of 54Mn incorporation into liver was similar to that of the carcass and over 60% of the absorbed 54Mn was incorporated into the liver regardless of the type of milk used.

7. Absorption of 54Mn from extrinsically labelled rat milk using 9- or 10-d-old sucking rats was similar to its absorption from infant formula.

8. The absorption of 54Mn from the three milk diets decreased with age of the neonatal rats and 54Mn absorption from human milk, bovine milk, infant formula as well as rat milk was affected similarly by duration of previous fasting.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 55 , Issue 1 , January 1986 , pp. 49 - 58
Copyright
Copyright © The Nutrition Society 1986

References

REFERENCES

Alexander, A. R., Whanger, P. D. & Miller, L. T. (1983). Journal of Nutrition 113, 196–204.CrossRefGoogle Scholar
Barness, L. A. (1981). In Textbook of Pediatric Nutrition, pp. 21–28 [Suskind, R. M., editor]. New York: Raven Press.Google Scholar
Black, J. R., Ammerman, C. B., Henry, P. R. & Miles, R. D. (1984). Nutrition Reports International 29, 807–814.Google Scholar
Chan, W. Y., Bates, J. M. Jr. & Rennert, O. M. (1982). Journal of Nutrition 112, 642–651.CrossRefGoogle Scholar
Chan, W. Y., Bates, J. M. Jr., Rennert, O. M., Mahmood, A. & Torres-Pinedo, R. (1984). Life Sciences 35, 2415–2419.CrossRefGoogle Scholar
Committee on Nutrition (1979). Pediatric Nutrition Handbook, p. 92. Evanston, IL: American Academy of Pediatricians.Google Scholar
Cotzias, G. C. & Papavasiliou, P. S. (1964). Nature 201, 828–829.CrossRefGoogle Scholar
Duncan, J. R & Hurley, L. S. (1978). American Journal of Physiology 235, E556–E559.Google Scholar
Fairweather-Tait, S. J. & Wright, A. J. (1984). British Journal of Nutrition 51, 185–191.CrossRefGoogle Scholar
Feller, W. F. & Boretos, J. (1967). Journal of National Cancer Institute 38, 11–15.Google Scholar
Forbes, R. M. & Erdman, J. W. Jr. (1983). Annual Review of Nutrition 3, 213–231.CrossRefGoogle Scholar
Garcia-Aranda, J. A., Wapnir, R. A. & Lifshitz, F. (1983). Journal of Nutrition 113, 2601–2607.CrossRefGoogle Scholar
Gruden, N. (1976). Nutrition Reports International 14, 515–520.Google Scholar
Hoffman, F. A, Sawatzki, G., Schmitt, H. & Kubanet, B. (1982). Laboratory Animal Science 32, 387–388.Google Scholar
Hurley, L. S. (1982). In Clinical, Biochemical and Nutritional Aspects of Trace Elements, pp. 369–378 [Prasad, A. S., editor]. New York: Alan R. Liss Inc.Google Scholar
Jackson, M. J., Jones, D. A. & Edwards, R. H. T. (1981). British Journal of Nutrition 46, 15–27.CrossRefGoogle Scholar
Kostial, K., Robar, I., Blanusa, M. & Landeka, M. (1979). Proceedings of the Nutrition Society 38, 251–256.CrossRefGoogle Scholar
Kostial, K., Robar, I., Blanusa, M. & Simonovic, I. (1980). Environmental Research 22, 40–45.CrossRefGoogle Scholar
McMillan, J. A., Oski, F. A, Lourie, G., Tomarelli, R. M. & Landaw, S. A. (1977). Pediatrics 60, 896–900.CrossRefGoogle Scholar
Miller, J. & McNeal, L. S. (1983). Journal of Nutrition 113, 115–123.CrossRefGoogle Scholar
Mraz, F. R. & Eisele, G. R. (1977). Pediatric Research 69, 591–593.Google Scholar
Nagasawa, H. (1979). Laboratory Animal Science 29, 633–635.Google Scholar
Papavasiliou, P. S., Miller, S. T. & Cotzias, G. C. (1966). American Journal of Physiology 211, 211–216.CrossRefGoogle Scholar
Saarinen, U. M., Siimes, M. A. & Dallman, P. R. (1977). Journal of Pediatrics 41, 36–39.CrossRefGoogle Scholar
Sandström, B., Cederblad, A. & Lönnerdal, B. (1983 a). American Journal of Diseases of Children 131, 726–729.Google Scholar
Sandström, B., Keen, C. L. & Lönnerdal, B. (1983 b). American Journal of Clinical Nutrition 38, 420&428.CrossRefGoogle Scholar
Sasser, L. B. & Jarboe, G. E. (1977). Toxicology and Applied Pharmacology 41, 423–431.CrossRefGoogle Scholar
Shah, B. G. (1981). Progress in Clinical and Biological Research 11, 199–208.Google Scholar
Shaw, J. C. L. (1980). American Journal of Diseases of Children 134, 74–87.CrossRefGoogle Scholar