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Biochemical markers of nutritional status and childhood malaria severity in Cameroon

  • Joël Bertrand Pankoui Mfonkeu (a1), Inocent Gouado (a1), Honoré Fotso Kuaté (a2), Odile Zambou (a3), Valéry Combes (a4), Georges Emile Raymond Grau (a4) and Paul Henri Amvam Zollo (a1)...

Abstract

To investigate the part played by undernutrition in malaria severity, some biomarkers of nutritional status were assessed in children with severe malarial anaemia (MA) and cerebral malaria (CM) in comparison with healthy children or those with uncomplicated malaria. Undernutrition was assessed using the weight-for-age Z score (WAZ). Retinol was determined by HPLC; lipid profile, Ca, Mg and albumin were determined by spectrophotometry. Severe and moderate undernutritions were more prevalent in children with MA and those with the combined symptoms of CM and MA, but not in those with CM alone. Some perturbations were noticed in the lipid profile, but most of the values remained within the normal ranges. The risk of vitamin A deficiency, as assessed by plasma retinol concentration, was noteworthy in children with severe malaria: 0·48 × 10− 6 and 0·50 × 10− 6 mol/l, respectively, in children with MA and CM (reference value: >0·7 × 10− 6 mol/l). A significant difference was obtained for retinol values after an ANOVA of all the groups (P = 0·0029), with the value in the MA group being significantly low than that in the control group (P < 0·05); likewise, a significant difference was obtained after comparison of all the groups for Mg and albumin (P = 0·0064 and 0·0082, respectively). Despite their low number (n 6), fatal cases of CM had a normal mean WAZ on admission, but low values of retinol, albumin and HDL:LDL ratio. Despite these associations, undernutrition itself did not appear to be a primary factor associated with fatal outcome.

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Corresponding author

*Corresponding author: Professor Inocent Gouado, email gouadoi@yahoo.fr

References

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1 Snow, RW, Guerra, CA, Noor, AM, et al. (2005) The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 434, 214217.
2 Idro, R, Jenkins, NE & Newton, CRJC (2005) Pathogenesis, clinical features, and neurological outcome of cerebral malaria. Lancet Neurol 4, 827840.
3 Biemba, G, Dolmans, D, Thuma, PE, et al. (2000) Severe anaemia in Zambian children with Plasmodium falciparum malaria. Trop Med Int Health 5, 916.
4 Walker, SP, Wachs, TD, Gardner, JM, et al. (2007) Child development: risk factors for adverse outcomes in developing countries. Lancet 369, 145157.
5 Field, CJ, Johnson, IR & Schley, PD (2002) Nutrients and their role in host resistance to infection. J Leukoc Biol 71, 1632.
6 Gouado, I, Lehman, LG, Mbouyap, Y, et al. (2007) Influence of malaria on the serum levels of vitamin A, zinc and calcium of children in Douala, Cameroon. Afr J Biotechnol 6, 871876.
7 Akpotuzor, JO, Udoh, AE & Etukudo, MH (2007) Total antioxidant status, vitamin A, C and carotene levels of children with P. falciparum infection in University of Calabar Teaching Hospital (UCTH), Calabar. Pak J Nutr 6, 485489.
8 Cooper, R, Labadarias, D & Louw, ME (2002) Serum vitamin A and E concentrations in acute falciparum malaria; modulators or markers of severity. Am J Clin Nutr 53, 8496.
9 Thurnham, DI (1996) Antioxidants and proxidants in malnourished populations. Proc Nutr Soc 49, 173185.
10 Maitland, K, Pamba, A, Fegan, G, et al. (2005) Perturbations in electrolytes levels in Kenyan children with severe malaria complicated by acidosis. Clin Infect Dis 40, 916.
11 Mitamura, T, Hanad, K, Ko-Mitamura, P, et al. (2000) Serum factors governing intraerythocytic development and cell cycle progression of Plasmodium falciparum. Parasitol Int 49, 219229.
12 Nilsson-Ehle, I & Nilsson-Ehle, P (1990) Changes in plasma lipoproteins in acute malaria. J Int Med 227, 151155.
13 Davis, TME, Sturm, M, Zhang, YR, et al. (1993) Platelet-activating factor and lipid metabolism in acute malaria. J Infect 26, 279285.
14 Brotons, C, Ribera, A, Perich, RM, et al. (1997) Worldwide distribution of blood lipids and lipoproteins in childhood and adolescence: a review study. Atherosclerosis 139, 19.
15 El-Tahir, AE, Malhotra, P & Chauhan, VS (2003) Uptake of proteins and degradation of human serum albumin by Plasmodium falciparum – infected human erythrocytes. Malaria J 2, 18.
16 Mohanty, S, Mishra, SK, Das, BS, et al. (1992) Altered plasma lipid pattern in patients with P. falciparum malaria. Ann Trop Med Parasitol 86, 601606.
17 Faucher, JF, Ngou-Milama, E, Missinou, MA, et al. (2002) The impact of malaria on common lipid parameters. Parasitol Res 88, 10401043.
18 Bentz, MH & Magnette, J (1998) Hypocholesterolemia in the acute phase of inflammation during sepsis. Rev Med Int 19, 168172.
19 Bansal, D, Bhatti, HS & Sehgal, R (2005) Role of cholesterol in parasitic diseases. Lipids Health Dis 4, 10.
20 WHO (2000) Severe falciparum malaria. Trans R Soc Trop Med Hyg 94, 190.
21 Pankoui, MJB, Gouado, I, Fotso, KH, et al. (2008) Clinical presentation, haematological indices and management of children with severe and uncomplicated malaria in Douala, Cameroon. Pak J Biol Sci 11, 24012406.
22 Molyneux, ME, Taylor, TE, Wirima, JJ, et al. (1989) Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Clin Pathol 3, 441459.
23 Jeremiah, ZA & Uko, EK (2007) Comparative analysis of malaria parasite density using actual and assumed white blood cell counts. Ann Trop Paediatr 27, 7579.
24 Caufield, LE, Richard, SA & Black, RE (2004) Undernutrition as an underlying cause of malaria morbidity and mortality in children less than five years old. Am J Trop Med Hyg 71, 5563.
25 Dogan, Y, Erkan, T, Yalvac, S, et al. (2005) Nutritional status of patients hospitalized in paediatric clinic. Turk J Gastroenterol 16, 212216.
26 Bieri, J, Teresa, G, Tolliver, BS, et al. (1979) Simultaneous determination of tocopherol and retinol in plasma or red cells by high pressure liquid chromatography. Am J Clin Nutr 3, 21432149.
27 Johnson, R, McNutt, P, MacMahon, S, et al. (1997) Use of the Friedewald formula to estimate LDL-cholesterol in patients with chronic renal failure on dialysis. Clin Chem 43, 21832184.
28 Schellenberg, D, Schellenberg, JR, Mushi, A, et al. (2003) The silent burden of anaemia in Tanzanian children: a community-based study. Bull World Health Organ 81, 581590.
29 Schaible, UE & Kaufmann, SHE (2007) Malnutrition and infection: complex mechanisms and global impacts. PLoS Med 4, 806810.
30 Reibnegger, G, Fuchs, D & Hausen, A (1987) The dependence of cell-mediated immune activation in malaria on age and endemicity. Trans R Soc Trop Med Hyg 81, 729733.
31 Stephensen, CB (1999) Burden of infection on growth failure. J Nutr 129, 534S538S.
32 Shankar, AH (2000) Nutritional modulation of malaria morbidity and mortality. J Inf Dis 182, S37S53.
33 Djoumessi, S (1989) Serum lipids and lipoproteins during malaria infection. Pathol Biol 37, 909911.
34 Jacobs, DR Jr, Hebert, B, Schreiner, PJ, et al. (1997) Reduced cholesterol is associated with recent minor illness: the CARDIA Study. Coronary Artery Risk Development in Young Adults. Am J Epidemiol 146, 558564.
35 Mohanty, S, Mishra, SK, Das, BS, et al. (1992) Altered plasma lipid pattern in patients with P. falciparum malaria. Ann Trop Med Parasitol 86, 601606.
36 Reibnegger, G, Fuchs, D & Hausen, A (1987) The dependence of cell-mediated immune activation in malaria on age and endemicity. Trans R Soc Trop Med Hyg 81, 729733.
37 Filteau, SM (1999) Vitamin A and the acute-phase response. Nutrition 15, 326328.
38 Goselle, ON, Onwuliri, COE & Onwuliri, VA (2007) Malaria and the effect of malaria parasitaemia on albumin level among HIV/AIDS patients in Jos, Nigeria. J Med Sci 7, 11871191.
39 Butler, SJ, Payne, RB, Gunn, IR, et al. (1984) Correlation between serum ionised calcium and serum albumin concentrations in two hospital populations. Br Med J 289, 948950.
40 Payne, RB, Little, AJ, Williams, RB, et al. (1973) Interpretation of serum calcium in patients with abnormal serum protein. Br Med J 4, 643646.
41 Ogunkolo, OF, Amballi, AA, Adenaike, FA, et al. (2006) Derivation of a formula for adjusting the total serum calcium in Nigeria environment. Afr J Biotechnol 5, 12501253.
42 Garcia, CR (1999) Calcium homeostasis and signalling in the blood-stage malaria parasite. Parasitol Today 15, 488491.
43 Gazarini, M, Thomas, A, Pozzan, T, et al. (2003) Calcium signalling in a low calcium environment: how the intracellular malaria parasite solves the problem. J Cell Biol 161, 103110.

Keywords

Biochemical markers of nutritional status and childhood malaria severity in Cameroon

  • Joël Bertrand Pankoui Mfonkeu (a1), Inocent Gouado (a1), Honoré Fotso Kuaté (a2), Odile Zambou (a3), Valéry Combes (a4), Georges Emile Raymond Grau (a4) and Paul Henri Amvam Zollo (a1)...

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