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Changes in serum cholinesterase (EC 3 1 * 1 * 8) activity in rats consuming a high-fat diet*

Published online by Cambridge University Press:  09 March 2007

Jesus Osada
Affiliation:
Departamento de Bioquimica y Biologia Molecular, Facultad de Veterinariu, Miguel Servet, 177, 50.013 Zaragoza, Spain
Hortensia Aylagas
Affiliation:
Instituto de Bioquimica, Centro mixto (CSIC- UCM), Facultad de Farmacia, Ciudad Universitaria, 28.040 Madrid,Spain
Gonzalo Cao
Affiliation:
Servicio de Analisis Clinicos, Hospital de la Seguridad Social, LPrida, Spain
Maria Jesus MIRo−Obradors
Affiliation:
Instituto de Bioquimica, Centro mixto (CSIC- UCM), Facultad de Farmacia, Ciudad Universitaria, 28.040 Madrid,Spain
Evangelina Palacios−Alaiz
Affiliation:
Departamento de Bioquimica y Biologia Molecular, Facultad de Veterinariu, Miguel Servet, 177, 50.013 Zaragoza, Spain
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Abstract

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Adult male rats were fed on a control diet containing (g/kg) carbohydrate 600, lipid 35 and protein 190, or on a high-fat diet containing carbohydrate 360, lipid 420 and protein 120. After 30 d, the high-fat diet provoked a decrease in serum cholinesterase (EC 3.1.1.8) activity which was reversed by feeding rats on the control diet. The observed decrease after 90 d on the high-fat diet was not seen if a simultaneous daily intraperitoneal injection of a lipotrophic agent containing (mg/kg) S-adenosyl-l-methionine 3, coenzyme A 0.1, UDP-glucose 30 and CDP-choline 1.5 was given to rats on the high-fat diet. The findings are discussed in relation to the apparent susceptibility of serum cholinesterase to dietary components and its possible role in lipid metabolism.

Type
Lipids
Copyright
Copyright © The Nutrition Society 1989

References

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