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Changes in serum cholinesterase (EC 3 1 * 1 * 8) activity in rats consuming a high-fat diet*

Published online by Cambridge University Press:  09 March 2007

Jesus Osada ,
Hortensia Aylagas ,
Gonzalo Cao ,
Maria Jesus MIRo−Obradors  and
Evangelina Palacios−Alaiz
Jesus Osada
Affiliation:
Departamento de Bioquimica y Biologia Molecular, Facultad de Veterinariu, Miguel Servet, 177, 50.013 Zaragoza, Spain
Hortensia Aylagas
Affiliation:
Instituto de Bioquimica, Centro mixto (CSIC- UCM), Facultad de Farmacia, Ciudad Universitaria, 28.040 Madrid,Spain
Gonzalo Cao
Affiliation:
Servicio de Analisis Clinicos, Hospital de la Seguridad Social, LPrida, Spain
Maria Jesus MIRo−Obradors
Affiliation:
Instituto de Bioquimica, Centro mixto (CSIC- UCM), Facultad de Farmacia, Ciudad Universitaria, 28.040 Madrid,Spain
Evangelina Palacios−Alaiz
Affiliation:
Departamento de Bioquimica y Biologia Molecular, Facultad de Veterinariu, Miguel Servet, 177, 50.013 Zaragoza, Spain
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Abstract

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Adult male rats were fed on a control diet containing (g/kg) carbohydrate 600, lipid 35 and protein 190, or on a high-fat diet containing carbohydrate 360, lipid 420 and protein 120. After 30 d, the high-fat diet provoked a decrease in serum cholinesterase (EC 3.1.1.8) activity which was reversed by feeding rats on the control diet. The observed decrease after 90 d on the high-fat diet was not seen if a simultaneous daily intraperitoneal injection of a lipotrophic agent containing (mg/kg) S-adenosyl-l-methionine 3, coenzyme A 0.1, UDP-glucose 30 and CDP-choline 1.5 was given to rats on the high-fat diet. The findings are discussed in relation to the apparent susceptibility of serum cholinesterase to dietary components and its possible role in lipid metabolism.

Keywords

Cholinesterase activityDietary fatRat
Type
Lipids
Information
British Journal of Nutrition , Volume 62 , Issue 2 , September 1989 , pp. 343 - 348
Copyright
Copyright © The Nutrition Society 1989

References

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