The WHI programme is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services through contracts N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32 and 44221 and is registered with Clinicaltrials.gov (record no. NCT00000611). This manuscript was prepared in collaboration with investigators of the WHI, and has been reviewed and/or approved by the WHI. The short list of WHI investigators can be found at https://cleo.whi.org/researchers/SitePages/Write%20a%20Paper.aspx. Dr J. M. B. was supported by career development award R00AG035002 sponsored by the National Institute of Aging. Dr L. S. P. is supported in part by FDA award RO1FD003527, Veterans Health Administration (VA) awards HSR&D IIR 07-138 and I01-CX001025, NIH awards R21DK099716, DK066204, U01 DK091958, U01 DK098246 and a Cystic Fibrosis Foundation award PHILLI12A0. The sponsors had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; and preparation, review or approval of the manuscript.
The authors’ responsibilities were as follows: A. Z. L., C. A. T., L. T., R. L. P. and J. M. B. designed the research; A. Z. L., C. A. T., L. T., R. L. P. and J. M. B. conducted the research; J. C. L. analysed the data; M. I., A. Z. L., C. A. T., L. T., Q. Q., L. Q., R. M. C.-D., L. S. P., R. L. P. and J. M. B. wrote the manuscript; and M. I. and J. M. B. had primary responsibility for the final content.
L. S. P. declares that there is no duality of interest associated with this manuscript. With regard to potential conflicts of interest, within the past several years, L. S. P. has served on Scientific Advisory Boards for Boehringer Ingelheim, Janssen and the Profil Institute for Clinical Research, and has or had research support from Merck, Amylin, Eli Lilly, Novo Nordisk, Sanofi, PhaseBio, Roche, Abbvie, Vascular Pharmaceuticals, Janssen, Glaxo SmithKline and the Cystic Fibrosis Foundation. In the past, he was a speaker for Novartis and Merck, but not for the last 5 years. This work is not intended to reflect the official opinion of the VA or the US Government; TBD for others. M. I., A. Z. L., C. A. T., L. T., J. C. L., Q. Q., L. Q., R. M. C.-D., R. L. P. and J. M. B. had no potential conflicts of interest to declare.
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